The effect of hydrazine sulfate on prostate cancer growth.

  • Authors:
    • J M Kamradt
    • K J Pienta
  • View Affiliations

  • Published online on: Wednesday, July 1, 1998
  • Pages: 919-940
  • DOI: 10.3892/or.5.4.919

Abstract

Prostate cancer remains the most commonly diagnosed cancer in American males and is the second leading cause of cancer death in this group. Hydrazine sulfate, an inhibitor of gluconeogenesis, has been proposed as a means to improve nutritional status and improve survival in patients with solid tumors. We investigated the effects of hydrazine sulfate on both in vitro and in vivo models of prostate cancer. We examined the cytotoxicity of hydrazine sulfate in both human (LNCaP and PC-3) and animal (MAT-LyLu) prostate cancer cell lines. No growth inhibition was observed. In vivo, hydrazine sulfate did not suppress the growth of implanted Dunning rat prostate MAT-LyLu cells. Hydrazine sulfate does not have activity in these models of prostate cancer and may not be an appropriate therapy for patients with prostate cancer.
Journal Cover

July 1998
Volume 5 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

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APA
Kamradt, J., & Pienta, K. (1998). The effect of hydrazine sulfate on prostate cancer growth.. Oncology Reports, 5(4), 919-940.
MLA
Kamradt, and K J Pienta. "The effect of hydrazine sulfate on prostate cancer growth.." Oncology Reports Oncology Reports 5.4 (1998): 919-940.
Chicago
Kamradt, and K J Pienta. "The effect of hydrazine sulfate on prostate cancer growth.." Oncology Reports Oncology Reports 5 no. 4 (1998): 919-940.