Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma

  • Authors:
    • Abdel-Rahman N. Zekri
    • Abeer A. Bahnassy
    • Hanaa M. Alam El-Din
    • Heba M. Morsy
    • Sabry Shaarawy
    • Nagia Z. Moharram
    • Sayed S. Daoud
  • Corresponding author:
  • View Affiliations

  • Published online on: Tuesday, June 21, 2011
  • Pages: 825-831
  • DOI: 10.3892/or.2011.1355

Abstract

The global rising incidence of hepatocellular carcinoma (HCC), which parallels the increase of hepatitis C virus (HCV) prevalence, has sparked a renewed interest in discovering additional HCC serum markers. In this study, we investigated the clinical use of serum E-cadherin, ICAM, MMP-2, VEGF, OPN and β-catenin as potential diagnostic makers for HCV/genotype 4-associated HCC. Twenty cases of healthy subjects, 11 cases with asymptomatic HCV/genotype 4 carriers (ASC), 28 chronic hepatitis (CH) cases and 32 patients with HCC were enrolled in this study. Serum levels of proteins were measured by a sandwich-enzyme-linked (ELISA) assay. The diagnostic accuracy of each candidate marker was evaluated using receiver-operating characteristic (ROC) curve analysis, reporting the area under the curve (AUC) and its 95% confidence interval (CI). We demonstrated that serum β-catenin levels were significantly elevated in patients with HCC compared to those with CH, ASC and healthy controls. Among the six studied markers, β-catenin was also found to be the only marker that can significantly discriminate between patients with HCC and those with CH; therefore, β-catenin could be considered as a potential marker for early diagnosis of HCV-associated HCC in patients infected with HCV genotype 4.
Journal Cover

October 2011
Volume 26 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Zekri, A.N., Bahnassy, A.A., Alam El-Din, H.M., Morsy, H.M., Shaarawy, S., Moharram, N.Z., & Daoud, S.S. (2011). Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma. Oncology Reports, 26, 825-831. http://dx.doi.org/10.3892/or.2011.1355
MLA
Zekri, A. N., Bahnassy, A. A., Alam El-Din, H. M., Morsy, H. M., Shaarawy, S., Moharram, N. Z., Daoud, S. S."Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma". Oncology Reports 26.4 (2011): 825-831.
Chicago
Zekri, A. N., Bahnassy, A. A., Alam El-Din, H. M., Morsy, H. M., Shaarawy, S., Moharram, N. Z., Daoud, S. S."Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma". Oncology Reports 26, no. 4 (2011): 825-831. http://dx.doi.org/10.3892/or.2011.1355