Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition

Song,Guo-Qing; Zhao,Yi

doi:10.3892/or.2014.3619

Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition

Authors:
- Guo-Qing Song
- Yi Zhao
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Affiliations: Department of Pancreas and Breast Surgery, Shengjing Hospital of China Medical University, Heping, Shenyang, Liaoning 110004, P.R. China
Published online on: November 24, 2014 https://doi.org/10.3892/or.2014.3619
Pages: 669-674

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Abstract

Breast cancer is the leading cause of cancer-related death in women. Kisspeptin-10 (KP-10) is a shorter fragment of KISS1. In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both in vitro and in vivo. KP-10 was observed to induce apoptosis and inhibit the mobility of MDA-MB-231 and MDA-MB-157 cells. Correspondingly, KP-10 suppressed tumor growth in established xenograft tumor models and improved the survival rate of tumor-bearing mice. The formation of intratumoral microvessels was inhibited following treatment with KP-10. Finally, we confirmed that KP-10 inhibited cell mobility via epithelial-mesenchymal transition (EMT). Overall, the present study demonstrated that KP-10 suppressed breast cancer and human umbilical vein endothelial cell (HUVEC) growth both in vivo and in vitro. KP-10 is a novel regulator of EMT in breast cancer cells. However, additional studies are needed to confirm these results in other cell types.

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