Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: Angiogenic markers of neoadjuvant chemoradiation

  • Authors:
    • Han Jo Kim
    • Sang Byung Bae
    • Dongjun Jeong
    • Eun Seog Kim
    • Chang-Nam Kim
    • Dong-Guk Park
    • Tae Sung Ahn
    • Sung Woo Cho
    • Eung Jin Shin
    • Moon Soo Lee
    • Moo Jun Baek
  • View Affiliations

  • Published online on: September 19, 2014     https://doi.org/10.3892/or.2014.3504
  • Pages: 2493-2500
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Abstract

The ability to achieve pathologic downstaging after neoadjuvant chemoradiotherapy (NCRT) is correlated with improved survival in locally advanced rectal cancer (LARC). However, there is no effective predictive markers. In this study, the expression of angiogenic markers was evaluated in pre-treatment biopsies and corresponding post-treatment resection specimens, and were correlated to histopathological tumour characteristics and response. Fifty-five patients with stage II/III rectal cancer treated with 5-fluorouracil (5-FU)-based NCRT were studied. All patients were administered NCRT followed by surgical resection. Immunohistochemical staining for angiogenic markers [hypoxia-inducible factor 1α (HIF‑1α), vascular endothelial growth factor (VEGF), stromal cell‑derived factor 1α (SDF-1α) and placental growth factor (PlGF)] was performed on specimens obtained before NCRT and after surgery. Expression of VEGF, PlGF and HIF-1α protein was downregulated after NCRT in the rectal cancer tissues (P<0.001, P=0.001 and P=0.044, respectively). However, SDF-1α was upregulated after NCRT (P<0.001). Moreover, upregulated expression of SDF-1α (P=0.016) and positive PlGF staining (P=0.001) after NCRT were significantly associated with resistance to NCRT. On multivariate analysis, positive PlGF staining after NCRT was found to be independently associated with resistance to NCRT (P=0.013). Our data suggest that SDF-1α and PlGF should be evaluated as new targets for NCRT in LARC.
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December-2014
Volume 32 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kim HJ, Bae SB, Jeong D, Kim ES, Kim C, Park D, Ahn TS, Cho SW, Shin EJ, Lee MS, Lee MS, et al: Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: Angiogenic markers of neoadjuvant chemoradiation. Oncol Rep 32: 2493-2500, 2014
APA
Kim, H.J., Bae, S.B., Jeong, D., Kim, E.S., Kim, C., Park, D. ... Baek, M.J. (2014). Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: Angiogenic markers of neoadjuvant chemoradiation. Oncology Reports, 32, 2493-2500. https://doi.org/10.3892/or.2014.3504
MLA
Kim, H. J., Bae, S. B., Jeong, D., Kim, E. S., Kim, C., Park, D., Ahn, T. S., Cho, S. W., Shin, E. J., Lee, M. S., Baek, M. J."Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: Angiogenic markers of neoadjuvant chemoradiation". Oncology Reports 32.6 (2014): 2493-2500.
Chicago
Kim, H. J., Bae, S. B., Jeong, D., Kim, E. S., Kim, C., Park, D., Ahn, T. S., Cho, S. W., Shin, E. J., Lee, M. S., Baek, M. J."Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: Angiogenic markers of neoadjuvant chemoradiation". Oncology Reports 32, no. 6 (2014): 2493-2500. https://doi.org/10.3892/or.2014.3504