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Journal Cover
May 2010 Volume 23 Issue 5

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Journal Metrics

Impact Factor: 3.9

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review Open Access

Metastatic pancreatic cancer: Is gemcitabine still the best standard treatment? (Review)

Mariacristina Di Marco, Roberto Di Cicilia, Marina Macchini, Elisabetta Nobili, Silvia Vecchiarelli, Giovanni Brandi, Guido Biasco
Pages: 1183-1192
Published online on: 01 May 2010

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Review

Clear cell carcinoma of the ovary: Potential pathogenic mechanisms (Review)

Hirotaka Kajihara, Yoshihiko Yamada, Seiji Kanayama, Naoto Furukawa, Taketoshi Noguchi, Shoji Haruta, Shozo Yoshida, Toshiyuki Sado, Hidekazu Oi, Hiroshi Kobayashi
Pages: 1193-1203
Published online on: 01 May 2010

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Article

SUVmax of FDG-PET correlates with the effects of neoadjuvant chemoradiotherapy for oral squamous cell carcinoma

Akihiko Miyawaki, Ryuji Ikeda, Hiroshi Hijioka, Takayuki Ishida, Mina Ushiyama, Etsuro Nozoe, Norifumi Nakamura
Pages: 1205-1212
Published online on: 01 May 2010

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Article

Molecular subtype can predict the response and outcome of Chinese locally advanced breast cancer patients treated with preoperative therapy

Xiao Song Chen, Jia Yi Wu, Ou Huang, Can Ming Chen, Jiong Wu, Jin Song Lu, Zhi Ming Shao, Zhen Zhou Shen, Kun Wei Shen
Pages: 1213-1220
Published online on: 01 May 2010

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Article

Prognostic significance of CUB domain containing protein expression in endometrioid adenocarcinoma

Suhana Mamat, Jun-ichiro Ikeda, Takayuki Enomoto, Yutaka Ueda, Nur Rahadiani, Tian Tian, Yi Wang, Ying Qiu, Tadashi Kimura, Katsuyuki Aozasa, Eiichi Morii
Pages: 1221-1227
Published online on: 01 May 2010

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Article

The cytological characteristics of small cell change of dysplasia in small hepatic nodules

Okki Chang, Yoshihiko Yano, Akira Masuzawa, Noriyuki Fukushima, Kazuhiro Teramura, Yoshitake Hayashi
Pages: 1229-1232
Published online on: 01 May 2010

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Article

Sorbitol dehydrogenase expression is regulated by androgens in the human prostate

Zoltán Szabó, Jenni Hämäläinen, Ildikó Loikkanen, Anne-Mari Moilanen, Pasi Hirvikoski, Timo Väisänen, Timo K. Paavonen, Markku H. Vaarala
Pages: 1233-1239
Published online on: 01 May 2010

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Article

DNA oxidative damage of neoplastic rat liver lesions

Barbara Marengo, Chiara De Ciusis, Roberta Ricciarelli, Paola Romano, Mario Passalacqua, Umberto M. Marinari, Maria A. Pronzato, Cinzia Domenicotti
Pages: 1241-1246
Published online on: 01 May 2010

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Article

Collagen type I regulates β-catenin tyrosine phosphorylation and nuclear translocation to promote migration and proliferation of gastric carcinoma cells

Aiqing Li, Tianhua Zhou, Lei Guo, Jianmin Si
Pages: 1247-1255
Published online on: 01 May 2010

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Article

Altered expression of Akt signaling pathway parameters in prostate needle biopsies derived from benign, adjacent and cancerous tissue

Sandra Waalkes, Perikles Simon, Jörg Hennenlotter, Judith Knapp, Hossein Tezval, Jürgen Serth, Arnulf Stenzl, Markus A. Kuczyk, Axel S. Merseburger
Pages: 1257-1260
Published online on: 01 May 2010

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Article

Primary testicular lymphoma: A strictly homogeneous hematological disease?

Ralf Kemmerling, Sebastian Stintzing, Josef Mühlmann, Otto Dietze, Daniel Neureiter
Pages: 1261-1267
Published online on: 01 May 2010

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Article

Changes of the O6-methylguanine-DNA methyltransferase promoter methylation and MGMT protein expression after adjuvant treatment in glioblastoma

Tae-Young Jung, Shin Jung, Kyung-Sub Moon, In-Young Kim, Sam-Suk Kang, Young-Hee Kim, Chang-Soo Park, Kyung-Hwa Lee
Pages: 1269-1276
Published online on: 01 May 2010

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Article

Characterization of primary ovarian cancer cells in different culture systems

Te Liu, Weiwei Cheng, Dongmei Lai, Yong Huang, Lihe Guo
Pages: 1277-1284
Published online on: 01 May 2010

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Article

Curcumin induces mitochondria pathway mediated cell apoptosis in A549 lung adenocarcinoma cells

Qing Yong Chen, Guo Hua Lu, Yu Quan Wu, Ying Zheng, Kedi Xu, Li Jun Wu, Zhong Yong Jiang, Rui Feng, Jian Ying Zhou
Pages: 1285-1292
Published online on: 01 May 2010

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Article

Expression of voltage-gated sodium channel α subunit in human ovarian cancer

Rui Gao, Yi Shen, Jing Cai, Ming Lei, Zehua Wang
Pages: 1293-1299
Published online on: 01 May 2010

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Article

Ca2+-binding protein S100A11: A novel diagnostic marker for breast carcinoma

Xiang-Guo Liu, Xiao-Ping Wang, Wan-Feng Li, Shuo Yang, Xin Zhou, Si-Jie Li, Xiang-Jun Li, Dong-Yun Hao, Zhi-Min Fan
Pages: 1301-1308
Published online on: 01 May 2010

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Article

Tumor-targeted efficiency of shRNA vector harboring chimera hTERT/U6 promoter

Penghui Zhang, Yaqin Chen, Xixin Jiang, Zhiguang Tu, Lin Zou
Pages: 1309-1316
Published online on: 01 May 2010

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Article

Differences in prognostic factors according to viral status in patients with hepatocellular carcinoma

Hiroshi Akahoshi, Naota Taura, Tatsuki Ichikawa, Hisamitsu Miyaaki, Motohisa Akiyama, Satoshi Miuma, Eisuke Ozawa, Shigeyuki Takeshita, Toru Muraoka, Toshihisa Matsuzaki, Masashi Ohtani, Hajime Isomoto, Takehiro Matsumoto, Fuminao Takeshima, Kazuhiko Nakao
Pages: 1317-1323
Published online on: 01 May 2010

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Article

Identification of β2-microgloblin as a candidate for early diagnosis of imaging-invisible hepatocellular carcinoma in patient with liver cirrhosis

Yumi Saito, Nobuyuki Oba, Syuta Nishinakagawa, Yasuhiro Mizuguchi, Tatsuya Kojima, Kazuhiro Nomura, Tetsuya Nakatsura
Pages: 1325-1330
Published online on: 01 May 2010

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Article

Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation

Hiroshi Miyata, Makoto Yamasaki, Shuji Takiguchi, Kiyokazu Nakajima, Yoshiyuki Fujiwara, Masaki Mori, Yuichiro Doki
Pages: 1331-1337
Published online on: 01 May 2010

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Article

Pre-radiation enhances the cytotoxicity of docetaxel in head and neck squamous cell carcinoma cells

Satori Furuse, Makoto Adachi, Kei Ijichi, Shinsuke Ohta, Soichiro Torigoe, Masatoshi Nakazawa, Satoshi Miura, Kenji Mitsudo, Iwai Tohnai
Pages: 1339-1343
Published online on: 01 May 2010

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Article

Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer

Michiko Shintani, Makoto Urano, Yasunari Takakuwa, Makoto Kuroda, Shingo Kamoshida
Pages: 1345-1350
Published online on: 01 May 2010

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Article

Paternal monoenergetic neutron exposure results in abnormal sperm, and embryonal lethality and transgenerational tumorigenesis in mouse F1 offspring

Hiromitsu Watanabe, Megumi Toyoshima, Masayori Ishikawa, Kenji Kamiya
Pages: 1351-1360
Published online on: 01 May 2010

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Article

Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population

Chikako Kiyohara, Takahiko Horiuchi, Yoshihiro Miyake, Koichi Takayama, Yoichi Nakanishi
Pages: 1361-1368
Published online on: 01 May 2010

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Article

Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin

Ju Young Kim, Hyun Ki Park, Jin Sun Yoon, Seo Ju Kim, Eun Shil Kim, Sung Heon Song, Jung Hye Choi, Byoung Kook Kim, Byoung Bae Park, Young Yiul Lee
Pages: 1369-1374
Published online on: 01 May 2010

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Article

Side population in the pancreatic cancer cell lines SW1990 and CFPAC-1 is enriched with cancer stem-like cells

Jie Yao, Hui-Hua Cai, Ji-Shu Wei, Yong An, Zhen-Ling Ji, Zi-Peng Lu, Jun-Li Wu, Ping Chen, Kui-Rong Jiang, Cun-Cai Dai, Zhu-Yin Qian, Ze-Kuan Xu, Yi Miao
Pages: 1375-1382
Published online on: 01 May 2010

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Article

Profiling of cell cycle genes of breast cells exposed to etodolac

D. Roy, G. A. Arason, B. Chowdhury, A. Mitra, G. M. Calaf
Pages: 1383-1391
Published online on: 01 May 2010

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Article

Influence of thymidylate synthase DNA polymorphisms and gender on the clinical evolution of patients with advanced colorectal cancer

Maria-Encarnación Fernández-Contreras, José Javier Sánchez-Hernández, Mercedes Guijarro, Javier P. Gisbert, Noa Rivas, María-Luisa García de Paredes, Adolfo Hinojar-Gutiérrez, Carlos Gamallo
Pages: 1393-1400
Published online on: 01 May 2010

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Article

Solanum torvum inhibits Helicobacter pylori growth and mediates apoptosis in human gastric epithelial cells

Yuan-Man Hsu, Jing-Ru Weng, Tsurng-Juhn Huang, Chih-Ho Lai, Chiu-Hsiang Su, Chang-Hung Chou
Pages: 1401-1405
Published online on: 01 May 2010

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Article

A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: Preliminary results

Laurent Schwartz, Mohammad Abolhassani, Adeline Guais, Edward Sanders, Jean-Marc Steyaert, Frederic Campion, Maurice Israël
Pages: 1407-1416
Published online on: 01 May 2010

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Article

The enhanced transcriptional activity of the V-val subtype of Epstein-Barr virus nuclear antigen 1 in epithelial cell lines

Shi-Juan Mai, Dan Xie, Yu-Fan Huang, Feng-Wei Wang, Yi-Ji Liao, Hai-Xia Deng, Wen-Ju Liu, Wen-Feng Hua, Yi-Xin Zeng
Pages: 1417-1424
Published online on: 01 May 2010

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Article

Activation of caspases and apoptosis in response to low-voltage electric pulses

Noriaki Matsuki, Motohiro Takeda, Takuji Ishikawa, Aki Kinjo, Tomoaki Hayasaka, Yohsuke Imai, Takami Yamaguchi
Pages: 1425-1433
Published online on: 01 May 2010

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Article

Synthesis and biological analysis of a new curcumin analogue for enhanced anti-tumor activity in HepG 2 cells

Jian Xiao, Yanhui Chu, Keqiong Hu, Jin Wan, Yi Huang, Chengxi Jiang, Guang Liang, Xiaokun Li
Pages: 1435-1441
Published online on: 01 May 2010

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Article

Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation

Nengjiang Zhao, Ya Guo, Mingfang Zhang, Ling Lin, Zhihong Zheng
Pages: 1443-1447
Published online on: 01 May 2010

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Article

ARL6IP1 mediates cisplatin-induced apoptosis in CaSki cervical cancer cells

Fengjie Guo, Yalin Li, Yan Liu, Jiajia Wang, Guancheng Li
Pages: 1449-1455
Published online on: 01 May 2010

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Article

Inhibition of c-FLIP expression by miR-512-3p contributes to Taxol-induced apoptosis in hepatocellular carcinoma cells

Feng Chen, Hai-Hong Zhu, Lin-Fu Zhou, Shan-Shan Wu, Jing Wang, Zhi Chen
Pages: 1457-1462
Published online on: 01 May 2010

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Article

Aberrant V(D)J cleavages in T cell receptor β enhancer- and p53-deficient lymphoma cells

Yun Hee Kang, Chae-Yeon Son, Chul-Ho Lee, Chun Jeih Ryu
Pages: 1463-1468
Published online on: 01 May 2010

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Article

Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells

Feng Liu, Shiying Liu, Shengnan He, Zhenhua Xie, Xuyu Zu, Yuyang Jiang
Pages: 1469-1475
Published online on: 01 May 2010

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Journal Cover
July-2026 Volume 56 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)

Shuqi Zhang, Ping Li, Lixia Zhu
Article Number: 139
Published online on: 28 May 2026

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Review Open Access

Ferroptosis in colorectal cancer: Molecular mechanisms and regulatory crosstalk with therapeutic prospects (Review)

Mingxing Wu, Mingrong Zhang
Article Number: 138
Published online on: 27 May 2026

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Correction Open Access

[Corrigendum] 17‑AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA‑MB‑231 breast cancer cells

Yu Zuo, Heng Xu, Zhifeng Chen, Fengmin Xiong, Bei Zhang, Kaixian Chen, Hualiang Jiang, Cheng Luo, Hao Zhang
Article Number: 137
Published online on: 27 May 2026

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Review Open Access

Targeting lung cancer with tanshinones: Current mechanistic evidence and emerging opportunities (Review)

Zhengqi Guo, Xiaoci Li, Pengyu Suo, Zhanyu Lin, Ruixin Liu, Chenyu Chi
Article Number: 136
Published online on: 26 May 2026

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Review Open Access

Immune network remodeling driven by ferroptosis: Bidirectional interaction mechanisms among multiple immune cells in the lung cancer immune microenvironment (Review)

Fei Qu, Jiale Tong, Weiwei Qian, Qian He
Article Number: 135
Published online on: 26 May 2026

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Correction Open Access

[Corrigendum] Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression

Lei Zhu, Xiao-Xia Li, Liang Shi, Jing Wu, Jia-Yi Qian, Tian-Song Xia, Wen-Bin Zhou, Xi Sun, Xu-Jie Zhou, Ji-Fu Wei, Qiang Ding
Article Number: 134
Published online on: 20 May 2026

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Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review)

Yuanbo Xu, Weili Wang, Yating Zhang, Yinqiu Fan, Wanying Dong, Jun Yang
Article Number: 133
Published online on: 20 May 2026

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Retraction Open Access

[Retracted] Hsp90 inhibitor 17‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway

Xiong Shu, Huiqi Liu, Rui Zhen, Yongsheng Jie, Lei Chen, Hui Qi, Chao Wang, Renxian Wang, Dafu Chen, Yuliang Ran
Article Number: 132
Published online on: 18 May 2026

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Article Open Access

Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway

Huili Feng, Lixin He, Talha Umar, Haipeng Wang, Yanling Gao, Gongyi Chen, Panfeng Sun, Ling Yin, Wenbin Zhao, Huifang Lu, Ganzhen Deng, Changwei Qiu
Article Number: 131
Published online on: 14 May 2026

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Correction Open Access

[Corrigendum] ENO2 affects the EMT process of renal cell carcinoma and participates in the regulation of the immune micro­environment

Wei-Jie Chen, Wei Yang, Min Gong, Yi He, Da Xu, Jia-Xin Chen, Wen-Jin Chen, Wen-Yan Li, Yu-Qi Wang, Ke-Qin Dong, Xu Song, Xiu-Wu Pan, Xin-Gang Cui
Article Number: 130
Published online on: 13 May 2026

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Article Open Access

SRRT promotes prostate cancer progression and serves as a prognostic biomarker through STAT3 pathway activation

Lingxiang Lu, Ke Wu, Zhenfan Wang, Ruoxi Yang, Kai Li, Shuai Guo, Fei Wang, Zheng Ma
Article Number: 129
Published online on: 13 May 2026

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Retraction Open Access

[Retracted] Hsp72 controls bortezomib‑induced HepG2 cell death via interaction with pro‑apoptotic factors 

Giuseppe Calvaruso, Michela Giuliano, Patrizia Portanova, Ornella Pellerito, Renza Vento, Giovanni Tesoriere
Article Number: 128
Published online on: 11 May 2026

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Article Open Access

Effect of the miR‑26a/b‑5p‑STAT3‑YKL‑40 regulatory axis on proliferation, migration, and invasion of endometrial cancer cells

Xinzhao Sun, Shanshan Lin, Xueyan Zhong, Yanlu Luo, Jiahuang Yang, Jiangtao Fan
Article Number: 127
Published online on: 08 May 2026

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Review Open Access

Cancer signaling networks in tumor progression and drug resistance: Crosstalk, adaptive reprogramming and therapeutic targeting (Review)

Hongyan Li, Shiyuan Song, Linlin Wang, Qiang Liu
Article Number: 126
Published online on: 08 May 2026

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Article Open Access

A novel regulatory role of microRNA‑5590‑3p in hepatocellular carcinoma via the HOXB2/MYC axis

Bin Li, Lin Zhou
Article Number: 125
Published online on: 07 May 2026

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Retraction Open Access

[Retracted] SHIP1 is targeted by miR‑155 in acute myeloid leukemia

Hua Xue, Luo-Ming Hua, Ming Guo, Jian-Min Luo
Article Number: 124
Published online on: 05 May 2026

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Review Open Access

Chronic stress and cancer progression through neuro‑endocrine‑immune networks (Review)

Zhangxiang Zhu, Xiaohu Zhang, Jing Yan, Mingquan Wang, Yang Lv, Wuqiong Zhang, Hui Guo, Aimei Zheng
Article Number: 123
Published online on: 04 May 2026

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Retraction Open Access

[Retracted] PTEN enhances G2/M arrest in etoposide‑treated MCF‑7 cells through activation of the ATM pathway

Ruopeng Zhang, Li Zhu, Lirong Zhang, Anli Xu, Zhengwei Li, Yijuan Xu, Pei He, Maoqing Wu, Fengxiang Wei, Chenhong Wang
Article Number: 122
Published online on: 29 April 2026

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Journal Cover
August-2026 Volume 56 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

A fibroblast activation protein degrader enhances cisplatin sensitivity in non‑small cell lung cancer

Yong Zhou, Ranhua Li, Xiaobo Chen, Cheng Zhang, Yanan Bao, Yue Cui, Xinghe Tong, Ting Xia, Xudong Yang, Jiqing Yang, Xiaochuan Yin
Article Number: 145
Published online on: 10 June 2026

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Review Open Access

Sterol regulatory element‑binding proteins: Master regulators of lipid metabolic reprogramming in cancer and emerging therapeutic targets (Review)

Qing Liu, Rui Wang, Zhenbo Li, Yihan Liu, Lei Wu, Yuqin Zhao, Jing Yang
Article Number: 144
Published online on: 04 June 2026

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Review Open Access

Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review)

Angelina Daher, Zahraa Assi, Amjad Kanaan, Ahmad Al Khatib, Mirvat El Sibai
Article Number: 143
Published online on: 03 June 2026

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Review Open Access

Targeting colorectal cancer and T‑cell metabolism for the treatment of colorectal cancer (Review)

Qiangzong Yu, Pengbo Luan, Jingru Liang, Lixin Wang
Article Number: 142
Published online on: 02 June 2026

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Expression of Concern Open Access

[Expression of Concern] Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells

Wangdi Liao, Guohua Li, Yu You, Hongping Wan, Qiong Wu, Chongwen Wang, Nonghua Lv
Article Number: 141
Published online on: 02 June 2026

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Article Open Access

Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer

Kunkun Han, Qianyun Zhang, Shengnan Gao, Jigang Zhang, Xiao Mei, Fei Li, Xin Xu, Shu Li, Guodong Chen
Article Number: 140
Published online on: 29 May 2026

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