Open Access

Knockdown of lncRNA CCEPR suppresses colorectal cancer progression

  • Authors:
    • Yuxia Duan
    • Zhixue Fang
    • Zeya Shi
    • Ling Zhang
  • View Affiliations

  • Published online on: August 26, 2019     https://doi.org/10.3892/etm.2019.7942
  • Pages: 3534-3542
  • Copyright: © Duan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non‑coding RNAs (lncRNAs) serve important roles in colorectal cancer. The aim of the present study was to investigate the expression and role of cervical carcinoma expressed PCNA regulatory (CCEPR) lncRNA in colorectal cancer progression. The results demonstrated that CCEPR expression was significantly higher in colorectal cancer tissues when compared with paired adjacent normal tissues. In addition, CCEPR expression was significantly higher in patients with advanced colorectal cancer (stage III/IV) than those with early‑stage colorectal cancer (stage I/II). High CCEPR expression was significantly associated with poor differentiation, advanced clinical stage, positive lymph node metastasis and distant metastasis. Of particular note, patients with colorectal cancer exhibiting high CCEPR expression levels had shorter survival rates when compared with patients with low CCEPR expression. In vitro experiments demonstrated that the expression of CCEPR was increased in colorectal cancer cell lines when compared with a normal colon cell line. Knockdown of CCEPR significantly inhibited colorectal cancer cell proliferation, colony formation and cell cycle progression, as well as cell migration and invasion. Finally, silencing of CCEPR downregulated matrix metalloproteinase (MMP)‑2 and MMP‑9 expression and suppressed epithelial‑mesenchymal transition in colorectal cancer cells. In conclusion, the results of the present study suggest that CCEPR may exert an oncogenic role in colorectal cancer, and CCEPR may be a promising molecular target for colorectal cancer treatment.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Duan Y, Fang Z, Shi Z and Zhang L: Knockdown of lncRNA CCEPR suppresses colorectal cancer progression. Exp Ther Med 18: 3534-3542, 2019.
APA
Duan, Y., Fang, Z., Shi, Z., & Zhang, L. (2019). Knockdown of lncRNA CCEPR suppresses colorectal cancer progression. Experimental and Therapeutic Medicine, 18, 3534-3542. https://doi.org/10.3892/etm.2019.7942
MLA
Duan, Y., Fang, Z., Shi, Z., Zhang, L."Knockdown of lncRNA CCEPR suppresses colorectal cancer progression". Experimental and Therapeutic Medicine 18.5 (2019): 3534-3542.
Chicago
Duan, Y., Fang, Z., Shi, Z., Zhang, L."Knockdown of lncRNA CCEPR suppresses colorectal cancer progression". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3534-3542. https://doi.org/10.3892/etm.2019.7942