Enhancing effects of immunization with rectal extract on rectal carcinogenesis by local X-irradiation caused in male A/HeJ mice

  • Authors: Y Terada, H Watanabe, N Fujimoto, A Ito
  • View Affiliations

  • Published online on: Monday, July 1, 1996
  • Pages: 707-712
  • DOI: 10.3892/or.3.4.707

Abstract

The influence of preimmunization with a rectal extract on X-irradiation rectal carcinogenesis in the rectum was investigated in male 4-7-week-old A/HeJ mice. They were given 20 Gy per week for a total 40 Gy in the pelvic region with or without 2 prior injections of rectal extract emulsified with complete Freund's adjuvant. Rectal adenocarcinomas were observed in 21 of 34 (62%) immunized animals and in 4 of 22 (18%) non-immunized mice 32 weeks after the last X-irradiation (P<0.01). The total incidences of adenocarcinomas at the 84 week time point were 25/45 (56%) and 12/36 (33%), respectively (P<0.05).
Journal Cover

July 1996
Volume 3 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Terada, Y., Watanabe, H., Fujimoto, N., & Ito, A. (1996). Enhancing effects of immunization with rectal extract on rectal carcinogenesis by local X-irradiation caused in male A/HeJ mice. Oncology Reports, 3(4), 707-712.
MLA
Terada, Watanabe, Fujimoto, and A Ito. "Enhancing effects of immunization with rectal extract on rectal carcinogenesis by local X-irradiation caused in male A/HeJ mice." Oncology Reports Oncology Reports 3.4 (1996): 707-712.
Chicago
Terada, Watanabe, Fujimoto, and A Ito. "Enhancing effects of immunization with rectal extract on rectal carcinogenesis by local X-irradiation caused in male A/HeJ mice." Oncology Reports Oncology Reports 3 no. 4 (1996): 707-712.