Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma

  • Authors: Abdel-Rahman N. Zekri, Abeer A. Bahnassy, Hanaa M. Alam El-Din, Heba M. Morsy, Sabry Shaarawy, Nagia Z. Moharram, Sayed S. Daoud
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  • Published online on: Tuesday, June 21, 2011
  • Pages: 825-831
  • DOI: 10.3892/or.2011.1355

Abstract

The global rising incidence of hepatocellular carcinoma (HCC), which parallels the increase of hepatitis C virus (HCV) prevalence, has sparked a renewed interest in discovering additional HCC serum markers. In this study, we investigated the clinical use of serum E-cadherin, ICAM, MMP-2, VEGF, OPN and β-catenin as potential diagnostic makers for HCV/genotype 4-associated HCC. Twenty cases of healthy subjects, 11 cases with asymptomatic HCV/genotype 4 carriers (ASC), 28 chronic hepatitis (CH) cases and 32 patients with HCC were enrolled in this study. Serum levels of proteins were measured by a sandwich-enzyme-linked (ELISA) assay. The diagnostic accuracy of each candidate marker was evaluated using receiver-operating characteristic (ROC) curve analysis, reporting the area under the curve (AUC) and its 95% confidence interval (CI). We demonstrated that serum β-catenin levels were significantly elevated in patients with HCC compared to those with CH, ASC and healthy controls. Among the six studied markers, β-catenin was also found to be the only marker that can significantly discriminate between patients with HCC and those with CH; therefore, β-catenin could be considered as a potential marker for early diagnosis of HCV-associated HCC in patients infected with HCV genotype 4.
Journal Cover

October 2011
Volume 26 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Zekri, A., Bahnassy, A., Alam El-Din, H., Morsy, H., Shaarawy, S., Moharram, N., & Daoud, S. (2011). Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma. Oncology Reports, 26(4), 825-831.
MLA
Zekri, Bahnassy, Alam El-Din, Morsy, Shaarawy, Moharram, and Sayed Daoud. "Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma." Oncology Reports Oncology Reports 26.4 (2011): 825-831.
Chicago
Zekri, Bahnassy, Alam El-Din, Morsy, Shaarawy, Moharram, and Sayed Daoud. "Serum levels of β-catenin as a potential marker for genotype 4/hepatitis C-associated hepatocellular carcinoma." Oncology Reports Oncology Reports 26 no. 4 (2011): 825-831.