Open Access

TEG in the monitoring of coagulation changes in patients with sepsis and the clinical significance

  • Authors:
    • Wenyan Zhou
    • Wenjie Zhou
    • Jijia Bai
    • Shenmao Ma
    • Qinfu Liu
    • Xigang Ma
  • View Affiliations

  • Published online on: March 5, 2019     https://doi.org/10.3892/etm.2019.7342
  • Pages: 3373-3382
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Application values of thromboelastography (TEG) in dynamic monitoring of coagulation parameters of sepsis patients were investigated. Eighty-one patients with sepsis who were admitted to the ICU department of the General Hospital of Ningxia Medical University from April 1, 2015 to December 31, 2015 were collected. Clinical data of the patients were collected. Data were compared using 5 grouping methods: i) the 81 patients were divided into the sepsis group (n=45) and sepsis shock group (n=36); ii) patients were divided into two groups: group A (APACHE II score ≤13, n=51); group B (APACHE II score >13, n=30); iii) according to Disseminated Intravascular Coagulation Diagnosis Integral System (CDSS), patients were divided into non-disseminated intravascular coagulation (DIC) group (CDSS <7 points) and DIC group (CDSS ≥7 points); TEG indexes were compared between the two groups; iv) correlation between TEG indexes and Sequential Organ Failure Assessment (SOFA) scores was analyzed; v) patients were divided into survival group and non-survival group and correlations between TEG indicators and prognosis were analyzed. At 6 h after ICU entry, compared with sepsis group, R value and K time were significantly increased, LY30 was also increased, while MA value, coagulation index (CI), and α angle were significantly decreased in the septic shock group (P<0.05). At 6 h after ICU entry, compared with sepsis group, R value and K time were significantly increased, while MA value, CI, and α angle were significantly decreased in the septic shock group (P<0.05). Compared with the non-DIC group, the DIC group had prolonged K time, decreased α angle, increased R value, and decreased CI and MA value (P<0.05). With increase of SOFA scores, R value and K value increased significantly, and α angle, MA value, and CI decreased significantly (P<0.05). According to TEG, platelet function and fibrinogen function of DIC patients were significantly reduced, and the body showed hypocoagulability.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou W, Zhou W, Bai J, Ma S, Liu Q and Ma X: TEG in the monitoring of coagulation changes in patients with sepsis and the clinical significance. Exp Ther Med 17: 3373-3382, 2019.
APA
Zhou, W., Zhou, W., Bai, J., Ma, S., Liu, Q., & Ma, X. (2019). TEG in the monitoring of coagulation changes in patients with sepsis and the clinical significance. Experimental and Therapeutic Medicine, 17, 3373-3382. https://doi.org/10.3892/etm.2019.7342
MLA
Zhou, W., Zhou, W., Bai, J., Ma, S., Liu, Q., Ma, X."TEG in the monitoring of coagulation changes in patients with sepsis and the clinical significance". Experimental and Therapeutic Medicine 17.5 (2019): 3373-3382.
Chicago
Zhou, W., Zhou, W., Bai, J., Ma, S., Liu, Q., Ma, X."TEG in the monitoring of coagulation changes in patients with sepsis and the clinical significance". Experimental and Therapeutic Medicine 17, no. 5 (2019): 3373-3382. https://doi.org/10.3892/etm.2019.7342