miR-215 functions as a tumor suppressor in epithelial ovarian cancer through regulation of the X-chromosome-linked inhibitor of apoptosis

  • Authors:
    • Guanqun Ge
    • Wei Zhang
    • Ligang Niu
    • Yu Yan
    • Yu Ren
    • Yuliang Zou
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  • Published online on: December 9, 2015     https://doi.org/10.3892/or.2015.4482
  • Pages: 1816-1822
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Abstract

Epithelial ovarian cancer (EOC) accounts for 90% of all ovarian cancer, which is the third most common gynaecological malignancy worldwide. Dysregulation of miRNAs is involved in the development of different types of EOC. The present study was designed to investigate the role of abnormal expression of miR-215 in the development of EOC and to elucidate the possible molecular mechanisms. mRNA expression of miR-215 was significantly decreased in EOC tissues and cell lines. Upregulation of miR-215 inhibited cell proliferation, promoted apoptosis and increased sensitivity to chemotherapy drugs in EOC cells. In contrast, downregulation of miR-215 increased cell proliferation, inhibited apoptosis and decreased sensitivity to chemotherapy drugs in EOC cells. In addition, the X-chromosome-linked inhibitor of apoptosis (XIAP) expression was significantly increased in EOC tissues and cell lines. Downregulation of XIAP inhibited cell proliferation, promoted apoptosis and increased sensitivity to chemotherapy drugs in EOC cells. Upregulation of miR-215 notably inhibited the expression of XIAP. Moreover, overexpression of XIAP significantly inhibited miR-215-exerted decrease of proliferation, increase of apoptosis and increase of sensitivity to chemotherapy drugs. In conclusion, we identified miR-215 as a potential tumor suppressor in patients with EOC downregulating expression of the oncogenic regulator XIAP. The data demonstrate that miR-215/XIAP pathway may serve as novel therapeutic targets and prognostic markers in patients with EOC.
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March-2016
Volume 35 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ge G, Zhang W, Niu L, Yan Y, Ren Y and Zou Y: miR-215 functions as a tumor suppressor in epithelial ovarian cancer through regulation of the X-chromosome-linked inhibitor of apoptosis. Oncol Rep 35: 1816-1822, 2016.
APA
Ge, G., Zhang, W., Niu, L., Yan, Y., Ren, Y., & Zou, Y. (2016). miR-215 functions as a tumor suppressor in epithelial ovarian cancer through regulation of the X-chromosome-linked inhibitor of apoptosis. Oncology Reports, 35, 1816-1822. https://doi.org/10.3892/or.2015.4482
MLA
Ge, G., Zhang, W., Niu, L., Yan, Y., Ren, Y., Zou, Y."miR-215 functions as a tumor suppressor in epithelial ovarian cancer through regulation of the X-chromosome-linked inhibitor of apoptosis". Oncology Reports 35.3 (2016): 1816-1822.
Chicago
Ge, G., Zhang, W., Niu, L., Yan, Y., Ren, Y., Zou, Y."miR-215 functions as a tumor suppressor in epithelial ovarian cancer through regulation of the X-chromosome-linked inhibitor of apoptosis". Oncology Reports 35, no. 3 (2016): 1816-1822. https://doi.org/10.3892/or.2015.4482