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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2011 Volume 26 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 26 Issue 5

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Article

miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3

  • Authors:
    • Chun-Guang Fan
    • Chun-Mei Wang
    • Chuan Tian
    • Yan Wang
    • Li Li
    • Wen-Sheng Sun
    • Rui-Feng Li
    • Yu-Gang Liu

  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, Shandong University School of Medicine, Jinan, P.R. China, Department of Pathophysiology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan 250012, P.R. China
  • Pages: 1281-1286
    |
    Published online on: July 1, 2011
       https://doi.org/10.3892/or.2011.1375
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Abstract

microRNAs (miRNAs) are short, non-coding RNAs with post-transcriptional regulatory functions that participate in diverse biological pathways. miR-122, a liver-specific miRNA, has been found to be down-regulated in hepatocellular carcinoma (HCC) and HCC-derived cell lines. In this study, miR-122 was down-regulated in the hepatitis B virus (HBV)-related HCC cell line HepG2.2.15 compared to HepG2. NDRG3, a member of the N-myc downstream-regulated gene (NDRG) family, was up-regulated in HepG2.2.15 and was identified as a target gene of miR-122. An inverse correlation between the expression of miR-122 and the NDRG3 protein was noted in HBV-related HCC specimens. The transfection of the miR-122 expression vector into the HepG2.2.15 cell line repressed the transcription and expression of NDRG3, which subsequently reversed the malignant phenotype of the cells. The replication of HBV, expression of viral antigens and proliferation of cells were significantly inhibited by restoration of miR-122. The data demonstrate that miR-122 plays an important role in HBV-related hepatocarcinogenesis by targeting NDRG3. Thus, miR-122 and NDRG3 represent key diagnostic markers and potential therapeutic targets for HBV-related HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Fan C, Wang C, Tian C, Wang Y, Li L, Sun W, Li R and Liu Y: miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3. Oncol Rep 26: 1281-1286, 2011.
APA
Fan, C., Wang, C., Tian, C., Wang, Y., Li, L., Sun, W. ... Liu, Y. (2011). miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3. Oncology Reports, 26, 1281-1286. https://doi.org/10.3892/or.2011.1375
MLA
Fan, C., Wang, C., Tian, C., Wang, Y., Li, L., Sun, W., Li, R., Liu, Y."miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3". Oncology Reports 26.5 (2011): 1281-1286.
Chicago
Fan, C., Wang, C., Tian, C., Wang, Y., Li, L., Sun, W., Li, R., Liu, Y."miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3". Oncology Reports 26, no. 5 (2011): 1281-1286. https://doi.org/10.3892/or.2011.1375
Copy and paste a formatted citation
x
Spandidos Publications style
Fan C, Wang C, Tian C, Wang Y, Li L, Sun W, Li R and Liu Y: miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3. Oncol Rep 26: 1281-1286, 2011.
APA
Fan, C., Wang, C., Tian, C., Wang, Y., Li, L., Sun, W. ... Liu, Y. (2011). miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3. Oncology Reports, 26, 1281-1286. https://doi.org/10.3892/or.2011.1375
MLA
Fan, C., Wang, C., Tian, C., Wang, Y., Li, L., Sun, W., Li, R., Liu, Y."miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3". Oncology Reports 26.5 (2011): 1281-1286.
Chicago
Fan, C., Wang, C., Tian, C., Wang, Y., Li, L., Sun, W., Li, R., Liu, Y."miR-122 inhibits viral replication and cell proliferation in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3". Oncology Reports 26, no. 5 (2011): 1281-1286. https://doi.org/10.3892/or.2011.1375
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