Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors

  • Authors:
    • Kyoichi Kaira
    • Yasuhisa Ohde
    • Masahiro Endo
    • Kazuo Nakagawa
    • Takehiro Okumura
    • Toshiaki Takahashi
    • Haruyasu Murakami
    • Asuka Tsuya
    • Yukiko Nakamura
    • Tateaki Naito
    • Haruhiko Kondo
    • Takashi Nakajima
    • Nobuyuki Yamamoto
  • View Affiliations

  • Published online on: Monday, July 11, 2011
  • Pages: 931-937
  • DOI: 10.3892/or.2011.1384

Abstract

4F2hc (CD98) has been associated with tumor growth, and is highly expressed in various tumors. The aim of this study was to evaluate the clinicopathological significance of 4F2hc expression in pulmonary neuroendocrine (NE) tumors. Surgically-resected patient tumors including 16 large cell neuroendocrine carcinoma (LCNEC), 12 small cell lung cancer (SCLC), 1 atypical carcinoid (AC) and 5 typical carcinoid (TC) samples were included in this study. Tumor sections were immunohistochemically stained for 4F2hc (CD98), glucose transporter 1 (Glut1) and 3 (Glut3), hypoxia-inducible factor-1α (HIF-1α), hexokinase I, vascular endothelial growth factor (VEGF), microvessel density (CD34), epidermal growth factor receptor (EGFR), Akt/mammalian target of rapamycin (mTOR) signaling pathway (p-Akt, p-mTOR and p-S6K) and for a cell cycle regulator (p53). 4F2hc was overexpressed in 0% of the pulmonary carcinoids (TCs and ACs), 62.5% of the LCNECs and 50.0% of the SCLCs. A positive 4F2hc expression was significantly associated with age, histology and Glut1 expression. Moreover, a significant correlation was found between 4F2hc expression, and Glut1, HIF-1α, p-Akt, p-mTOR and p-S6K. The expression of 4F2hc was also significantly associated with poor overall survival. The expression of 4F2hc expression tended to increase from low-grade to high-grade pulmonary NE tumors. Our results suggest that 4F2hc may play a significant role in tumor progression, hypoxic conditions and poor outcome in patients with pulmonary NE tumors.
Journal Cover

October 2011
Volume 26 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Kaira, K., Ohde, Y., Endo, M., Nakagawa, K., Okumura, T., Takahashi, T., Murakami, H., Tsuya, A., Nakamura, Y., Naito, T., Kondo, H., Nakajima, T., & Yamamoto, N. (2011). Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors . Oncology Reports, 26(4), 931-937.
MLA
Kaira, Ohde, Endo, Nakagawa, Okumura, Takahashi, Murakami, Tsuya, Nakamura, Naito, Kondo, Nakajima, and Nobuyuki Yamamoto. "Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors ." Oncology Reports Oncology Reports 26.4 (2011): 931-937.
Chicago
Kaira, Ohde, Endo, Nakagawa, Okumura, Takahashi, Murakami, Tsuya, Nakamura, Naito, Kondo, Nakajima, and Nobuyuki Yamamoto. "Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors ." Oncology Reports Oncology Reports 26 no. 4 (2011): 931-937.