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Journal Cover
July 2010 Volume 24 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

Matrix metalloproteinase-2 and -9 in the urine of prostate cancer patients

Angelina Di Carlo, Angela Mariano, Daniela Terracciano, Matteo Ferro, Vittorino Montanaro, Mariano Marsicano, Giuseppe Di Lorenzo, Vincenzo Altieri, Vincenzo Macchia
Pages: 3-8
Published online on: 01 July 2010

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Article Open Access

Histopathological evaluation including cytokeratin 13 and Ki-67 in the border between Lugol-stained and -unstained areas

Kouji Ohta, Ikuko Ogawa, Shigehiro Ono, Masaaki Taki, Kuniko Mizuta, Miwa Miyauchi, Masaaki Takechi, Hideo Shigeishi, Takashi Takata, Nobuyuki Kamata
Pages: 9-14
Published online on: 01 July 2010

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Article Open Access

Characterization of Pt-, Pd-spermine complexes for their effect on polyamine pathway and cisplatin resistance in A2780 ovarian carcinoma cells

Ramakumar Tummala, Paula Diegelman, Sonia M. Fiuza, Luis A.E. Batista de Carvalho, Maria Paula M. Marques, Debora L. Kramer, Kimberly Clark, Slavoljub Vujcic, Carl W. Porter, Lakshmi Pendyala
Pages: 15-24
Published online on: 01 July 2010

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Article

Two-stage treatment (Mukai's method) with hybrid 2-port HALS (Mukai's operation) for complete bowel obstruction by left colon cancer or rectal cancer

Masaya Mukai, Yasutomo Sekido, Tatsuhiko Hoshikawa, Naoki Yazawa, Hiroshi Fukumitsu, Kazutake Okada, Takayuki Tajima, Masato Nakamura, Kyouji Ogoshi
Pages: 25-30
Published online on: 01 July 2010

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Article

Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2

Nao Ohtsu, Kazuki Takaoka, Emi Segawa, Susumu Hashitani, Kazuma Noguchi, Hiromitsu Kishimoto, Masahiro Urade
Pages: 31-36
Published online on: 01 July 2010

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Article

Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line

H. K. Dibra, J. E. Brown, P. Hooley, I. D. Nicholl
Pages: 37-46
Published online on: 01 July 2010

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Article

Low SMC1A protein expression predicts poor survival in acute myeloid leukemia

Claudia Hömme, Utz Krug, Nicola Tidow, Bernd Schulte, Gabriele Kühler, Hubert Serve, Horst Bürger, Wolfgang E. Berdel, Martin Dugas, Achim Heinecke, Thomas Büchner, Steffen Koschmieder, Carsten Müller-Tidow
Pages: 47-56
Published online on: 01 July 2010

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Article

Identification of serum proteins as prognostic and predictive markers of colorectal cancer using surface enhanced laser desorption ionization-time of flight mass spectrometry

Helgi H. Helgason, Judith Y.M. Engwegen, Marc Zapatka, Andrew Vincent, Annemieke Cats, Henk Boot, Jos H. Beijnen, Jan H.M. Schellens
Pages: 57-64
Published online on: 01 July 2010

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Article

AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion

Junxia Zhang, Lei Han, Anling Zhang, Yingyi Wang, Xiao Yue, Yongping You, Peiyu Pu, Chunsheng Kang
Pages: 65-72
Published online on: 01 July 2010

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Article

Implication of necrosis-linked p53 aggregation in acquired apoptotic resistance to 5-FU in MCF-7 multicellular tumour spheroids

Su Yeon Lee, Eui-Kyong Jeong, Hyun Min Jeon, Cho Hee Kim, Ho Sung Kang
Pages: 73-79
Published online on: 01 July 2010

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Article

Co-regulated expression of matrix metalloproteinase-2 and transforming growth factor-β in melanoma development and progression

Grazia Malaponte, Alessandra Zacchia, Ylenia Bevelacqua, Andrea Marconi, Rosario Perrotta, Maria Clorinda Mazzarino, Vera Cardile, Franca Stivala
Pages: 81-87
Published online on: 01 July 2010

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Article

Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway

Yu-Gang Wen, Quan Wang, Chong-Zhi Zhou, Guo-Qiang Qiu, Zhi-Hai Peng, Hua-Mei Tang
Pages: 89-95
Published online on: 01 July 2010

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Article

Hypoxia-inducible factor-1α modulates the down-regulation of the homeodomain protein CDX2 in colorectal cancer

Jianbao Zheng, Xuejun Sun, Wei Wang, Shaoying Lu
Pages: 97-104
Published online on: 01 July 2010

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Article

Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells

Jian Pan, Hai Hu, Zhuan Zhou, Lichao Sun, Liang Peng, Long Yu, Lixin Sun, Jun Liu, Zhihua Yang, Yuliang Ran
Pages: 105-112
Published online on: 01 July 2010

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Article

Akt associates with nuclear factor κB and plays an important role in chemoresistance of gastric cancer cells

Liang-Liang Yu, Ning Dai, Hong-Gang Yu, Lei-Min Sun, Jian-Min Si
Pages: 113-119
Published online on: 01 July 2010

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Article

Genomic change of chromosome 8 predicts the response to taxane-based neoadjuvant chemotherapy in node-positive breast cancer

Sehwan Han, Kyeongmee Park, Eunah Shin, Hyun-Jung Kim, Jung Yeon Kim, Ji Young Kim, Geumhee Gwak
Pages: 121-128
Published online on: 01 July 2010

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Immunohistochemial evaluation of sarcoglycans and integrins in gingival epithelium of multiple myeloma patients with bisphosphonate-induced osteonecrosis of the jaw

Enrico Nastro Siniscalchi, Giuseppina Cutroneo, Luciano Catalfamo, Giuseppe Santoro, Alessandro Allegra, Giacomo Oteri, Domenico Cicciù, Andrea Alonci, Giuseppa Penna, Caterina Musolino, Francesco Saverio De Ponte, Giuseppe Anastasi, Angelo Favaloro
Pages: 129-134
Published online on: 01 July 2010

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Article

Programmed cell death 4 protein in esophageal cancer

Matteo Fassan, Matteo Cagol, Gianmaria Pennelli, Christian Rizzetto, Luciano Giacomelli, Giorgio Battaglia, Giovanni Zaninotto, Ermanno Ancona, Alberto Ruol, Massimo Rugge
Pages: 135-139
Published online on: 01 July 2010

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Article

Aristolochic acid suppresses DNA repair and triggers oxidative DNA damage in human kidney proximal tubular cells

Ya-Yin Chen, Jing-Gung Chung, Hsiu-Ching Wu, Da-Tian Bau, Kuen-Yuh Wu, Shung-Te Kao, Chien-Yun Hsiang, Tin-Yun Ho, Su-Yin Chiang
Pages: 141-153
Published online on: 01 July 2010

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Article

FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures

Elizabeth F. Martinez, Ana P.D. Demasi, Lucyene Miguita, Albina Altemani, Ney S. Araújo, Vera C. Araújo
Pages: 155-160
Published online on: 01 July 2010

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Article

Validated analysis of HIF-1α expression in cancer cells using a controlled and comparative immunoassay

Maria Ioannou, Ilias Mylonis, Evangelos Kouvaras, Rodula Papamichali, Alexandros Daponte, Efrosyni Paraskeva, George Simos, George K. Koukoulis
Pages: 161-169
Published online on: 01 July 2010

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Article

A variant of estrogen receptor-α, ER-α36 is expressed in human gastric cancer and is highly correlated with lymph node metastasis

Hao Deng, Xuan Huang, Jun Fan, Liubai Wang, Qin Xia, Xiuping Yang, Zhaoyi Wang, Lijiang Liu
Pages: 171-176
Published online on: 01 July 2010

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Article

Photodynamic therapy with hexenyl ester of 5-aminolevulinic acid induces necrotic cell death in salivary gland adenocarcinoma cells

Jong-Hwan Park, Yeon-Hee Moon, Dong-Jae Kim, Soo-A Kim, Jee-Bum Lee, Sang-Gun Ahn, Jung-Hoon Yoon
Pages: 177-181
Published online on: 01 July 2010

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Article

HSG provides antitumor efficacy on hepatocellular carcinoma both in vitro and in vivo

Weilin Wang, Feng Zhu, Shuqian Wang, Jianfeng Wei, Changku Jia, Yuanbiao Zhang, Lin Zhou, Haiyang Xie, Shusen Zheng
Pages: 183-188
Published online on: 01 July 2010

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Article

c-Met antisense oligodeoxynucleotides increase sensitivity of human glioma cells to paclitaxel

Sheng-Hua Chu, Yan-Bin Ma, Dong-Fu Feng, Hong Zhang, Jian-Hua Qiu, Zhi-An Zhu
Pages: 189-194
Published online on: 01 July 2010

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Article

Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3

Xuan Zhou, Junxia Zhang, Qiang Jia, Yu Ren, Yingyi Wang, Lei Shi, Ning Liu, Guangxiu Wang, Peiyu Pu, Yongping You, Chunsheng Kang
Pages: 195-201
Published online on: 01 July 2010

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Article

Human tissue-specific microenvironment: An essential requirement for mouse models of breast cancer

Tian-Song Xia, Jue Wang, Hong Yin, Qiang Ding, Yi-Fen Zhang, Hai-Wei Yang, Xiao-An Liu, Min Dong, Qing Du, Li-Jun Ling, Xiao-Ming Zha, Wei Fu, Shui Wang
Pages: 203-211
Published online on: 01 July 2010

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Article Open Access

Effects of the ErbB1/ErbB2 kinase inhibitor GW2974 on androgen-independent prostate cancer PC-3 cell line growth and NSE, chromogranin A and osteopontin content

Daniela Terracciano, Claudia Mazzarella, Angelina Di Carlo, Angela Mariano, Matteo Ferro, Giuseppe Di Lorenzo, Antonio Giordano, Vincenzo Altieri, Sabino De Placido, Vincenzo Macchia
Pages: 213-217
Published online on: 01 July 2010

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Article

Spindle cells from AIDS-associated Kaposi's sarcoma lesions express telomerase activity that is enhanced by Kaposi's sarcoma progression factors

Giovanni Barillari, Ornella Franzese, Alessandro Comandini, Enzo Bonmassar, Barbara Ensoli
Pages: 219-223
Published online on: 01 July 2010

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Article

Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway

Nozomi Nomi, Satoru Kodama, Masashi Suzuki
Pages: 225-231
Published online on: 01 July 2010

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Article

Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents

Kazutaka Koto, Hiroaki Murata, Shinya Kimura, Naoyuki Horie, Takaaki Matsui, Yasunori Nishigaki, Kazuteru Ryu, Tomoya Sakabe, Megumi Itoi, Eishi Ashihara, Taira Maekawa, Shinji Fushiki, Toshikazu Kubo
Pages: 233-239
Published online on: 01 July 2010

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Article

Down-regulated expression of SERPIN genes located on chromosome 18q21 in oral squamous cell carcinomas

Masashi Shiiba, Hitomi Nomura, Keiji Shinozuka, Kengo Saito, Yukinao Kouzu, Atsushi Kasamatsu, Yosuke Sakamoto, Akiyuki Murano, Kanae Ono, Katsunori Ogawara, Katsuhiro Uzawa, Hideki Tanzawa
Pages: 241-249
Published online on: 01 July 2010

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Article

MEK1 and MEK2 isoforms regulate distinct functions in pancreatic cancer cells

Lei Zhou, Xiaodong Tan, Hidenobu Kamohara, Wei Wang, Baosheng Wang, Jingang Liu, Hiroshi Egami, Hideo Baba, Xianwei Dai
Pages: 251-255
Published online on: 01 July 2010

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Article

Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk

Weimin Gao, Marjorie Romkes, Shilong Zhong, Tomoko Nukui, Raj A. Persad, Patrick J.B. Smith, Robert Branch, Phouthone Keohavong
Pages: 257-262
Published online on: 01 July 2010

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Article

Identification of a 17-protein signature in the serum of lung cancer patients

Roman T. Sreseli, Harald Binder, Madeleine Kuhn, Werner Digel, Hendrik Veelken, Wulf Sienel, Bernward Passlick, Martin Schumacher, Uwe M. Martens, Stefan Zimmermann
Pages: 263-270
Published online on: 01 July 2010

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Article

Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C

Dong-Oh Moon, Mun-Ock Kim, Taek-Jeong Nam, Se-Kwon Kim, Yung Hyun Choi, Gi-Young Kim
Pages: 271-276
Published online on: 01 July 2010

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Article

Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen-activated protein kinase-dependent matrix metalloproteinase-9 expression

Hyo-Jeong Noh, Eon-Gi Sung, Joo-Young Kim, Tae-Jin Lee, In-Hwan Song
Pages: 277-283
Published online on: 01 July 2010

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Article

Role of CDK8 and β-catenin in colorectal adenocarcinoma

Jong-Og Seo, Song Iy Han, Sung-Chul Lim
Pages: 285-291
Published online on: 01 July 2010

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Journal Cover
July-2026 Volume 56 Issue 1

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Journal Metrics

Impact Factor: 3.9

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Review

Advances in Kruppel‑like factor 5 as a transcription factor and its role in gynecological tumors (Review)

Shuqi Zhang, Ping Li, Lixia Zhu
Article Number: 139
Published online on: 28 May 2026

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Review Open Access

Ferroptosis in colorectal cancer: Molecular mechanisms and regulatory crosstalk with therapeutic prospects (Review)

Mingxing Wu, Mingrong Zhang
Article Number: 138
Published online on: 27 May 2026

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Correction Open Access

[Corrigendum] 17‑AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA‑MB‑231 breast cancer cells

Yu Zuo, Heng Xu, Zhifeng Chen, Fengmin Xiong, Bei Zhang, Kaixian Chen, Hualiang Jiang, Cheng Luo, Hao Zhang
Article Number: 137
Published online on: 27 May 2026

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Targeting lung cancer with tanshinones: Current mechanistic evidence and emerging opportunities (Review)

Zhengqi Guo, Xiaoci Li, Pengyu Suo, Zhanyu Lin, Ruixin Liu, Chenyu Chi
Article Number: 136
Published online on: 26 May 2026

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Review Open Access

Immune network remodeling driven by ferroptosis: Bidirectional interaction mechanisms among multiple immune cells in the lung cancer immune microenvironment (Review)

Fei Qu, Jiale Tong, Weiwei Qian, Qian He
Article Number: 135
Published online on: 26 May 2026

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Correction Open Access

[Corrigendum] Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression

Lei Zhu, Xiao-Xia Li, Liang Shi, Jing Wu, Jia-Yi Qian, Tian-Song Xia, Wen-Bin Zhou, Xi Sun, Xu-Jie Zhou, Ji-Fu Wei, Qiang Ding
Article Number: 134
Published online on: 20 May 2026

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Review Open Access

Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review)

Yuanbo Xu, Weili Wang, Yating Zhang, Yinqiu Fan, Wanying Dong, Jun Yang
Article Number: 133
Published online on: 20 May 2026

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Retraction Open Access

[Retracted] Hsp90 inhibitor 17‑AAG inhibits stem cell‑like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway

Xiong Shu, Huiqi Liu, Rui Zhen, Yongsheng Jie, Lei Chen, Hui Qi, Chao Wang, Renxian Wang, Dafu Chen, Yuliang Ran
Article Number: 132
Published online on: 18 May 2026

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Article Open Access

Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway

Huili Feng, Lixin He, Talha Umar, Haipeng Wang, Yanling Gao, Gongyi Chen, Panfeng Sun, Ling Yin, Wenbin Zhao, Huifang Lu, Ganzhen Deng, Changwei Qiu
Article Number: 131
Published online on: 14 May 2026

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Correction Open Access

[Corrigendum] ENO2 affects the EMT process of renal cell carcinoma and participates in the regulation of the immune micro­environment

Wei-Jie Chen, Wei Yang, Min Gong, Yi He, Da Xu, Jia-Xin Chen, Wen-Jin Chen, Wen-Yan Li, Yu-Qi Wang, Ke-Qin Dong, Xu Song, Xiu-Wu Pan, Xin-Gang Cui
Article Number: 130
Published online on: 13 May 2026

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Article Open Access

SRRT promotes prostate cancer progression and serves as a prognostic biomarker through STAT3 pathway activation

Lingxiang Lu, Ke Wu, Zhenfan Wang, Ruoxi Yang, Kai Li, Shuai Guo, Fei Wang, Zheng Ma
Article Number: 129
Published online on: 13 May 2026

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Retraction Open Access

[Retracted] Hsp72 controls bortezomib‑induced HepG2 cell death via interaction with pro‑apoptotic factors 

Giuseppe Calvaruso, Michela Giuliano, Patrizia Portanova, Ornella Pellerito, Renza Vento, Giovanni Tesoriere
Article Number: 128
Published online on: 11 May 2026

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Article Open Access

Effect of the miR‑26a/b‑5p‑STAT3‑YKL‑40 regulatory axis on proliferation, migration, and invasion of endometrial cancer cells

Xinzhao Sun, Shanshan Lin, Xueyan Zhong, Yanlu Luo, Jiahuang Yang, Jiangtao Fan
Article Number: 127
Published online on: 08 May 2026

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Review Open Access

Cancer signaling networks in tumor progression and drug resistance: Crosstalk, adaptive reprogramming and therapeutic targeting (Review)

Hongyan Li, Shiyuan Song, Linlin Wang, Qiang Liu
Article Number: 126
Published online on: 08 May 2026

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Article Open Access

A novel regulatory role of microRNA‑5590‑3p in hepatocellular carcinoma via the HOXB2/MYC axis

Bin Li, Lin Zhou
Article Number: 125
Published online on: 07 May 2026

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Retraction Open Access

[Retracted] SHIP1 is targeted by miR‑155 in acute myeloid leukemia

Hua Xue, Luo-Ming Hua, Ming Guo, Jian-Min Luo
Article Number: 124
Published online on: 05 May 2026

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Review Open Access

Chronic stress and cancer progression through neuro‑endocrine‑immune networks (Review)

Zhangxiang Zhu, Xiaohu Zhang, Jing Yan, Mingquan Wang, Yang Lv, Wuqiong Zhang, Hui Guo, Aimei Zheng
Article Number: 123
Published online on: 04 May 2026

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Retraction Open Access

[Retracted] PTEN enhances G2/M arrest in etoposide‑treated MCF‑7 cells through activation of the ATM pathway

Ruopeng Zhang, Li Zhu, Lirong Zhang, Anli Xu, Zhengwei Li, Yijuan Xu, Pei He, Maoqing Wu, Fengxiang Wei, Chenhong Wang
Article Number: 122
Published online on: 29 April 2026

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Journal Cover
August-2026 Volume 56 Issue 2

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Journal Metrics

Impact Factor: 3.9

CiteScore: 7.7

CiteScore Rank: Q1: #76/428 Oncology

Source Normalized Impact per Paper (SNIP): 0.786

SCImago Journal Rank (SJR): 0.915

Article Open Access

A fibroblast activation protein degrader enhances cisplatin sensitivity in non‑small cell lung cancer

Yong Zhou, Ranhua Li, Xiaobo Chen, Cheng Zhang, Yanan Bao, Yue Cui, Xinghe Tong, Ting Xia, Xudong Yang, Jiqing Yang, Xiaochuan Yin
Article Number: 145
Published online on: 10 June 2026

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Review Open Access

Sterol regulatory element‑binding proteins: Master regulators of lipid metabolic reprogramming in cancer and emerging therapeutic targets (Review)

Qing Liu, Rui Wang, Zhenbo Li, Yihan Liu, Lei Wu, Yuqin Zhao, Jing Yang
Article Number: 144
Published online on: 04 June 2026

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Review Open Access

Dual targeting of mitochondrial metabolism and Rho GTPase signaling to suppress cancer metastasis (Review)

Angelina Daher, Zahraa Assi, Amjad Kanaan, Ahmad Al Khatib, Mirvat El Sibai
Article Number: 143
Published online on: 03 June 2026

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Review Open Access

Targeting colorectal cancer and T‑cell metabolism for the treatment of colorectal cancer (Review)

Qiangzong Yu, Pengbo Luan, Jingru Liang, Lixin Wang
Article Number: 142
Published online on: 02 June 2026

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Expression of Concern Open Access

[Expression of Concern] Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells

Wangdi Liao, Guohua Li, Yu You, Hongping Wan, Qiong Wu, Chongwen Wang, Nonghua Lv
Article Number: 141
Published online on: 02 June 2026

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Article Open Access

Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer

Kunkun Han, Qianyun Zhang, Shengnan Gao, Jigang Zhang, Xiao Mei, Fei Li, Xin Xu, Shu Li, Guodong Chen
Article Number: 140
Published online on: 29 May 2026

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