Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways

  • Authors: Shih-Ping Cheng, Pen-Hui Yin, Yi-Chiung Hsu, Yuan-Ching Chang, Shih-Yuan Huang, Jie-Jen Lee, Chin-Wen Chi
  • View Affiliations

  • Published online on: Tuesday, July 12, 2011
  • Pages: 1265-1271
  • DOI: 10.3892/or.2011.1388

Abstract

The incidence of thyroid cancer has remarkably increased in recent years. Epidemiologic data suggest that obesity is associated with an increased incidence of several types of malignancies, including thyroid cancer. Leptin, an adipocyte-derived cytokine, has been shown to be involved in cancer development and progression. We previously demonstrated that papillary thyroid cancer expressing leptin receptor and/or leptin has a higher incidence of lymph node metastasis. In this study, we investigated the effects of leptin on cell migration in K1 and B-CPAP papillary thyroid cancer cells. Expression of leptin receptor was observed in both cell lines. Leptin enhanced the migratory activity significantly in a dose-dependent manner. We showed that leptin induced AKT and extracellular signal-regulated kinase (ERK) phosphorylation. Inhibition of phosphatidylinositol 3-kinase and ERK activation using pharmacological inhibitors effectively blocked leptin-induced migration of K1 and B-CPAP cells. Taken together, this study provides new mechanistic evidence for a role of leptin in the regulation of papillary thyroid cancer progression by stimulating tumor cell migration.
Journal Cover

November 2011
Volume 26 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #36/196 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Cheng, S., Cheng, S., Yin, P., Yin, P., Hsu, Y., Hsu, Y., Chang, Y., Chang, Y., Huang, S., Huang, S., Lee, J., Lee, J., Chi, C., & Chi, C. (2011). Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways. Oncology Reports, 26(5), 1265-1271.
MLA
Cheng, Cheng, Yin, Yin, Hsu, Hsu, Chang, Chang, Huang, Huang, Lee, Lee, Chi, and Chin-Wen Chi. "Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways." Oncology Reports Oncology Reports 26.5 (2011): 1265-1271.
Chicago
Cheng, Cheng, Yin, Yin, Hsu, Hsu, Chang, Chang, Huang, Huang, Lee, Lee, Chi, and Chin-Wen Chi. "Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways." Oncology Reports Oncology Reports 26 no. 5 (2011): 1265-1271.