Open Access

Fas‑670A>G polymorphism is not associated with an increased risk of acute myeloid leukemia development

  • Authors:
    • Ying Huang
    • Donghong Deng
    • Hongying Li
    • Qiang Xiao
    • Lulu Huang
    • Bing Zhang
    • Fanghui Ye
    • Bingbing Ye
    • Zengnan Mo
    • Xiaobo Yang
    • Zhenfang Liu
  • View Affiliations

  • Published online on: December 31, 2015     https://doi.org/10.3892/br.2015.564
  • Pages: 153-160
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The association between the increased risk of acute myeloid leukemia (AML) and Fas promoter polymorphisms has been reported previously; however, the results are inconclusive. The present study performed one case‑control study to investigate the association, and a total of 98 AML patients and 2,014 healthy controls were genotyped. The data showed that the distribution of Fas‑670AA, GA and GG genotypes among the AML patients were not significantly different from those of the healthy controls, all P>0.05. Following this a sub‑study was conducted to analyze individuals who neither smoked nor drank. The results demonstrated that there was still no significant association between the Fas‑670 polymorphism and risk of AML development, all P>0.05. Furthermore, in order to address a more accurate estimation of the association, a meta‑analysis was conducted. Data were systematically collected from the Pubmed, EMBASE and the Wanfang Library. A total of 3 studies were included in this meta‑analysis, which contained 1,144 AML cases and 3,806 controls. No significant association was detected between the Fas‑670A>G polymorphism and AML risk [GA+GG vs. AA: odds ratio (OR) 0.93; 95% confidence interval (CI), 0.79‑1.09; GG vs. AA: OR, 1.01; 95% CI, 0.82‑1.24; GA vs. AA: OR, 1.12; 95% CI, 0.94‑1.32; GG vs. AA+GA: OR, 0.94; 95% CI, 0.79‑1.12; G vs. A: OR, 1.01; 95% CI, 0.91‑1.12; all P>0.05). The analysis clearly indicated that there was no significant connection between the Fas‑670A>G polymorphism and the increased risk of AML.
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February-2016
Volume 4 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Copy and paste a formatted citation
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Spandidos Publications style
Huang Y, Deng D, Li H, Xiao Q, Huang L, Zhang B, Ye F, Ye B, Mo Z, Yang X, Yang X, et al: Fas‑670A>G polymorphism is not associated with an increased risk of acute myeloid leukemia development. Biomed Rep 4: 153-160, 2016
APA
Huang, Y., Deng, D., Li, H., Xiao, Q., Huang, L., Zhang, B. ... Liu, Z. (2016). Fas‑670A>G polymorphism is not associated with an increased risk of acute myeloid leukemia development. Biomedical Reports, 4, 153-160. https://doi.org/10.3892/br.2015.564
MLA
Huang, Y., Deng, D., Li, H., Xiao, Q., Huang, L., Zhang, B., Ye, F., Ye, B., Mo, Z., Yang, X., Liu, Z."Fas‑670A>G polymorphism is not associated with an increased risk of acute myeloid leukemia development". Biomedical Reports 4.2 (2016): 153-160.
Chicago
Huang, Y., Deng, D., Li, H., Xiao, Q., Huang, L., Zhang, B., Ye, F., Ye, B., Mo, Z., Yang, X., Liu, Z."Fas‑670A>G polymorphism is not associated with an increased risk of acute myeloid leukemia development". Biomedical Reports 4, no. 2 (2016): 153-160. https://doi.org/10.3892/br.2015.564