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Long non‑coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR‑425‑5p expression

  • Authors:
    • Yating Fu
    • Ying Liu
    • Aheli Nasiroula
    • Qichao Wang
    • Xinhua Cao
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Urumqi Stomatological Hospital, Urumqi, Xinjiang Uygur Autonomous Region 830011, P.R. China, Department of General Special Requirements, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830011, P.R. China, Department of Oncology II, Dalian Fifth People's Hospital, Dalian, Liaoning 116021, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 246
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    Published online on: January 28, 2022
       https://doi.org/10.3892/etm.2022.11171
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Abstract

Long non‑coding RNA (lncRNA) HLA complex group 22 (HCG22) is known to be involved in the occurrence and development of cancer; however, its role in oral squamous cell carcinoma (OSCC) remains unclear. Therefore, the main aim of the present study was to investigate the role and mechanisms of action of lncRNA HCG22 in OSCC cells. The expression levels of lncRNA HCG22 and microRNA (miR)‑425‑5p in OSCC cells were assessed using reverse transcription-quantitative PCR analysis. Cell proliferation was detected using Cell Counting Kit‑8 and colony formation assays. In addition, the expression levels of cell proliferation‑related proteins, p27, cyclin E and cyclin‑dependent kinase 2, were detected by western blot analysis. The cell invasive ability was detected by Transwell assay, while the cell migratory ability was detected via a wound healing assay. The expression levels of the invasion‑ and migration‑related proteins, MMP2 and MMP9, were measured by western blot analysis. The targeted association between lncRNA HCG22 and miR‑425‑5p was verified by RNA immunoprecipitation and dual‑luciferase reporter assays. The results revealed that lncRNA LCG22 was expressed at low levels, while miR‑425‑5p was highly expressed in OSCC cell lines, based on bioinformatics analysis. The overexpression of lncRNA HCG22 inhibited the proliferation, invasion and migration of OSCC cells. Moreover, lncRNA HCG22 and miR‑425‑5p were found to have a direct targeted association, and lncRNA HCG22 inhibited cell proliferation, invasion and migration by targeting miR‑425‑5p. Collectively, the findings of the present study demonstrated that lncRNA HCG22 may inhibit the proliferation, invasion and migration of OSCC cells by downregulating miR‑425‑5p expression.
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1 

Sun LP, Xu K, Cui J, Yuan DY, Zou B, Li J, Liu JL, Li KY, Meng Z and Zhang B: Cancerassociated fibroblastderived exosomal miR3825p promotes the migration and invasion of oral squamous cell carcinoma. Oncol Rep. 42:1319–1328. 2019.PubMed/NCBI View Article : Google Scholar

2 

Arimoto S, Hasegawa T, Takeda D, Saito I, Amano R, Akashi M and Komori T: Lymphangiogenesis and lymph node metastasis in oral squamous cell carcinoma. Anticancer Res. 38:6157–6162. 2018.PubMed/NCBI View Article : Google Scholar

3 

Panarese I, Aquino G, Ronchi A, Longo F, Montella M, Cozzolino I, Roccuzzo G, Colella G, Caraglia M and Franco R: Oral and oropharyngeal squamous cell carcinoma: Prognostic and predictive parameters in the etiopathogenetic route. Expert Rev Anticancer Ther. 19:105–119. 2019.PubMed/NCBI View Article : Google Scholar

4 

da Silva SD, Hier M, Mlynarek A, Kowalski LP and Alaoui-Jamali MA: Recurrent oral cancer: Current and emerging therapeutic approaches. Front Pharmacol. 3(149)2012.PubMed/NCBI View Article : Google Scholar

5 

Rogers SN, Brown JS, Woolgar JA, Lowe D, Magennis P, Shaw RJ, Sutton D, Errington D and Vaughan D: Survival following primary surgery for oral cancer. Oral Oncol. 45:201–211. 2009.PubMed/NCBI View Article : Google Scholar

6 

Chi AC, Day TA and Neville BW: Oral cavity and oropharyngeal squamous cell carcinoma-an update. CA Cancer J Clin. 65:401–421. 2015.PubMed/NCBI View Article : Google Scholar

7 

Yao C, Chang EI and Lai SY: Contemporary approach to locally advanced oral cavity squamous cell carcinoma. Curr Oncol Rep. 21(99)2019.PubMed/NCBI View Article : Google Scholar

8 

Quinn JJ and Chang HY: Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 17:47–62. 2016.PubMed/NCBI View Article : Google Scholar

9 

Chi Y, Wang D, Wang J, Yu W and Yang J: Long non-coding RNA in the pathogenesis of cancers. Cells. 8(1015)2019.PubMed/NCBI View Article : Google Scholar

10 

Sanchez Calle A, Kawamura Y, Yamamoto Y, Takeshita F and Ochiya T: Emerging roles of long non-coding RNA in cancer. Cancer Sci. 109:2093–2100. 2018.PubMed/NCBI View Article : Google Scholar

11 

Xu D, Chen Y, Yuan C, Zhang S and Peng W: Long non-coding RNA LINC00662 promotes proliferation and migration in oral squamous cell carcinoma. Onco Targets Ther. 12:647–656. 2019.PubMed/NCBI View Article : Google Scholar

12 

Wang X, Liu W, Wang P and Li S: RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma. J Oral Pathol Med. 47:930–937. 2018.PubMed/NCBI View Article : Google Scholar

13 

Wang R, Lu X and Yu R: lncRNA MALAT1 promotes EMT process and cisplatin resistance of oral squamous cell carcinoma via PI3K/AKT/m-TOR signal pathway. OncoTargets Ther. 13:4049–4061. 2020.PubMed/NCBI View Article : Google Scholar

14 

Xiao L, Wang W, Zhao J, Xu H, Li S and Yang X: lncRNA MALAT1 promotes cell proliferation and invasion by regulating the miR101/EZH2 axis in oral squamous cell carcinoma. Onco Lett. 20(164)2020.PubMed/NCBI View Article : Google Scholar

15 

Yatagai Y, Hirota T, Sakamoto T, Yamada H, Masuko H, Kaneko Y, Iijima H, Naito T, Noguchi E, Tamari M, et al: Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations. J Allergy Clin Immunol. 138:281–283.e13. 2016.PubMed/NCBI View Article : Google Scholar

16 

Jeong S, Patel N, Edlund CK, Hartiala J, Hazelett DJ, Itakura T, Wu PC, Avery RL, Davis JL and Flynn HW: Identification of a novel mucin gene HCG22 associated with steroid-induced ocular hypertension. Invest Ophthalmol Vis Sci. 56:2737–2748. 2015.PubMed/NCBI View Article : Google Scholar

17 

Li Y, Shi X, Yang W, Lu Z, Wang P, Chen Z and He J: Transcriptome profiling of lncRNA and co-expression networks in esophageal squamous cell carcinoma by RNA sequencing. Tumour Biol. 37:13091–13100. 2016.PubMed/NCBI View Article : Google Scholar

18 

Guo YZ, Sun HH, Wang XT and Wang MT: Transcriptomic analysis reveals key lncRNAs associated with ribosomal biogenesis and epidermis differentiation in head and neck squamous cell carcinoma. J Zhejiang Univ Sci B. 19:674–688. 2018.PubMed/NCBI View Article : Google Scholar

19 

Xu Y, Chen J, Yang Z and Xu L: Identification of RNA expression profiles in thyroid cancer to construct a competing endogenous RNA (ceRNA) network of mRNAs, long noncoding RNAs (lncRNAs), and microRNAs (miRNAs). Med Sci Monit. 25:1140–1154. 2019.PubMed/NCBI View Article : Google Scholar

20 

Jiang L, Hong L, Yang W, Zhao Y, Tan A and Li Y: Co-expression network analysis of the lncRNAs and mRNAs associated with cervical cancer progression. Arch Med Sci. 15:754–764. 2019.PubMed/NCBI View Article : Google Scholar

21 

Jiang D, Zhang Y, Yang L, Lu W, Mai L, Guo H and Liu X: Long noncoding RNA HCG22 suppresses proliferation and metastasis of bladder cancer cells by regulation of PTBP1. J Cell Physiol. 235:1711–1722. 2020.PubMed/NCBI View Article : Google Scholar

22 

Li X, Xiao X, Chang R and Zhang C: Comprehensive bioinformatics analysis identifies lncRNA HCG22 as a migration inhibitor in esophageal squamous cell carcinoma. J Cell Biochem. 121:468–481. 2020.PubMed/NCBI View Article : Google Scholar

23 

Feng L, Houck JR, Lohavanichbutr P and Chen C: Transcriptome analysis reveals differentially expressed lncRNAs between oral squamous cell carcinoma and healthy oral mucosa. Oncotarget. 8:31521–31531. 2017.PubMed/NCBI View Article : Google Scholar

24 

Nohata N, Abba MC and Gutkind JS: Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection. Oral Oncol. 59:58–66. 2016.PubMed/NCBI View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

26 

Cao C, Zhong Q, Lu L, Huang B, Li J, Meng L and Wei H: Long noncoding RNA MSC-AS1 promotes hepatocellular carcinoma oncogenesis via inducing the expression of phosphoglycerate kinase 1. Cancer Med. 9:5174–5184. 2020.PubMed/NCBI View Article : Google Scholar

27 

Li C, Feng S and Chen L: MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway. Mol Cell Biochem. 476:699–713. 2020.PubMed/NCBI View Article : Google Scholar

28 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006.PubMed/NCBI View Article : Google Scholar

29 

Karreth FA, Reschke M, Ruocco A, Ng C, Chapuy B, Léopold V, Sjoberg M, Keane TM, Verma A, Ala U, et al: The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo. Cell. 161:319–332. 2015.PubMed/NCBI View Article : Google Scholar

30 

Fukumoto I, Hanazawa T, Kinoshita T, Kikkawa N, Koshizuka K, Goto Y, Nishikawa R, Chiyomaru T, Enokida H, Nakagawa M, et al: MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways. Br J Cancer. 112:891–900. 2015.PubMed/NCBI View Article : Google Scholar

31 

Manikandan M, Deva Magendhra Rao AK, Arunkumar G, Manickavasagam M, Rajkumar KS, Rajaraman R and Munirajan AK: Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism. Mol Cancer. 15(28)2016.PubMed/NCBI View Article : Google Scholar

32 

Cristóbal I, Madoz-Gúrpide J, Rojo F and García-Foncillas J: Potential therapeutic value of miR-425-5p in metastatic colorectal cancer. J Cell Mol Med. 20:2213–2214. 2016.PubMed/NCBI View Article : Google Scholar

33 

Sun L, Jiang R, Li J, Wang B, Ma C, Lv Y and Mu N: MicoRNA-425-5p is a potential prognostic biomarker for cervical cancer. Ann Clin Biochem. 54:127–133. 2017.PubMed/NCBI View Article : Google Scholar

34 

Fang F, Song T, Zhang T, Cui Y, Zhang G and Xiong Q: MiR-425-5p promotes invasion and metastasis of hepatocellular carcinoma cells through SCAI-mediated dysregulation of multiple signaling pathways. Oncotarget. 8:31745–31757. 2017.PubMed/NCBI View Article : Google Scholar

35 

Zhang Z, Li Y, Fan L, Zhao Q, Tan B, Li Z and Zang A: microRNA-425-5p is upregulated in human gastric cancer and contributes to invasion and metastasis in vitro and in vivo. Exp Ther Med. 9:1617–1622. 2015.PubMed/NCBI View Article : Google Scholar

36 

Wang J, Li Z, Ge Q, Wu W, Zhu Q, Luo J and Chen L: Characterization of microRNA transcriptome in tumor, adjacent, and normal tissues of lung squamous cell carcinoma. J Thorac Cardiovasc Surg. 149:1404–1414.e4. 2015.PubMed/NCBI View Article : Google Scholar

37 

Summerer I, Niyazi M, Unger K, Pitea A, Zangen V, Hess J, Atkinson MJ, Belka C, Moertl S and Zitzelsberger H: Changes in circulating microRNAs after radiochemotherapy in head and neck cancer patients. Radiat Oncol. 8(296)2013.PubMed/NCBI View Article : Google Scholar

38 

Jiang L, Wang Y, Liu G, Liu H, Zhu F, Ji H and Li B: C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells. Cancer Cell Int. 18(12)2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Fu Y, Liu Y, Nasiroula A, Wang Q and Cao X: Long non‑coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR‑425‑5p expression. Exp Ther Med 23: 246, 2022.
APA
Fu, Y., Liu, Y., Nasiroula, A., Wang, Q., & Cao, X. (2022). Long non‑coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR‑425‑5p expression. Experimental and Therapeutic Medicine, 23, 246. https://doi.org/10.3892/etm.2022.11171
MLA
Fu, Y., Liu, Y., Nasiroula, A., Wang, Q., Cao, X."Long non‑coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR‑425‑5p expression". Experimental and Therapeutic Medicine 23.3 (2022): 246.
Chicago
Fu, Y., Liu, Y., Nasiroula, A., Wang, Q., Cao, X."Long non‑coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR‑425‑5p expression". Experimental and Therapeutic Medicine 23, no. 3 (2022): 246. https://doi.org/10.3892/etm.2022.11171
Copy and paste a formatted citation
x
Spandidos Publications style
Fu Y, Liu Y, Nasiroula A, Wang Q and Cao X: Long non‑coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR‑425‑5p expression. Exp Ther Med 23: 246, 2022.
APA
Fu, Y., Liu, Y., Nasiroula, A., Wang, Q., & Cao, X. (2022). Long non‑coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR‑425‑5p expression. Experimental and Therapeutic Medicine, 23, 246. https://doi.org/10.3892/etm.2022.11171
MLA
Fu, Y., Liu, Y., Nasiroula, A., Wang, Q., Cao, X."Long non‑coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR‑425‑5p expression". Experimental and Therapeutic Medicine 23.3 (2022): 246.
Chicago
Fu, Y., Liu, Y., Nasiroula, A., Wang, Q., Cao, X."Long non‑coding RNA HCG22 inhibits the proliferation, invasion and migration of oral squamous cell carcinoma cells by downregulating miR‑425‑5p expression". Experimental and Therapeutic Medicine 23, no. 3 (2022): 246. https://doi.org/10.3892/etm.2022.11171
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