Activity of cytotoxic agents against clear cell carcinoma of the ovary which is intrinsically platinum-refractory

  • Authors: Y Shimizu, H Nagata, S Umezawa, M Nishida, Y Kikuchi, K Hasumi, T Yokokura
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  • Published online on: Monday, September 1, 1997
  • Pages: 945-948
  • DOI: 10.3892/or.4.5.945

Abstract

The aim of the present study was to evaluate cytotoxic agents active for clear cell carcinoma of the ovary (OCCA) which is intrinsically platinum-resistant. We first conducted in vitro chemosensitivity tests assessing antitumor activities of Various agents against OCCA using two cell lines (HAC-2 and KK) established from ascites of patients with pure OCCA. The most potent single agent was SN-38 (active substance of CPT-11 in vivo) in both cell lines. The second most potent agent was mitomycin-C (MMC) followed by doxorubicin (DOX) in HAC-2 and DOX followed by MMC in KK, respectively. In vivo chemosensitivity test of agents on HAC-2 transplanted into BALB/C nude mice demonstrated that MMC was most potent, followed by DOX and CPT-11. Moreover, a combination of CPT-11 and MMC exhibited the highest anti-tumor activity in this animal model. Cisplatin, etoposide, and paclitaxel were found to be ineffective in either the in vitro or in vivo experimental system. Clinical trial with a combination of MMC and CPT-11 are warranted in patients with OCCA.
Journal Cover

September 1997
Volume 4 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.191
Ranked #33/202 Oncology
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APA
Shimizu, Y., Nagata, H., Umezawa, S., Nishida, M., Kikuchi, Y., Hasumi, K., & Yokokura, T. (1997). Activity of cytotoxic agents against clear cell carcinoma of the ovary which is intrinsically platinum-refractory. Oncology Reports, 4(5), 945-948.
MLA
Shimizu, Nagata, Umezawa, Nishida, Kikuchi, Hasumi, and T Yokokura. "Activity of cytotoxic agents against clear cell carcinoma of the ovary which is intrinsically platinum-refractory." Oncology Reports Oncology Reports 4.5 (1997): 945-948.
Chicago
Shimizu, Nagata, Umezawa, Nishida, Kikuchi, Hasumi, and T Yokokura. "Activity of cytotoxic agents against clear cell carcinoma of the ovary which is intrinsically platinum-refractory." Oncology Reports Oncology Reports 4 no. 5 (1997): 945-948.