Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line

  • Authors: H. Moteki, H. Hibasami, Y. Yamada, H. Katsuzaki, K. Imai, T. Komiya
  • View Affiliations

  • Published online on: Monday, July 1, 2002
  • Pages: 757-760
  • DOI: 10.3892/or.9.4.757

Abstract

We have investigated the effects of 1,8-cineole [the main component of essential oil prepared from bay-leaves Laurus nobilis L.)] on DNA of human leukemia cell lines, Molt 4B, HL-60 and stomach cancer KATO III cells. Specific induction of apoptosis by 1,8-cineole was observed in human leukemia Molt 4B and HL-60 cells, but not in human stomach cancer KATO III cells. Morphological changes showing apoptotic bodies were observed in the human leukemia HL-60 cells treated with 1,8-cineole. The fragmentations of DNA by cineole to oligonucleosomal-sized fragments that is a characteristic of apoptosis were concentration- and time-dependent in Molt 4B and HL-60 cells, but not in KATO III cells. The present study shows that the suppression growth by 1,8-cineole in the leukemia cell lines results from the induction of apoptosis by this compound.
Journal Cover

July 2002
Volume 9 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2012 Impact Factor: 2.297
Ranked #36/196 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Moteki, H., Hibasami, H., Yamada, Y., Katsuzaki, H., Imai, K., & Komiya, T. (2002). Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line. Oncology Reports, 9(4), 757-760.
MLA
Moteki, Hibasami, Yamada, Katsuzaki, Imai, and T. Komiya. "Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line." Oncology Reports Oncology Reports 9.4 (2002): 757-760.
Chicago
Moteki, Hibasami, Yamada, Katsuzaki, Imai, and T. Komiya. "Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line." Oncology Reports Oncology Reports 9 no. 4 (2002): 757-760.