Salvianolic acid B prevents steroid-induced osteonecrosis of the femoral head via PPARγ expression in rats

  • Authors:
    • Shuangqing Li
    • Juan Wang
  • View Affiliations

  • Published online on: December 28, 2016     https://doi.org/10.3892/etm.2016.4008
  • Pages: 651-656
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Salvianolic acid B (Sal B) is a water-soluble phenolic compound derived from Salvia Miltiorrhiza. Recent studies show Sal B has a clear function of anti-cerebral ischemia injury, which is closely related to antioxidation, free radical scavenging, neuroprotection and the blood brain barrier. The aim of the present study was to verify whether Sal B prevents steroid‑induced osteonecrosis of the femoral head and to investigate its underlying pharmacological mechanisms. Steroid‑induced osteonecrosis rat models were established to evaluate the effects of Sal B on osteonecrotic changes and repair processes. The use of Sal B improved steroid‑induced histopathological scores and inhibited osteoclast differentiation in rats. Notably, Sal B induced bone marrow‑derived mesenchymal stem cells into osteogenesis. Moreover, Sal B treatment suppressed peroxisome proliferator-activated receptor (PPAR)γ and AP2 protein expression levels and increased runt-related transcription factor 2 and Collagen I protein expression levels in steroid‑induced rats. osteocalcin and alkaline phosphatase content in steroid‑induced rats was enhanced by treatment with Sal B. These results suggest that Sal B prevents steroid‑induced osteonecrosis of the femoral head via PPARγ expression in rats. The present pilot study provides a brief insight into the effect of Sal B on steroid‑induced osteonecrosis.

Related Articles

Journal Cover

February-2017
Volume 13 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li S and Wang J: Salvianolic acid B prevents steroid-induced osteonecrosis of the femoral head via PPARγ expression in rats. Exp Ther Med 13: 651-656, 2017.
APA
Li, S., & Wang, J. (2017). Salvianolic acid B prevents steroid-induced osteonecrosis of the femoral head via PPARγ expression in rats. Experimental and Therapeutic Medicine, 13, 651-656. https://doi.org/10.3892/etm.2016.4008
MLA
Li, S., Wang, J."Salvianolic acid B prevents steroid-induced osteonecrosis of the femoral head via PPARγ expression in rats". Experimental and Therapeutic Medicine 13.2 (2017): 651-656.
Chicago
Li, S., Wang, J."Salvianolic acid B prevents steroid-induced osteonecrosis of the femoral head via PPARγ expression in rats". Experimental and Therapeutic Medicine 13, no. 2 (2017): 651-656. https://doi.org/10.3892/etm.2016.4008