Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line

  • Authors:
    • H. Moteki
    • H. Hibasami
    • Y. Yamada
    • H. Katsuzaki
    • K. Imai
    • T. Komiya
  • Corresponding author:
  • View Affiliations

  • Published online on: Monday, July 1, 2002
  • Pages: 757-760 DOI: 10.3892/or.9.4.757

Abstract

We have investigated the effects of 1,8-cineole [the main component of essential oil prepared from bay-leaves Laurus nobilis L.)] on DNA of human leukemia cell lines, Molt 4B, HL-60 and stomach cancer KATO III cells. Specific induction of apoptosis by 1,8-cineole was observed in human leukemia Molt 4B and HL-60 cells, but not in human stomach cancer KATO III cells. Morphological changes showing apoptotic bodies were observed in the human leukemia HL-60 cells treated with 1,8-cineole. The fragmentations of DNA by cineole to oligonucleosomal-sized fragments that is a characteristic of apoptosis were concentration- and time-dependent in Molt 4B and HL-60 cells, but not in KATO III cells. The present study shows that the suppression growth by 1,8-cineole in the leukemia cell lines results from the induction of apoptosis by this compound.
Journal Cover

July 2002
Volume 9 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

2014 Impact Factor: 2.301
Ranked #31/211 Oncology
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APA
Moteki, H., Hibasami, H., Yamada, Y., Katsuzaki, H., Imai, K., & Komiya, T. (2002). Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line. Oncology Reports, 9, 757-760. http://dx.doi.org/10.3892/or.9.4.757
MLA
Moteki, H., Hibasami, H., Yamada, Y., Katsuzaki, H., Imai, K., Komiya, T."Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line". Oncology Reports 9.4 (2002): 757-760.
Chicago
Moteki, H., Hibasami, H., Yamada, Y., Katsuzaki, H., Imai, K., Komiya, T."Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line". Oncology Reports 9, no. 4 (2002): 757-760. http://dx.doi.org/10.3892/or.9.4.757