Intrinsic effects of gold nanoparticles on proliferation and invasion activity in SGC-7901 cells

  • Authors:
    • Yucheng Wu
    • Qingqing Zhang
    • Zhongbao Ruan
    • Yigang Yin
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  • Published online on: December 8, 2015     https://doi.org/10.3892/or.2015.4474
  • Pages: 1457-1462
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Abstract

Although biomedical applications of functionalized nanoparticles have taken significant strides, biological characterization of unmodified nanoparticles remains unclear. In the present study, we investigated the cell viability and invasion activity of gastric cancer cells after treatment with gold nanoparticles. The growth of SGC-7901 cells was inhibited significantly after treatment with 5-nm gold nanoparticles, and the cell invasion decreased markedly. These effects were not seen by different size gold nanoparticles (10, 20 and 40 nm). The attenuated invasion activity may be associated with the decreased expression of matrix metalloproteinase 9 and intercellular adhesion molecule-1. These data indicated that the response of SGC-7901 cells to gold nanoparticles was strongly associated with their unique size-dependent physiochemical properties. Therefore, we provided new evidence for the effect of gold nanoparticles on gastric cancer cell proliferation and invasion in vitro, making a contribution to the application of gold nanoparticles to novel therapies in gastric cancer.
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March-2016
Volume 35 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wu Y, Zhang Q, Ruan Z and Yin Y: Intrinsic effects of gold nanoparticles on proliferation and invasion activity in SGC-7901 cells. Oncol Rep 35: 1457-1462, 2016.
APA
Wu, Y., Zhang, Q., Ruan, Z., & Yin, Y. (2016). Intrinsic effects of gold nanoparticles on proliferation and invasion activity in SGC-7901 cells. Oncology Reports, 35, 1457-1462. https://doi.org/10.3892/or.2015.4474
MLA
Wu, Y., Zhang, Q., Ruan, Z., Yin, Y."Intrinsic effects of gold nanoparticles on proliferation and invasion activity in SGC-7901 cells". Oncology Reports 35.3 (2016): 1457-1462.
Chicago
Wu, Y., Zhang, Q., Ruan, Z., Yin, Y."Intrinsic effects of gold nanoparticles on proliferation and invasion activity in SGC-7901 cells". Oncology Reports 35, no. 3 (2016): 1457-1462. https://doi.org/10.3892/or.2015.4474