Human papillomavirus and non-muscle invasive urothelial bladder cancer: Potential relationship from a pilot study

  • Authors:
    • Tommaso Cai
    • Sandra Mazzoli
    • Francesca Meacci
    • Gabriella Nesi
    • Pierangelo Geppetti
    • Gianni Malossini
    • Riccardo Bartoletti
  • View Affiliations

  • Published online on: December 8, 2010     https://doi.org/10.3892/or.2010.1083
  • Pages: 485-489
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Abstract

The relationship between urothelial bladder cancer and high-risk human papillomaviruses (HR-HPV) is still a poorly understood entity, even if some studies have supposed a probably correlation. The aim of the present study was to assess the potential relationship between the presence of HR-HPV and non-muscle invasive urothelial bladder cancers (NMIBC). One hundred and thirty-seven subjects (78 patients affected by NMIBC and 59 controls) were recruited in this prospective study. HR-HPV DNA was evaluated both in urine and tumour tissues. Data from patients were compared with data from controls. The relationship between patients and controls, in terms of HR-HPV presence was performed. The relationship between all pathological data and HR-HPV presence in patient group was carried out. HR-HPV DNA in tissue was found in 27 of 78 (34.6%) tumour samples and in 6 of 59 (10.1%) specimens from TUR-P, with a statistically significant difference (p=0.0009; dF=1; χ2=10.98). HR-HPV DNA in urine was found in 36 of 78 (46.1%) samples obtained from patients, whereas in only 8 of 59 (13.5%) samples from controls (p<0.0001: dF=1; χ2=16.37). A statistical significant difference in terms of HR-HPV frequency between high-grade and low-grade urothelial bladder cancer, was found (p=0.032; RR=0.52 - 95% CI 0.27-0.93; OR=0.34 - 95% CI 0.13-0.90). In conclusion, this study highlights the correlation between urothelial bladder cancer and high-risk type HPV infection, suggesting the potential etiopathogenetic role of HR-HPV in urothelial bladder cancer development.

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February 2011
Volume 25 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cai T, Mazzoli S, Meacci F, Nesi G, Geppetti P, Malossini G and Bartoletti R: Human papillomavirus and non-muscle invasive urothelial bladder cancer: Potential relationship from a pilot study. Oncol Rep 25: 485-489, 2011.
APA
Cai, T., Mazzoli, S., Meacci, F., Nesi, G., Geppetti, P., Malossini, G., & Bartoletti, R. (2011). Human papillomavirus and non-muscle invasive urothelial bladder cancer: Potential relationship from a pilot study. Oncology Reports, 25, 485-489. https://doi.org/10.3892/or.2010.1083
MLA
Cai, T., Mazzoli, S., Meacci, F., Nesi, G., Geppetti, P., Malossini, G., Bartoletti, R."Human papillomavirus and non-muscle invasive urothelial bladder cancer: Potential relationship from a pilot study". Oncology Reports 25.2 (2011): 485-489.
Chicago
Cai, T., Mazzoli, S., Meacci, F., Nesi, G., Geppetti, P., Malossini, G., Bartoletti, R."Human papillomavirus and non-muscle invasive urothelial bladder cancer: Potential relationship from a pilot study". Oncology Reports 25, no. 2 (2011): 485-489. https://doi.org/10.3892/or.2010.1083