Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma

  • Authors:
    • Swe Swe Than
    • Ken Kataoka
    • Masakiyo Sakaguchi
    • Hitoshi Murata
    • Fernando Abarzua
    • Chika Taketa
    • Gang Du
    • Masakazu Yashiro
    • Kazuyoshi Yanagihara
    • Yasutomo Nasu
    • Hiromi Kumon
    • Nam-Ho Huh
  • View Affiliations

  • Published online on: January 18, 2011     https://doi.org/10.3892/or.2011.1149
  • Pages: 989-995
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Abstract

Expression levels of the novel tumor suppressor gene REIC/Dkk-3 are reduced in many human cancers. We have previously showed that an adenovirus vector carrying REIC/Dkk-3 (Ad-REIC) induced apoptosis of cancer cells selectively and exerted bystander antitumor effects via ER stress. We examined possible effects of Ad-REIC in a peritoneal dissemination model of scirrhous gastric carcinoma (SGC). Among various types of gastric cancer, SGC continues to be associated with the worst prognosis due to a high incidence of metastases in the peritoneal cavity. We found that a single intraperitoneal injection of Ad-REIC suppressed tumor dissemination and disease progression. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that Ad-REIC gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC.

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April 2011
Volume 25 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Than SS, Kataoka K, Sakaguchi M, Murata H, Abarzua F, Taketa C, Du G, Yashiro M, Yanagihara K, Nasu Y, Nasu Y, et al: Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma. Oncol Rep 25: 989-995, 2011
APA
Than, S.S., Kataoka, K., Sakaguchi, M., Murata, H., Abarzua, F., Taketa, C. ... Huh, N. (2011). Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma. Oncology Reports, 25, 989-995. https://doi.org/10.3892/or.2011.1149
MLA
Than, S. S., Kataoka, K., Sakaguchi, M., Murata, H., Abarzua, F., Taketa, C., Du, G., Yashiro, M., Yanagihara, K., Nasu, Y., Kumon, H., Huh, N."Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma". Oncology Reports 25.4 (2011): 989-995.
Chicago
Than, S. S., Kataoka, K., Sakaguchi, M., Murata, H., Abarzua, F., Taketa, C., Du, G., Yashiro, M., Yanagihara, K., Nasu, Y., Kumon, H., Huh, N."Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma". Oncology Reports 25, no. 4 (2011): 989-995. https://doi.org/10.3892/or.2011.1149