Temozolomide decreases invasion of glioma stem cells by down-regulating TGF-β2

  • Authors: Dongyong Zhang, Zhitao Jing, Bo Qiu, Anhua Wu, Yunjie Wang
  • View Affiliations

  • Published online on: Monday, June 27, 2011
  • Pages: 901-908
  • DOI: 10.3892/or.2011.1362

Abstract

Gliomas are characterized by excessive proliferation, diffuse infiltration and immunosuppression. Recent studies implicate a key role for a restricted population of glioma stem cells (GSCs) in glioma invasive growth and recurrence. Transforming growth factor (TGF)-β2 is a mediator of immunosuppression associated with malignant glioma and also influences pro-invasive functions. Temozolomide (TMZ), is a new alkylating agent with promising antitumour efficacy for malignant gliomas, and the effect of TMZ on GSCs invasion has not been known. To address this issue, we developed studies aimed at neurospheres from primary cultured glioma cells, due to the fact that since neurospheres can be enriched in GSCs, we could examine whether TMZ inhibits the invasion of GSCs. TMZ reduced the TGF-β2-mediated invasion, and down-regulated TGF-β2 expression at the mRNA and protein levels. Thus, these results indicate that TMZ, as a chemotherapeutic agent, can reduce the invasion of GSCs and their immunosuppressive activity. TMZ may be used as an immunomodulating agent for glioma therapy.
Journal Cover

October 2011
Volume 26 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Zhang, D., Jing, Z., Qiu, B., Wu, A., & Wang, Y. (2011). Temozolomide decreases invasion of glioma stem cells by down-regulating TGF-β2. Oncology Reports, 26(4), 901-908.
MLA
Zhang, Jing, Qiu, Wu, and Yunjie Wang. "Temozolomide decreases invasion of glioma stem cells by down-regulating TGF-β2." Oncology Reports Oncology Reports 26.4 (2011): 901-908.
Chicago
Zhang, Jing, Qiu, Wu, and Yunjie Wang. "Temozolomide decreases invasion of glioma stem cells by down-regulating TGF-β2." Oncology Reports Oncology Reports 26 no. 4 (2011): 901-908.