Prolongation of survival of rats injected with hepatoma cells treated by nuclei extracts from mouse and rat embryo cells

  • Authors: G. Berger, C. Frayssinet, M. Berger, C. Lafarge Frayssinet
  • View Affiliations

  • Published online on: Tuesday, May 1, 2001
  • Pages: 673-677
  • DOI: 10.3892/or.8.3.673

Abstract

Cancer cells express particular genes, part of which are normally active during the embryonic development. On the other hand, young embryos are able to differentiate teratocarcinoma or leukemia cells, likely by producing differentiation factors. In this work, rat and mouse embryo cell nuclei extracts were tested on hepatoma carcinoma cells LFCl2A: they inhibit the cell growth in culture and increase the survival of syngeneic rats injected with hepatoma cells incubated with these extracts. This inhibition is correlated with a decrease of DNA synthesis without toxic effect: It seems to be due to the mixture of tight binding DNA proteins, possibly transcriptional factors.
Journal Cover

May 2001
Volume 8 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2013 Impact Factor: 2.191
Ranked #33/202 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Berger, G., Frayssinet, C., Berger, M., & Lafarge Frayssinet, C. (2001). Prolongation of survival of rats injected with hepatoma cells treated by nuclei extracts from mouse and rat embryo cells. Oncology Reports, 8(3), 673-677.
MLA
Berger, Frayssinet, Berger, and C. Lafarge Frayssinet. "Prolongation of survival of rats injected with hepatoma cells treated by nuclei extracts from mouse and rat embryo cells." Oncology Reports Oncology Reports 8.3 (2001): 673-677.
Chicago
Berger, Frayssinet, Berger, and C. Lafarge Frayssinet. "Prolongation of survival of rats injected with hepatoma cells treated by nuclei extracts from mouse and rat embryo cells." Oncology Reports Oncology Reports 8 no. 3 (2001): 673-677.