Detection of micrometastases in sentinel lymph nodes of the breast applying monoclonal antibodies AE1/AE3 to pancytokeratins.

  • Authors: J H Kowolik, W Kuhn, J Nährig, M Werner, T Obst, N Avril, M Schmitt, H Graeff
  • View Affiliations

  • Published online on: Saturday, July 1, 2000
  • Pages: 745-754
  • DOI: 10.3892/or.7.4.745

Abstract

Sentinel lymph node excision in breast cancer is a minimally invasive diagnostic procedure for accurate staging of the axilla and for avoiding unnecessary axillary dissection. In patients with palpable breast cancer we injected microcolloidal particles of human serum albumin labelled with technetium-99m the day before surgery. The sentinel node was detected intraoperatively with a handheld gammaprobe and then removed. Complete axillary dissection was performed and the nodes inspected by routine histological examination. The axillary lymph node status was correctly predicted by the sentinel node technique in 32 of 33 breast cancer patients. Two cases of micrometastases escaped routine histopathological detection but were identified by immunohistochemical analysis applying the antibody AE1/AE3 to pancytokeratins. Immunohistochemical examination of the sentinel node improves the diagnostic security of patients with breast carcinoma by detection of micrometastases.
Journal Cover

July 2000
Volume 7 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Kowolik, J., Kuhn, W., Nährig, J., Werner, M., Obst, T., Avril, N., Schmitt, M., & Graeff, H. (2000). Detection of micrometastases in sentinel lymph nodes of the breast applying monoclonal antibodies AE1/AE3 to pancytokeratins.. Oncology Reports, 7(4), 745-754.
MLA
Kowolik, Kuhn, Nährig, Werner, Obst, Avril, Schmitt, and H Graeff. "Detection of micrometastases in sentinel lymph nodes of the breast applying monoclonal antibodies AE1/AE3 to pancytokeratins.." Oncology Reports Oncology Reports 7.4 (2000): 745-754.
Chicago
Kowolik, Kuhn, Nährig, Werner, Obst, Avril, Schmitt, and H Graeff. "Detection of micrometastases in sentinel lymph nodes of the breast applying monoclonal antibodies AE1/AE3 to pancytokeratins.." Oncology Reports Oncology Reports 7 no. 4 (2000): 745-754.