Growth inhibition of human breast cancer cells by herbs and phytoestrogens.

  • Authors: D Dixon-Shanies, N Shaikh
  • View Affiliations

  • Published online on: Monday, November 1, 1999
  • Pages: 1383-1390
  • DOI: 10.3892/or.6.6.1383

Abstract

Epidemiologic studies have suggested that consumption of phytoestrogen-rich foods may protect against breast cancer, and phytoestrogens such as genistein have been reported to both inhibit and stimulate the growth of some human breast cancer cells. The phytoestrogens genistein, daidzein, biochanin A, and coumestrol were tested and found to inhibit serum-stimulated growth in both T-47D and MCF-7 breast cancer cells at 10-100 microM. Extracts of several estrogenic herbs, including hops, black cohosh and vitex, inhibited growth of T-47D cells. These in vitro results suggest that certain herbs and phytoestrogens may have potential in the prevention of breast cancer.
Journal Cover

November 1999
Volume 6 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

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APA
Dixon-Shanies, D., & Shaikh, N. (1999). Growth inhibition of human breast cancer cells by herbs and phytoestrogens.. Oncology Reports, 6(6), 1383-1390.
MLA
Dixon-Shanies, and N Shaikh. "Growth inhibition of human breast cancer cells by herbs and phytoestrogens.." Oncology Reports Oncology Reports 6.6 (1999): 1383-1390.
Chicago
Dixon-Shanies, and N Shaikh. "Growth inhibition of human breast cancer cells by herbs and phytoestrogens.." Oncology Reports Oncology Reports 6 no. 6 (1999): 1383-1390.