The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease

  • Authors:
    • Qianlin Zhang
    • Xiaoping Du
    • Yuping Xu
    • Lei Dang
    • Li Xiang
    • Jiewen Zhang
  • View Affiliations

  • Published online on: March 14, 2013     https://doi.org/10.3892/etm.2013.1006
  • Pages: 1528-1530
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Abstract

The present study examined the effects of Gouqi (Lycium barbarum) on the learning and memory abilities of an APP/PS1 double transgenic mouse model of Alzheimer's disease. We employed a Morris water maze to examine the spatial memory in this mice line with or without Gouqi extracts treatment. We identified that 2 weeks of oral administration of Gouqi extracts at 10 mg/kg improved the performance of the APP/PS1 mice in the learning and the memory retrieval phases of the Morris maze. In correlation with this, the levels of Aβ(1-42) in hippocampal tissue were reduced by the Gouqi treatment. We conclude that pharmacological treatment with Gouqi extracts is beneficial at the later stages of Alzheimer's disease.
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May 2013
Volume 5 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang Q, Du X, Xu Y, Dang L, Xiang L and Zhang J: The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease. Exp Ther Med 5: 1528-1530, 2013.
APA
Zhang, Q., Du, X., Xu, Y., Dang, L., Xiang, L., & Zhang, J. (2013). The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease. Experimental and Therapeutic Medicine, 5, 1528-1530. https://doi.org/10.3892/etm.2013.1006
MLA
Zhang, Q., Du, X., Xu, Y., Dang, L., Xiang, L., Zhang, J."The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease". Experimental and Therapeutic Medicine 5.5 (2013): 1528-1530.
Chicago
Zhang, Q., Du, X., Xu, Y., Dang, L., Xiang, L., Zhang, J."The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer's disease". Experimental and Therapeutic Medicine 5, no. 5 (2013): 1528-1530. https://doi.org/10.3892/etm.2013.1006