Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases

  • Authors: Meira Neudorfer, Michael Waisbourd, Irene Anteby, Alon Liran, Dafna Goldenberg, Adiel Barak, Ada Kessler
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  • Published online on: Saturday, January 1, 2011
  • Pages: 91-96
  • DOI: 10.3892/or_00001046

Abstract

The objective of this study was to characterize and differentiate vascular patterns of choroidal melanomas and choroidal metastases by color flow mapping (CFM). We conducted a retrospective chart study on CFM findings in 18 patients with choroidal melanomas and 10 patients with choroidal metastases. We evaluated the possibilities of applying CFM to identify hypo- versus hyper-vascularity within the tumor, a central ‘dominant vessel’, and Doppler signals in the tumor's center and/or periphery. CFM demonstrated hypervascular patterns in 33% melanomas and 100% metastases (p<0.0001). CFM identified a central dominant vessel in 94% melanomas and 0/10 metastases (p<0.0001). Vascularity occupied the center of 11/18 melanomas and 0/10 metastases (p<0.0001), the periphery of 2/18 melanomas and 9/10 metastases (p<0.0001), and equally occupied the tumor's center and periphery of 5/18 melanomas and 1/10 metastases (p<0.0001). Based on our findings, we conclude that CFM was capable of non-invasively demonstrating different and distinct vascular patterns in malignant choroidal melanomas and choroidal metastases.
Journal Cover

January 2011
Volume 25 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
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APA
Neudorfer, M., Waisbourd, M., Anteby, I., Liran, A., Goldenberg, D., Barak, A., & Kessler, A. (2011). Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases . Oncology Reports, 25(1), 91-96.
MLA
Neudorfer, Waisbourd, Anteby, Liran, Goldenberg, Barak, and Ada Kessler. "Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases ." Oncology Reports Oncology Reports 25.1 (2011): 91-96.
Chicago
Neudorfer, Waisbourd, Anteby, Liran, Goldenberg, Barak, and Ada Kessler. "Color flow mapping: a non-invasive tool for characterizing and differentiating between uveal melanomas and choroidal metastases ." Oncology Reports Oncology Reports 25 no. 1 (2011): 91-96.