Periostin, a matrix specific protein, is associated with proliferation and invasion of pancreatic cancer

  • Authors: Qi-Wen Ben, Xiao-Long Jin, Jun Liu, Xia Cai, Fei Yuan, Yao-Zong Yuan
  • View Affiliations

  • Published online on: Tuesday, January 11, 2011
  • Pages: 709-716
  • DOI: 10.3892/or.2011.1140

Abstract

Overexpression of periostin is present in various malignant tumors and correlates with disease progression. However, its clinicopathological significance in pancreatic cancer is currently not known. Expression of periostin was analyzed by RT-PCR and western blotting in pancreatic cancers and cell lines. Using immunohistochemistry, expression of periostin in pancreatic cancers was evaluated according to factors influencing overall survival with Kaplan-Meier analysis. Ectopic expression of periostin was used to examine the effects of periostin on proliferation and invasiveness of pancreatic cancer cells in vitro. There was no detectable periostin mRNA and protein expression in the 4 pancreatic cell lines. Expression of periostin was found to be up-regulated in pancreatic cancer compared to the adjacent tumor free (TF) tissues by western blotting. The positive ratio of periostin expression in the neoplastic stroma was significantly correlated with the depth of invasion (p=0.007) and lymph node metastasis (p=0.027). Survival analysis showed that stromal or epithelium expression of periostin was associated with poor survival (p=0.035, p=0.022, log-rank test, respectively). In vitro studies showed that periostin was able to promote proliferation and invasiveness of pancreatic cancer cells. These results suggest that periostin may be involved in the progression and invasion of pancreatic cancer.
Journal Cover

March 2011
Volume 25 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Ben, Q., Jin, X., Liu, J., Cai, X., Yuan, F., & Yuan, Y. (2011). Periostin, a matrix specific protein, is associated with proliferation and invasion of pancreatic cancer. Oncology Reports, 25(3), 709-716.
MLA
Ben, Jin, Liu, Cai, Yuan, and Yao-Zong Yuan. "Periostin, a matrix specific protein, is associated with proliferation and invasion of pancreatic cancer." Oncology Reports Oncology Reports 25.3 (2011): 709-716.
Chicago
Ben, Jin, Liu, Cai, Yuan, and Yao-Zong Yuan. "Periostin, a matrix specific protein, is associated with proliferation and invasion of pancreatic cancer." Oncology Reports Oncology Reports 25 no. 3 (2011): 709-716.