Open Access

Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells

  • Authors:
    • Linna Zhang
    • Huimei Cao
    • Hong Tao
    • Jijuan Yang
    • Wei Gong
    • Qikuan Hu
  • View Affiliations

  • Published online on: May 2, 2021     https://doi.org/10.3892/etm.2021.10128
  • Article Number: 696
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, a model of glioma stem cells (GSCs) was established and combined with molecular targeting drugs in order to observe its inhibitory effect on the proliferation and biological characteristics of GSCs, with the aim of providing a potential target for the treatment of glioma. On the basis of a relatively classical induction strategy with neuron induction medium, a large number of GSC‑like cells in good condition and globular growth were amplified in vitro, which had the potential to differentiate into neurons, oligodendrocytes and astrocytes/glioma cells. It was observed that the interference with dynamin‑related protein 1 expression using Mdivi‑1, a mitochondrial mitotic inhibitor, at the optimal concentration, decreased the expression level of stem cell‑associated genes, inhibited proliferation and promoted apoptosis in GSCs. The present study provided an experimental basis for a novel strategy of cancer treatment with tumor stem cells as the target.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang L, Cao H, Tao H, Yang J, Gong W and Hu Q: Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells. Exp Ther Med 22: 696, 2021
APA
Zhang, L., Cao, H., Tao, H., Yang, J., Gong, W., & Hu, Q. (2021). Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells. Experimental and Therapeutic Medicine, 22, 696. https://doi.org/10.3892/etm.2021.10128
MLA
Zhang, L., Cao, H., Tao, H., Yang, J., Gong, W., Hu, Q."Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells". Experimental and Therapeutic Medicine 22.1 (2021): 696.
Chicago
Zhang, L., Cao, H., Tao, H., Yang, J., Gong, W., Hu, Q."Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells". Experimental and Therapeutic Medicine 22, no. 1 (2021): 696. https://doi.org/10.3892/etm.2021.10128