BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer

  • Authors:
    • Zhuoxin Cheng
    • Wu Cui
    • Ye Ding
    • Tao Liu
    • Weixin  Liu
    • Youyou  Qin
    • Weibin  Xia
    • Jian  Xu
    • Yinghai  Zhang
    • Xiaoming Zou
  • View Affiliations

  • Published online on: August 18, 2014     https://doi.org/10.3892/or.2014.3413
  • Pages: 1861-1866
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Pancreatic cancer has become one of the most common types of cancer. It is believed that inhibiting the apoptosis of tumor cells as well as overgrowth of tumor cells accelerate the progression and development of cancer. However, the detailed mechanisms of pancreatic cancer progression remain to be fully elucidated. Although bone morphogenetic protein (BMP) families are crucial mediators in some types of cancer, whether BMP8B is involved in regulating the growth and apoptosis of pancreatic cancer cells and the progression of pancreatic cancer is not clear. In the present study, we found that the expression of BMP8B was downregulated in pancreatic cancer tissue compared with the normal tissue adjacent to the tumors. Moreover, the overexpression of BMP8B inhibited cell growth and promoted activation of caspase-3 and -9, the decrease of mitochondrial membrane potential and cell apoptosis in PANC-1, while silencing the BMP8B gene expression with BMP8B shRNA exerted anti-apoptotic effects and boosted the growth of pancreatic cancer cells in BxPC-3. Therefore, we concluded that BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer, making it a potential therapeutic target for pancreatic cancer.
View Figures
View References

Related Articles

Journal Cover

November-2014
Volume 32 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Z, Cui W, Ding Y, Liu T, Liu W, Qin Y, Xia W, Xu J, Zhang Y, Zou X, Zou X, et al: BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer. Oncol Rep 32: 1861-1866, 2014.
APA
Cheng, Z., Cui, W., Ding, Y., Liu, T., Liu, W., Qin, Y. ... Zou, X. (2014). BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer. Oncology Reports, 32, 1861-1866. https://doi.org/10.3892/or.2014.3413
MLA
Cheng, Z., Cui, W., Ding, Y., Liu, T., Liu, W., Qin, Y., Xia, W., Xu, J., Zhang, Y., Zou, X."BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer". Oncology Reports 32.5 (2014): 1861-1866.
Chicago
Cheng, Z., Cui, W., Ding, Y., Liu, T., Liu, W., Qin, Y., Xia, W., Xu, J., Zhang, Y., Zou, X."BMP8B mediates the survival of pancreatic cancer cells and regulates the progression of pancreatic cancer". Oncology Reports 32, no. 5 (2014): 1861-1866. https://doi.org/10.3892/or.2014.3413