Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma

  • Authors:
    • Ming-Hua Ge
    • Chao Chen
    • Jia-Jie Xu
    • Zhi-Qiang Ling
  • Corresponding author:
  • View Affiliations

  • Published online on: Thursday, April 28, 2011
  • Pages: 349-357 DOI: 10.3892/or.2011.1282

Abstract

To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the corresponding normal salivary glands, respectively, achieving a significant difference (P<0.001). There was a significant correlation between RUNX3 methylation and various clinicopathological parameters of ACCs, such as perineural invasion, lymph node involvement, T-stage and distant metastasis (P<0.001). RUNX3 methylation was a significant predictor of the 5-year disease-free survival in ACC patients after surgery. Partial methylation was found in all 3 ACC cell lines, and the reactivation and more potent expression of RUNX3 was induced by 5-triazole-2-deoxycytidine. Our findings indicate that RUNX3 methylation may occur as a common event in the development of ACC and that methylation may be a major mechanism for inactivation of RUNX3 in ACC.
Journal Cover

August 2011
Volume 26 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

2014 Impact Factor: 2.301
Ranked #31/211 Oncology
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APA
Ge, M., Chen, C., Xu, J., & Ling, Z. (2011). Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma. Oncology Reports, 26, 349-357. http://dx.doi.org/10.3892/or.2011.1282
MLA
Ge, M., Chen, C., Xu, J., Ling, Z."Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma". Oncology Reports 26.2 (2011): 349-357.
Chicago
Ge, M., Chen, C., Xu, J., Ling, Z."Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma". Oncology Reports 26, no. 2 (2011): 349-357. http://dx.doi.org/10.3892/or.2011.1282