Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.

  • Authors:
    • T Ikeda
    • K Yoshinaga
    • S Semba
    • E Kondo
    • H Ohmori
    • A Horii
  • View Affiliations

  • Published online on: March 1, 2000     https://doi.org/10.3892/or.7.2.323
  • Pages: 323-329
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Abstract

Recently, CTNNB1 (beta-catenin) has been found to function as an oncoprotein that works in the Wnt signaling pathway, and mutation of this gene has been reported in various human cancers. In this study, we analyzed 44 endometrial cancers and found somatic missense mutations in five (11%) tumors. Interestingly, four (80%) of the five tumors with mutations would cause amino acid alterations at residues next to Ser 33, one of the targets for phosphorylation of glycogen synthase kinase (GSK)-3beta. The tumors with mutations showed accumulation of the CTNNB1 protein in cytoplasm and nucleus. This is the first report of frequent somatic mutation of the CTNNB1 gene at codons adjacent to those encoding to Ser/Thr residues in endometrial cancer.

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Mar-Apr 2000
Volume 7 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ikeda T, Yoshinaga K, Semba S, Kondo E, Ohmori H and Horii A: Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.. Oncol Rep 7: 323-329, 2000.
APA
Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., & Horii, A. (2000). Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.. Oncology Reports, 7, 323-329. https://doi.org/10.3892/or.7.2.323
MLA
Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., Horii, A."Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.". Oncology Reports 7.2 (2000): 323-329.
Chicago
Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., Horii, A."Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.". Oncology Reports 7, no. 2 (2000): 323-329. https://doi.org/10.3892/or.7.2.323