Expression of heat shock protein 70 and p53 in human lung cancer

  • Authors:
    • M Costa
    • S Rosas
    • A Chindano
    • P Lima
    • K Madi
    • M Carvalho
  • View Affiliations

  • Published online on: Monday, September 1, 1997
  • Pages: 1113-1116
  • DOI: 10.3892/or.4.5.1113

Abstract

Bronchial biopsies of 21 patients with lung cancer were analyzed by Western blot for stress protein HSP70 and p53 proteins. Squamous carcinoma was the most common type found. The p53 protein was detectable in 14 cases. The HSP70 was detectable in 17 and overexpressed in 9 patients. Eleven patients showed positivity for both protein expressions, however no statistical significance was found (Kappa's test, p>0.05). Specific associations were not observed for HSP70 overexpression and p53 detection that could be related to clinical finds or tabagism. Our results indicate that the stress protein HSP70 is detectable and may be involved in the tumor development.
Journal Cover

September 1997
Volume 4 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Costa, M., Rosas, S., Chindano, A., Lima, P., Madi, K., & Carvalho, M. (1997). Expression of heat shock protein 70 and p53 in human lung cancer. Oncology Reports, 4(5), 1113-1116.
MLA
Costa, Rosas, Chindano, Lima, Madi, and M Carvalho. "Expression of heat shock protein 70 and p53 in human lung cancer." Oncology Reports Oncology Reports 4.5 (1997): 1113-1116.
Chicago
Costa, Rosas, Chindano, Lima, Madi, and M Carvalho. "Expression of heat shock protein 70 and p53 in human lung cancer." Oncology Reports Oncology Reports 4 no. 5 (1997): 1113-1116.