Post-transplantation lymphoproliferative disorder of the T-cell/B-cell type: an unusual manifestation in a renal allograft.

  • Authors:
    • G H Wirnsberger
    • M Ratschek
    • H P Dimai
    • H Holzer
    • A K Mandal
  • Corresponding author:
  • View Affiliations

  • Published online on: Friday, January 1, 1999
  • Pages: 29-61 DOI: 10.3892/or.6.1.29

Abstract

Marked impairment of the cellular immune system predisposes renal transplant recipients to Epstein-Barr virus (EBV) associated clinical syndromes. This can culminate in post-transplantation lymphoproliferative disorders (PTLD) and malignant lymphomas. An unusual PTLD in a 59-year-old renal transplant recipient is reported here. Sonography and CT scan revealed a hypovascular infiltrating tumor mass in the lower pole of the graft which on histopathologic examination revealed a monotonous lymphoid proliferation. T-cell receptor and immunoglobulin heavy chain gene rearrangement as well as immunohistochemical analyses demonstrated a polyclonal origin of atypical lymphatic T- and B-cells. The Epstein-Barr viral genome was detected in the mass by Southern blot analysis, and a primary EBV infection was confirmed by serologic studies. Clinical follow-up showed a tumor-free course till the patient's sudden cardiac death 14 months after the operation.
Journal Cover

January 1999
Volume 6 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
2014 I.F. (Expected) ≥ 2.527 Ranked #33/202 Oncology
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APA
Wirnsberger, G., Ratschek, M., Dimai, H., Holzer, H., & Mandal, A. (1999). Post-transplantation lymphoproliferative disorder of the T-cell/B-cell type: an unusual manifestation in a renal allograft.. Oncology Reports, 6, 29-61. http://dx.doi.org/10.3892/or.6.1.29
MLA
Wirnsberger, G., Ratschek, M., Dimai, H., Holzer, H., Mandal, A."Post-transplantation lymphoproliferative disorder of the T-cell/B-cell type: an unusual manifestation in a renal allograft.". Oncology Reports 6.1 (1999): 29-61.
Chicago
Wirnsberger, G., Ratschek, M., Dimai, H., Holzer, H., Mandal, A."Post-transplantation lymphoproliferative disorder of the T-cell/B-cell type: an unusual manifestation in a renal allograft.". Oncology Reports 6, no. 1 (1999): 29-61. http://dx.doi.org/10.3892/or.6.1.29