REM sleep behaviour disorder in Parkinson's disease (Review)

  • Authors:
    • Ștefania Diaconu
    • Oana Falup‑Pecurariu
    • Diana Țînț
    • Cristian Falup‑Pecurariu
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  • Published online on: May 28, 2021     https://doi.org/10.3892/etm.2021.10244
  • Article Number: 812
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Abstract

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia defined by simple or complex abnormal movements occurring in REM state, instead of the physiological muscular atonia. RBD may be idiopathic, or secondary as in the case of Parkinson's disease (PD). Several studies have confirmed that idiopathic RBD may precede with several years the onset of the specific motor characteristics of PD. The high prevalence of RBD in PD (19‑70%) may be explained by several common pathophysiological pathways, mainly related to the dopaminergic cell loss. RBD is also associated with several comorbidities, including cognitive impairment, hallucinations, dysautonomia, or daytime sleepiness. The gold standard investigation for the diagnosis and assessment of RBD is video polysomnography, but in clinical practice, the use of clinical scales and questionnaires is reasonable for the screening of this complex parasomnia. Management options include ensuring a safe environment for the patient and pharmacological treatment, incuding clonazepam, melatonin or certain antiparkinsonian drugs.
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August-2021
Volume 22 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Diaconu Ș, Falup‑Pecurariu O, Țînț D and Falup‑Pecurariu C: REM sleep behaviour disorder in Parkinson's disease (Review). Exp Ther Med 22: 812, 2021
APA
Diaconu, Ș., Falup‑Pecurariu, O., Țînț, D., & Falup‑Pecurariu, C. (2021). REM sleep behaviour disorder in Parkinson's disease (Review). Experimental and Therapeutic Medicine, 22, 812. https://doi.org/10.3892/etm.2021.10244
MLA
Diaconu, Ș., Falup‑Pecurariu, O., Țînț, D., Falup‑Pecurariu, C."REM sleep behaviour disorder in Parkinson's disease (Review)". Experimental and Therapeutic Medicine 22.2 (2021): 812.
Chicago
Diaconu, Ș., Falup‑Pecurariu, O., Țînț, D., Falup‑Pecurariu, C."REM sleep behaviour disorder in Parkinson's disease (Review)". Experimental and Therapeutic Medicine 22, no. 2 (2021): 812. https://doi.org/10.3892/etm.2021.10244