|Expression of heat shock protein 70 and p53 in human lung cancer|
Authors: M Costa, S Rosas, A Chindano, P Lima, K Madi, M Carvalho
Affiliations: UNIV FED RIO DE JANEIRO,INST BIOFIS CARLOS CHAGAS FILHO,LAB CONTROLE EXPRESSAO GEN,BR-21949900 RIO JANEIRO,BRAZIL. UNIV FED RIO DE JANEIRO,HOSP UNIV CLEMENTINO FRAGA FILHO,DEPT CLIN MED,SERV PNEUMOL,BR-21949900 RIO JANEIRO,BRAZIL. UNIV FED RIO DE JANEIRO,DEPT PATHOL,SERV ANAT PATOL,BR-21949900 RIO JANEIRO,BRAZIL.
Bronchial biopsies of 21 patients with lung cancer were analyzed by Western blot for stress protein HSP70 and p53 proteins. Squamous carcinoma was the most common type found. The p53 protein was detectable in 14 cases. The HSP70 was detectable in 17 and overexpressed in 9 patients. Eleven patients showed positivity for both protein expressions, however no statistical significance was found (Kappa's test, p>0.05). Specific associations were not observed for HSP70 overexpression and p53 detection that could be related to clinical finds or tabagism. Our results indicate that the stress protein HSP70 is detectable and may be involved in the tumor development.