Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST‑segment elevation myocardial infarction

  • Authors:
    • Huijuan Yong
    • Xin Wang
    • Lin Mi
    • Lijun Guo
    • Wei Gao
    • Yongzhen Zhang
    • Ming Cui
  • View Affiliations

  • Published online on: November 28, 2013     https://doi.org/10.3892/etm.2013.1432
  • Pages: 316-322
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Abstract

Previous studies have demonstrated the beneficial effect of statin loading prior to elective and early percutaneous coronary intervention (PCI), in which the ‘pleiotropic effects’ of statins may contribute to these clinical benefits. The aim of the present study was to examine the potential effects of atorvastatin loading prior to primary PCI on coronary endothelial function and inflammatory factors in patients with acute ST‑segment elevation myocardial infarction (STEMI). A total of 60 patients with STEMI were randomized into three groups: Loading dose (80 mg atorvastatin prior to PCI; n=20), regular dose (20 mg atorvastatin prior to PCI; n=20) and control (without atorvastatin prior to PCI; n=20). The plasma samples were collected prior to, and immediately, 6 and 24 h after PCI in all the patients. The plasma concentrations of endothelial nitric oxide synthase (eNOS), nitric oxide (NO), interleukin‑6 (IL‑6), tumor necrosis factor‑α (TNF‑α) and intercellular adhesion molecule‑1 (ICAM‑1) were examined using ELISA. The plasma eNOS levels immediately and 24 h after PCI were significantly higher in the regular dose group compared with the other groups. However, there were no significant differences in the plasma eNOS concentration prior to and 6 h after PCI, or in the plasma NO concentration at any of the time‑points among the three groups. The plasma IL‑6 levels prior to PCI were significantly lower in the loading dose group compared with the other groups; however, there were no significant differences in the plasma concentration of IL‑6 following PCI or in the concentrations of TNF‑α and ICAM‑1 at any of the time‑points among the three groups. In conclusion, atorvastatin loading in patients with STEMI undergoing primary PCI may not have protective effects on endothelial function and the inflammatory reaction.
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2014-February
Volume 7 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yong H, Wang X, Mi L, Guo L, Gao W, Zhang Y and Cui M: Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST‑segment elevation myocardial infarction. Exp Ther Med 7: 316-322, 2014.
APA
Yong, H., Wang, X., Mi, L., Guo, L., Gao, W., Zhang, Y., & Cui, M. (2014). Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST‑segment elevation myocardial infarction. Experimental and Therapeutic Medicine, 7, 316-322. https://doi.org/10.3892/etm.2013.1432
MLA
Yong, H., Wang, X., Mi, L., Guo, L., Gao, W., Zhang, Y., Cui, M."Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST‑segment elevation myocardial infarction". Experimental and Therapeutic Medicine 7.2 (2014): 316-322.
Chicago
Yong, H., Wang, X., Mi, L., Guo, L., Gao, W., Zhang, Y., Cui, M."Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST‑segment elevation myocardial infarction". Experimental and Therapeutic Medicine 7, no. 2 (2014): 316-322. https://doi.org/10.3892/etm.2013.1432