Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers

  • Authors:
    • Takashi Kakimoto
    • Ryosuke Shiraishi
    • Ryuichi Iwakiri
    • Kazuma Fujimoto
    • Hirokazu Takahashi
    • Hiroshi Hamajima
    • Toshihiko Mizuta
    • Hiroyuki Ideguchi
    • Shuji Toda
    • Yoshihiko Kitajima
    • Iwata Ozaki
    • Sachiko Matsuhashi
  • View Affiliations

  • Published online on: September 5, 2011     https://doi.org/10.3892/or.2011.1450
  • Pages: 1385-1392
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Abstract

The expression patterns of PDCD4, a tumor suppressor, and β-catenin were immunohistologically investigated in gastric carcinoma tissues. In normal gastric tissues, PDCD4 was strongly expressed in the cell nuclei, but weakly expressed in the cytoplasm. In gastric adenocarcinoma tissues, nuclear PDCD4 expression was decreased, while cytoplasmic PDCD4 expression was unchanged or somewhat increased. In gastric signet ring cell carcinoma tissues, PDCD4 expression patterns were different from the expression patterns of the adenocarcinoma tissues, and PDCD4 was localized in the nuclei of the carcinoma cells as a belt in the middle of the epithelial layer. The nuclear localization of PDCD4 in the adenocarcinoma tissues was correlated with the membrane localization of β-catenin, the activation of which stimulates invasion of colon cancer cells. PDCD4 expression was correlated with β-catenin expression in gastric carcinoma cell lines, but not with E-cadherin, as the binding partner in the cell membrane.

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December 2011
Volume 26 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kakimoto T, Shiraishi R, Iwakiri R, Fujimoto K, Takahashi H, Hamajima H, Mizuta T, Ideguchi H, Toda S, Kitajima Y, Kitajima Y, et al: Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers. Oncol Rep 26: 1385-1392, 2011.
APA
Kakimoto, T., Shiraishi, R., Iwakiri, R., Fujimoto, K., Takahashi, H., Hamajima, H. ... Matsuhashi, S. (2011). Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers. Oncology Reports, 26, 1385-1392. https://doi.org/10.3892/or.2011.1450
MLA
Kakimoto, T., Shiraishi, R., Iwakiri, R., Fujimoto, K., Takahashi, H., Hamajima, H., Mizuta, T., Ideguchi, H., Toda, S., Kitajima, Y., Ozaki, I., Matsuhashi, S."Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers". Oncology Reports 26.6 (2011): 1385-1392.
Chicago
Kakimoto, T., Shiraishi, R., Iwakiri, R., Fujimoto, K., Takahashi, H., Hamajima, H., Mizuta, T., Ideguchi, H., Toda, S., Kitajima, Y., Ozaki, I., Matsuhashi, S."Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers". Oncology Reports 26, no. 6 (2011): 1385-1392. https://doi.org/10.3892/or.2011.1450