Effect of occult hepatitis B virus infection on the early-onset of hepatocellular carcinoma in patients with hepatitis C virus infection

  • Authors: Masahito Nakano, Takumi Kawaguchi, Shingo Nakamoto, Atsushi Kawaguchi, Tatsuo Kanda, Fumio Imazeki, Ryoko Kuromatsu, Shuji Sumie, Manabu Satani, Shingo Yamada, Takuji Torimura, Tatsuyuki Kakuma, Osamu Yokosuka, Michio Sata
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  • Published online on: Tuesday, August 27, 2013
  • Pages: 2049-2055
  • DOI: 10.3892/or.2013.2700

Abstract

Although overt hepatitis B virus (HBV) infection promotes the onset of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV)-infected patients, the effect of occult HBV infection remains unclear. The aim of this study was to investigate the effect of occult HBV infection on the early-onset of HCC in HCV-infected patients. A total of 173 HCC patients with HCV infection were enrolled and classified into 2 groups according to the median age of HCC onset: the early-onset group (n=91; 61.1±5.6 years) and the late-onset group (n=82; 73.8±3.7 years). Independent factors associated with the early-onset of HCC were assessed by multivariate analysis. In the overall analysis, independent risk factors for the early-onset of HCC were the white blood cell count and alanine aminotransferase level, but not the presence of HBV DNA. In a stratification analysis according to albumin levels of ≥3.5 g/dl, the presence of HBV DNA was a significant independent risk factor for the early-onset of HCC (OR 145.18, 95% CI 1.38-15296.61, P=0.036), whereas the presence of antibodies against hepatitis B core antigen was not found to be a risk factor. The presence of HBV DNA was not a risk factor for the early-onset of HCC in the overall analysis. However, its presence was an independent factor for the early-onset of HCC in HCV-infected patients with an albumin level of ≥3.5 g/dl. Thus, occult HBV infection may accelerate hepatocarcino­genesis in HCV-infected patients with relatively low carcinogenic potential.
Journal Cover

November 2013
Volume 30 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Nakano, M., Kawaguchi, T., Nakamoto, S., Kawaguchi, A., Kanda, T., Imazeki, F., Kuromatsu, R., Sumie, S., Satani, M., Yamada, S., Torimura, T., Kakuma, T., Yokosuka, O., & Sata, M. (2013). Effect of occult hepatitis B virus infection on the early-onset of hepatocellular carcinoma in patients with hepatitis C virus infection. Oncology Reports, 30(5), 2049-2055.
MLA
Nakano, Kawaguchi, Nakamoto, Kawaguchi, Kanda, Imazeki, Kuromatsu, Sumie, Satani, Yamada, Torimura, Kakuma, Yokosuka, and Michio Sata. "Effect of occult hepatitis B virus infection on the early-onset of hepatocellular carcinoma in patients with hepatitis C virus infection." Oncology Reports Oncology Reports 30.5 (2013): 2049-2055.
Chicago
Nakano, Kawaguchi, Nakamoto, Kawaguchi, Kanda, Imazeki, Kuromatsu, Sumie, Satani, Yamada, Torimura, Kakuma, Yokosuka, and Michio Sata. "Effect of occult hepatitis B virus infection on the early-onset of hepatocellular carcinoma in patients with hepatitis C virus infection." Oncology Reports Oncology Reports 30 no. 5 (2013): 2049-2055.