High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia

Organista-Nava,Jorge; Gómez-Gómez,Yazmín; Illades-Aguiar,Berenice; Del Carmen Alarcón-Romero,Luz; Saavedra-Herrera,Mónica Virginia; Rivera‑Ramírez,Ana Bertha; Garzón-Barrientos,Víctor Hugo; Leyva-Vázquez,Marco Antonio

doi:10.3892/or.2015.3787

High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia

Authors:
- Jorge Organista-Nava
- Yazmín Gómez-Gómez
- Berenice Illades-Aguiar
- Luz Del Carmen Alarcón-Romero
- Mónica Virginia Saavedra-Herrera
- Ana Bertha Rivera‑Ramírez
- Víctor Hugo Garzón-Barrientos
- Marco Antonio Leyva-Vázquez
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Affiliations: Institute of Cellular Physiology, National Autonomous University of Mexico (UNAM), University City, D.F., Mexico, Research Department, State Cancer Institute, ‘Arturo Beltran Ortega’, Acapulco, Guerrero, Mexico, Laboratory of Molecular Biomedicine, School of Chemical-Biological Sciences, Guerrero State University, Chilpancingo, Guerrero, Mexico, Laboratory of Cytopathology, School of Chemical-Biological Sciences, Guerrero State University, Chilpancingo, Guerrero, Mexico
Published online on: February 6, 2015 https://doi.org/10.3892/or.2015.3787
Pages: 1639-1649
Copyright: © Organista-Nava et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

MicroRNAs (miRNAs) play an essential role in the development and progression of acute leukemia (AL). miR-24 promotes the survival of hematopoietic cells. However, little is known concerning the function of miR-24 in human AL. The aim of the present study was to investigate the clinical significance of miR-24 expression in AL. miR-24 expression in 147 patients with AL and 100 healthy individuals was measured by quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR). The results showed that compared with the healthy individuals, the expression of miR-24 in AL patients was significantly higher (p<0.001). In addition, miR-24 was expressed at significantly higher levels in acute myeloid leukemia (AML) patients and at significantly lower levels in acute lymphoblastic leukemia (ALL) (p<0.001). More importantly, Kaplan-Meier analysis showed that AL patients with high miR-24 expression tended to have shorter overall survival (p<0.05). In the multivariate analysis stratified for known prognostic variables, miR-24 was identified as an independent prognostic marker. Our data indicated that miR-24 upregulation was associated with poor prognosis in AL. miR-24 was identified for the first time as an independent marker for predicting the clinical outcome of AL patients.

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