Prieto-Alhambra D, Judge A, Javaid MK, Cooper C, Diez-Perez A and Arden NK: Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: Influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 73:1659–1664. 2014.PubMed/NCBI View Article : Google Scholar

Busija L, Bridgett L, Williams SR, Osborne RH, Buchbinder R, March L and Fransen M: Osteoarthritis. Best Pract Res Clin Rheumatol. 24:757–768. 2010.PubMed/NCBI View Article : Google Scholar

Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, Kington RS, Lane NE, Nevitt MC, Zhang Y, et al: Osteoarthritis: New insights. Part 1: The disease and its risk factors. Ann Intern Med. 133:635–646. 2000.PubMed/NCBI View Article : Google Scholar

Michael JW, Schlüter-Brust KU and Eysel P: The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee. Dtsch Arztebl Int. 107:152–162. 2010.PubMed/NCBI View Article : Google Scholar

Andriacchi TP, Mündermann A, Smith RL, Alexander EJ, Dyrby CO and Koo S: A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng. 32:447–457. 2004.PubMed/NCBI View Article : Google Scholar

Dawson J, Linsell L, Zondervan K, Rose P, Carr A, Randall T and Fitzpatrick R: Impact of persistent hip or knee pain on overall health status in elderly people: A longitudinal population study. Arthritis Rheum. 53:368–374. 2005.PubMed/NCBI View Article : Google Scholar

Xiang YJ and Dai SM: Prevalence of rheumatic diseases and disability in China. Rheumatol Int. 29:481–490. 2009.PubMed/NCBI View Article : Google Scholar

Tang X, Wang S, Zhan S, Niu J, Tao K, Zhang Y and Lin J: The prevalence of symptomatic knee osteoarthritis in China: Results from the China Health and retirement longitudinal study. Arthritis Rheumatol. 68:648–653. 2016.PubMed/NCBI View Article : Google Scholar

Sarzi-Puttini P, Cimmino MA, Scarpa R, Caporali R, Parazzini F, Zaninelli A, Atzeni F and Canesi B: Osteoarthritis: An overview of the disease and its treatment strategies. Semin Arthritis Rheum. 35:1–10. 2005.PubMed/NCBI View Article : Google Scholar

Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Bennell K, Bierma-Zeinstra SMA, Kraus VB, Lohmander LS, Abbott JH, Bhandari M, et al: OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 27:1578–1589. 2019.PubMed/NCBI View Article : Google Scholar

Brophy RH and Fillingham YA: AAOS Clinical practice guideline summary: Management of osteoarthritis of the Knee (Nonarthroplasty), Third edition. J Am Acad Orthop Surg. 30:e721–e729. 2022.PubMed/NCBI View Article : Google Scholar

Peng H, Ou A, Huang X, Wang C, Wang L, Yu T and Zhang Y and Zhang Y: Osteotomy around the knee: The surgical treatment of osteoarthritis. Orthop Surg. 13:1465–1473. 2021.PubMed/NCBI View Article : Google Scholar

Jang S, Lee K and Ju JH: Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee. Int J Mol Sci. 22(2619)2021.PubMed/NCBI View Article : Google Scholar

Bichsel D, Liechti FD, Schlapbach JM and Wertli MM: Cross-sectional analysis of recommendations for the treatment of hip and knee osteoarthritis in clinical guidelines. Arch Phys Med Rehabil. 103:559–569.e5. 2022.PubMed/NCBI View Article : Google Scholar

Bahar E, Shamarina D, Sergerie Y and Mukherjee P: Descriptive overview of pertussis epidemiology among older adults in Europe during 2010-2020. Infect Dis Ther. 11:1821–1838. 2022.PubMed/NCBI View Article : Google Scholar

Madry H, Kon E, Condello V, Peretti GM, Steinwachs M, Seil R, Berruto M, Engebretsen L, Filardo G and Angele P: Early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 24:1753–1762. 2016.PubMed/NCBI View Article : Google Scholar

Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Guillemin F, Hill CL, et al: The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 73:1323–1330. 2014.PubMed/NCBI View Article : Google Scholar

Woolf AD and Pfleger B: Burden of major musculoskeletal conditions. Bull World Health Organ. 81:646–656. 2003.PubMed/NCBI

Abbassy AA, Trebinjac S and Kotb N: The use of cellular matrix in symptomatic knee osteoarthritis. Bosn J Basic Med Sci. 20:271–274. 2020.PubMed/NCBI View Article : Google Scholar

Zhang Y, Xu L, Nevitt MC, Aliabadi P, Yu W, Qin M, Lui LY and Felson DT: Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: The Beijing Osteoarthritis Study. Arthritis Rheum. 44:2065–2071. 2001.PubMed/NCBI View Article : Google Scholar

(AUS) AOA: Lay summary 2015 annual report hip and knee replacement: Suppliment report, 2015.

Zhou Z, Cui J, Wu S, Geng Z and Su J: Silk fibroin-based biomaterials for cartilage/osteochondral repair. Theranostics. 12:5103–5124. 2022.PubMed/NCBI View Article : Google Scholar

Hiligsmann M, Cooper C, Arden N, Boers M, Branco JC, Luisa Brandi M, Bruyère O, Guillemin F, Hochberg MC, Hunter DJ, et al: Health economics in the field of osteoarthritis: An Expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum. 43:303–313. 2013.PubMed/NCBI View Article : Google Scholar

Arden N and Nevitt MC: Osteoarthritis: Epidemiology. Best Pract Res Clin Rheumatol. 20:3–25. 2006.PubMed/NCBI View Article : Google Scholar

Hunter DJ, Snieder H, March L and Sambrook PN: Genetic contribution to cartilage volume in women: A classical twin study. Rheumatology (Oxford). 42:1495–1500. 2003.PubMed/NCBI View Article : Google Scholar

Barat-Houari M, Sarrabay G, Gatinois V, Fabre A, Dumont B, Genevieve D and Touitou I: Mutation update for COL2A1 gene variants associated with type II collagenopathies. Hum Mutat. 37:7–15. 2016.PubMed/NCBI View Article : Google Scholar

Chapman K and Valdes AM: Genetic factors in OA pathogenesis. Bone. 51:258–264. 2012.PubMed/NCBI View Article : Google Scholar

Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y, Zhao Y and Wang C: Body mass index and susceptibility to knee osteoarthritis: A systematic review and meta-analysis. Joint Bone Spine. 79:291–297. 2012.PubMed/NCBI View Article : Google Scholar

Ji S, Liu L, Li J, Zhao G, Cai Y, Dong Y, Wang J and Wu S: Prevalence and factors associated with knee osteoarthritis among middle-aged and elderly individuals in rural Tianjin: A population-based cross-sectional study. J Orthop Surg Res. 18(266)2023.PubMed/NCBI View Article : Google Scholar

Hunter DJ and Felson DT: Osteoarthritis. BMJ. 332:639–642. 2006.PubMed/NCBI View Article : Google Scholar

Jordan JM, Luta G, Renner JB, Dragomir A, Hochberg MC and Fryer JG: Ethnic differences in self-reported functional status in the rural south: The Johnston County Osteoarthritis Project. Arthritis Care Res. 9:483–491. 1996.PubMed/NCBI View Article : Google Scholar

Srikanth VK, Fryer JL, Zhai G, Winzenberg TM, Hosmer D and Jones G: A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage. 13:769–781. 2005.PubMed/NCBI View Article : Google Scholar

Shu Z, Miao X, Tang T, Zhan P, Zeng L and Jiang Y: The GSK-3β/β-catenin signaling pathway is involved in HMGB1-induced chondrocyte apoptosis and cartilage matrix degradation. Int J Mol Med. 45:769–778. 2020.PubMed/NCBI View Article : Google Scholar

Xu L, Nevitt MC, Zhang Y, Yu W, Alibadi P and Felson DT: High prevalence of knee, but not hip or hand osteoarthritis in Beijing elders: Comparison with data of Caucasian in United States. Zhonghua Yi Xue Za Zhi. 83:1206–1209. 2003.PubMed/NCBI(In Chinese).

Guccione AA, Felson DT, Anderson JJ, Anthony JM, Zhang Y, Wilson PW, Kelly-Hayes M, Wolf PA, Kreger BE and Kannel WB: The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health. 84:351–358. 1994.PubMed/NCBI View Article : Google Scholar

Øiestad BE, Engebretsen L, Storheim K and Risberg MA: Knee osteoarthritis after anterior cruciate ligament injury: A systematic review. Am J Sports Med. 37:1434–1443. 2009.PubMed/NCBI View Article : Google Scholar

Webster KE and Hewett TE: Anterior cruciate ligament injury and knee osteoarthritis: An umbrella systematic review and meta-analysis. Clin J Sport Med. 32:145–152. 2022.PubMed/NCBI View Article : Google Scholar

Xie F, Li SC, Fong KY, Lo NN, Yeo SJ, Yang KY and Thumboo J: What health domains and items are important to patients with knee osteoarthritis? A focus group study in a multiethnic urban Asian population. Osteoarthritis Cartilage. 14:224–230. 2006.PubMed/NCBI View Article : Google Scholar

Stitik TP and Foye PM: The prevalence of knee pain and symptomatic knee osteoarthritis among veteran traumatic amputees and nonamputees. Arch Phys Med Rehabil. 86(1273)2005.PubMed/NCBI View Article : Google Scholar

Wigley RD, Zhang NZ, Zeng QY, Shi CS, Hu DW, Couchman K, Duff IF and Bennett PH: Rheumatic diseases in China: ILAR-China study comparing the prevalence of rheumatic symptoms in northern and southern rural populations. J Rheumatol. 21:1484–1490. 1994.PubMed/NCBI

Palmer KT: Occupational activities and osteoarthritis of the knee. Br Med Bull. 102:147–170. 2012.PubMed/NCBI View Article : Google Scholar

Lau EC, Cooper C, Lam D, Chan VN, Tsang KK and Sham A: Factors associated with osteoarthritis of the hip and knee in Hong Kong Chinese: Obesity, joint injury, and occupational activities. Am J Epidemiol. 152:855–862. 2000.PubMed/NCBI View Article : Google Scholar

Fuller-Thomson E, Stefanyk M and Brennenstuhl S: The robust association between childhood physical abuse and osteoarthritis in adulthood: Findings from a representative community sample. Arthritis Rheum. 61:1554–1562. 2009.PubMed/NCBI View Article : Google Scholar

Rossignol M, Leclerc A, Allaert FA, Rozenberg S, Valat JP, Avouac B, Coste P, Litvak E and Hilliquin P: Primary osteoarthritis of hip, knee, and hand in relation to occupational exposure. Occup Environ Med. 62:772–777. 2005.PubMed/NCBI View Article : Google Scholar

Ni J, Wang P, Yin KJ, Huang JX, Tian T, Cen H, Sui C, Xu Z and Pan HF: Does smoking protect against developing osteoarthritis? Evidence from a genetically informed perspective. Semin Arthritis Rheum. 55(152013)2022.PubMed/NCBI View Article : Google Scholar

Morales-Ivorra I, Romera-Baures M, Roman-Viñas B and Serra-Majem L: Osteoarthritis and the Mediterranean Diet: A systematic review. Nutrients. 10(1030)2018.PubMed/NCBI View Article : Google Scholar

Uryu N, Okada K and Kawakita K: Analgesic effects of indirect moxibustion on an experimental rat model of osteoarthritis in the knee. Acupunct Med. 25:175–183. 2007.PubMed/NCBI View Article : Google Scholar

Torelli SR, Rahal SC, Volpi RS, Sequeira JL and Grassioto IQ: Histopathological evaluation of treatment with chondroitin sulphate for osteoarthritis induced by continuous immobilization in rabbits. J Vet Med A Physiol Pathol Clin Med. 52:45–51. 2005.PubMed/NCBI View Article : Google Scholar

Kim JR, Yoo JJ and Kim HA: Therapeutics in osteoarthritis based on an understanding of its molecular pathogenesis. Int J Mol Sci. 19(674)2018.PubMed/NCBI View Article : Google Scholar

Wojdasiewicz P, Poniatowski ŁA and Szukiewicz D: The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm. 2014(561459)2014.PubMed/NCBI View Article : Google Scholar

Wang Q, Pan X, Wong HH, Wagner CA, Lahey LJ, Robinson WH and Sokolove J: Oral and topical boswellic acid attenuates mouse osteoarthritis. Osteoarthritis Cartilage. 22:128–132. 2014.PubMed/NCBI View Article : Google Scholar

Yoshida A, Morihara T, Matsuda K, Sakamoto H, Arai Y, Kida Y, Kawata M and Kubo T: Immunohistochemical analysis of the effects of estrogen on intraarticular neurogenic inflammation in a rat anterior cruciate ligament transection model of osteoarthritis. Connect Tissue Res. 53:197–206. 2012.PubMed/NCBI View Article : Google Scholar

Sutipornpalangkul W, Morales NP and Harnroongroj T: Free radicals in primary knee osteoarthritis. J Med Assoc Thai. 92 (Suppl 6):S268–S274. 2009.PubMed/NCBI

Guilak F, Nims RJ, Dicks A, Wu CL and Meulenbelt I: Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol. 71-72:40–50. 2018.PubMed/NCBI View Article : Google Scholar

Aurich M, Squires GR, Reiner A, Mollenhauer JA, Kuettner KE, Poole AR and Cole AA: Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints. Arthritis Rheum. 52:112–119. 2005.PubMed/NCBI View Article : Google Scholar

Yao Q, Wu X, Tao C, Gong W, Chen M, Qu M, Zhong Y, He T, Chen S and Xiao G: Osteoarthritis: Pathogenic signaling pathways and therapeutic targets. Signal Transduct Target Ther. 8(56)2023.PubMed/NCBI View Article : Google Scholar

Taniguchi N, Caramés B, Ronfani L, Ulmer U, Komiya S, Bianchi ME and Lotz M: Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis. Proc Natl Acad Sci USA. 106:1181–1186. 2009.PubMed/NCBI View Article : Google Scholar

Johnson EO, Charchandi A, Babis GC and Soucacos PN: Apoptosis in osteoarthritis: Morphology, mechanisms, and potential means for therapeutic intervention. J Surg Orthop Adv. 17:147–152. 2008.PubMed/NCBI

Kawaguchi H: Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models. Mol Cells. 25:1–6. 2008.PubMed/NCBI

Hashimoto S, Ochs RL, Rosen F, Quach J, McCabe G, Solan J, Seegmiller JE, Terkeltaub R and Lotz M: Chondrocyte-derived apoptotic bodies and calcification of articular cartilage. Proc Natl Acad Sci USA. 95:3094–3099. 1998.PubMed/NCBI View Article : Google Scholar

Liu L, Luo P, Yang M, Wang J, Hou W and Xu P: The role of oxidative stress in the development of knee osteoarthritis: A comprehensive research review. Front Mol Biosci. 9(1001212)2022.PubMed/NCBI View Article : Google Scholar

Ryu JH, Shin Y, Huh YH, Yang S, Chun CH and Chun JS: Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Cell Death Differ. 19:440–450. 2012.PubMed/NCBI View Article : Google Scholar

Chen H, Wang J, Hu B, Wu X, Chen Y, Li R and Yuan W: MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2. Mol Cell Biochem. 406:21–30. 2015.PubMed/NCBI View Article : Google Scholar

Chou CT, Yang JS and Lee MR: Apoptosis in rheumatoid arthritis-expression of Fas, Fas-L, p53, and Bcl-2 in rheumatoid synovial tissues. J Pathol. 193:110–116. 2001.PubMed/NCBI View Article : Google Scholar

Lee MS, Trindade MC, Ikenoue T, Goodman SB, Schurman DJ and Smith RL: Regulation of nitric oxide and bcl-2 expression by shear stress in human osteoarthritic chondrocytes in vitro. J Cell Biochem. 90:80–86. 2003.PubMed/NCBI View Article : Google Scholar

Chen WP, Jin GJ, Xiong Y, Hu PF, Bao JP and Wu LD: Rosmarinic acid down-regulates NO and PGE₂ expression via MAPK pathway in rat chondrocytes. J Cell Mol Med. 22:346–353. 2018.PubMed/NCBI View Article : Google Scholar

Bijlsma JW, Berenbaum F and Lafeber FP: Osteoarthritis: An update with relevance for clinical practice. Lancet. 377:2115–2126. 2011.PubMed/NCBI View Article : Google Scholar

Wu X, Crawford R, Xiao Y, Mao X and Prasadam I: Osteoarthritic subchondral bone release exosomes that promote cartilage degeneration. Cells. 10(251)2021.PubMed/NCBI View Article : Google Scholar

Mansell JP, Collins C and Bailey AJ: Bone, not cartilage, should be the major focus in osteoarthritis. Nat Clin Pract Rheumatol. 3:306–307. 2007.PubMed/NCBI View Article : Google Scholar

Ajami S, Javaheri B, Chang YM, Maruthainar N, Khan T, Donaldson J, Pitsillides AA and Liu C: Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints. Sci Rep. 12(6694)2022.PubMed/NCBI View Article : Google Scholar

de Rooij M, van der Leeden M, Heymans MW, Holla JF, Häkkinen A, Lems WF, Roorda LD, Veenhof C, Sanchez-Ramirez DC, de Vet HC and Dekker J: Prognosis of pain and physical functioning in patients with knee osteoarthritis: A systematic review and meta-analysis. Arthritis Care Res (Hoboken). 68:481–492. 2016.PubMed/NCBI View Article : Google Scholar

Emmert D, Rasche T, Stieber C, Conrad R and Mücke M: Knee pain-symptoms, diagnosis and therapy of osteoarthritis. MMW Fortschr Med. 160:58–64. 2018.PubMed/NCBI View Article : Google Scholar : (In German).

Sinusas K: Osteoarthritis: Diagnosis and treatment. Am Fam Physician. 85:49–56. 2012.PubMed/NCBI

Kolasinski SL, Neogi T, Hochberg MC, Oatis C, Guyatt G, Block J, Callahan L, Copenhaver C, Dodge C, Felson D, et al: 2019 American college of Rheumatology/Arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 72:149–162. 2020.PubMed/NCBI View Article : Google Scholar

Pessler F, Dai L, Diaz-Torne C, Gomez-Vaquero C, Paessler ME, Zheng DH, Einhorn E, Range U, Scanzello C and Schumacher HR: The synovitis of ‘Non-Inflammatory’ orthopaedic arthropathies: A quantitative histological and immunohistochemical analysis. Ann Rheum Dis. 67:1184–1187. 2008.PubMed/NCBI View Article : Google Scholar

Katsuragawa Y, Saitoh K, Tanaka N, Wake M, Ikeda Y, Furukawa H, Tohma S, Sawabe M, Ishiyama M, Yagishita S, et al: Changes of human menisci in osteoarthritic knee joints. Osteoarthritis Cartilage. 18:1133–1143. 2010.PubMed/NCBI View Article : Google Scholar

Krackow KA, Mandeville DS, Rachala SR, Bayers-Thering M and Osternig LR: Torsion deformity and joint loading for medial knee osteoarthritis. Gait Posture. 33:625–629. 2011.PubMed/NCBI View Article : Google Scholar

Incze MA: I have arthritis of the knees: What Should I Do? JAMA Intern Med. 179(736)2019.PubMed/NCBI View Article : Google Scholar

Huang J, Chen X, Xia M, Lv S and Tong P: West Lake staging: A new staging system orchestrated by X-ray and MRI on knee osteoarthritis. J Orthop Surg (Hong Kong). 29(23094990211049587)2021.PubMed/NCBI View Article : Google Scholar

Sukerkar PA and Doyle Z: Imaging of osteoarthritis of the knee. Radiol Clin North Am. 60:605–616. 2022.PubMed/NCBI View Article : Google Scholar

Zarringam D, Saris DBF and Bekkers JEJ: The value of SPECT/CT for knee osteoarthritis: A systematic review. Cartilage. 12:431–437. 2021.PubMed/NCBI View Article : Google Scholar

Bousson V, Lowitz T, Laouisset L, Engelke K and Laredo JD: CT imaging for the investigation of subchondral bone in knee osteoarthritis. Osteoporos Int. 23 (Suppl 8):S861–S865. 2012.PubMed/NCBI View Article : Google Scholar

Watson PJ, Carpenter TA, Hall LD and Tyler JA: Cartilage swelling and loss in a spontaneous model of osteoarthritis visualized by magnetic resonance imaging. Osteoarthritis Cartilage. 4:197–207. 1996.PubMed/NCBI View Article : Google Scholar

Hayashi D, Guermazi A, Kwoh CK, Hannon MJ, Moore C, Jakicic JM, Green SM and Roemer FW: Semiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: A comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences. BMC Musculoskelet Disord. 12(198)2011.PubMed/NCBI View Article : Google Scholar

Blumenkrantz G and Majumdar S: Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis. Eur Cell Mater. 13:76–86. 2007.PubMed/NCBI View Article : Google Scholar

Mosher TJ and Dardzinski BJ: Cartilage MRI T2 relaxation time mapping: Overview and applications. Semin Musculoskelet Radiol. 8:355–368. 2004.PubMed/NCBI View Article : Google Scholar

Nissi MJ, Rieppo J, Töyräs J, Laasanen MS, Kiviranta I, Jurvelin JS and Nieminen MT: T(2) relaxation time mapping reveals age- and species-related diversity of collagen network architecture in articular cartilage. Osteoarthritis Cartilage. 14:1265–1271. 2006.PubMed/NCBI View Article : Google Scholar

Dardzinski BJ, Mosher TJ, Li S, Van Slyke MA and Smith MB: Spatial variation of T2 in human articular cartilage. Radiology. 205:546–550. 1997.PubMed/NCBI View Article : Google Scholar

Liebl H, Joseph G, Nevitt MC, Singh N, Heilmeier U, Subburaj K, Jungmann PM, McCulloch CE, Lynch JA, Lane NE and Link TM: Early T2 changes predict onset of radiographic knee osteoarthritis: Data from the osteoarthritis initiative. Ann Rheum Dis. 74:1353–1359. 2015.PubMed/NCBI View Article : Google Scholar

Conaghan P: Is MRI useful in osteoarthritis? Best Pract Res Clin Rheumatol. 20:57–68. 2006.PubMed/NCBI View Article : Google Scholar

Zhao X, Gong W, Li X, Yang W, Yang D and Liu Z: Back propagation neural network-based ultrasound image for diagnosis of cartilage lesions in knee osteoarthritis. J Healthc Eng. 2021(2584291)2021.PubMed/NCBI View Article : Google Scholar

McCrae F, Shouls J, Dieppe P and Watt I: Scintigraphic assessment of osteoarthritis of the knee joint. Ann Rheum Dis. 51:938–942. 1992.PubMed/NCBI View Article : Google Scholar

Garnero P, Mazières B, Guéguen A, Abbal M, Berdah L, Lequesne M, Nguyen M, Salles JP, Vignon E and Dougados M: Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological joint damage in patients with hip osteoarthritis: The ECHODIAH cohort. J Rheumatol. 32:697–703. 2005.PubMed/NCBI

Schouten JS, Van den Ouweland FA, Valkenburg HA and Lamberts SW: Insulin-like growth factor-1: A prognostic factor of knee osteoarthritis. Br J Rheumatol. 32:274–280. 1993.PubMed/NCBI View Article : Google Scholar

Manicourt DH, Fujimoto N, Obata K and Thonar EJ: Serum levels of collagenase, stromelysin-1, and TIMP-1. Age- and sex-related differences in normal subjects and relationship to the extent of joint involvement and serum levels of antigenic keratan sulfate in patients with osteoarthritis. Arthritis Rheum. 37:1774–1783. 1994.PubMed/NCBI View Article : Google Scholar

Zhang W, Doherty M, Arden N, Bannwarth B, Bijlsma J, Gunther KP, Hauselmann HJ, Herrero-Beaumont G, Jordan K, Kaklamanis P, et al: EULAR evidence based recommendations for the management of hip osteoarthritis: Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 64:669–681. 2005.PubMed/NCBI View Article : Google Scholar

Zeng CY, Zhang ZR, Tang ZM and Hua FZ: Benefits and mechanisms of exercise training for knee osteoarthritis. Front Physiol. 12(794062)2021.PubMed/NCBI View Article : Google Scholar

Wellsandt E and Golightly Y: Exercise in the management of knee and hip osteoarthritis. Curr Opin Rheumatol. 30:151–159. 2018.PubMed/NCBI View Article : Google Scholar

Li Y, Su Y, Chen S, Zhang Y, Zhang Z, Liu C, Lu M, Liu F, Li S, He Z, et al: The effects of resistance exercise in patients with knee osteoarthritis: A systematic review and meta-analysis. Clin Rehabil. 30:947–959. 2016.PubMed/NCBI View Article : Google Scholar

Page CJ, Hinman RS and Bennell KL: Physiotherapy management of knee osteoarthritis. Int J Rheum Dis. 14:145–151. 2011.PubMed/NCBI View Article : Google Scholar

van Doormaal MCM, Meerhoff GA, Vliet Vlieland TPM and Peter WF: A clinical practice guideline for physical therapy in patients with hip or knee osteoarthritis. Musculoskeletal Care. 18:575–595. 2020.PubMed/NCBI View Article : Google Scholar

Peter WF, Jansen MJ, Hurkmans EJ, Bloo H, Dekker J, Dilling RG, Hilberdink W, Kersten-Smit C, de Rooij M, Veenhof C, et al: Physiotherapy in hip and knee osteoarthritis: Development of a practice guideline concerning initial assessment, treatment and evaluation. Acta Reumatol Port. 36:268–281. 2011.PubMed/NCBI

Kloppenburg M, Kroon FP, Blanco FJ, Doherty M, Dziedzic KS, Greibrokk E, Haugen IK, Herrero-Beaumont G, Jonsson H, Kjeken I, et al: 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis. 78:16–24. 2019.PubMed/NCBI View Article : Google Scholar

Rausch Osthoff AK, Niedermann K, Braun J, Adams J, Brodin N, Dagfinrud H, Duruoz T, Esbensen BA, Günther KP, Hurkmans E, et al: 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. Ann Rheum Dis. 77:1251–1260. 2018.PubMed/NCBI View Article : Google Scholar

Kroon FPB, Carmona L, Schoones JW and Kloppenburg M: Efficacy and safety of non-pharmacological, pharmacological and surgical treatment for hand osteoarthritis: A systematic literature review informing the 2018 update of the EULAR recommendations for the management of hand osteoarthritis. RMD Open. 4(e000734)2018.PubMed/NCBI View Article : Google Scholar

Wang HM, Liu JN and Zhao Y: Progress on integrated Chinese and Western medicine in the treatment of osteoarthritis. Chin J Integr Med. 16:378–384. 2010.PubMed/NCBI View Article : Google Scholar

Xu X, Wan Y, Gong L, Ma Z and Xu T: Chinese herbal medicine Yanghe decoction for knee osteoarthritis: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 99(e21877)2020.PubMed/NCBI View Article : Google Scholar

Xia H, Cao D and Yang F, Yang W, Li W, Liu P, Wang S and Yang F: Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt/β-catenin signaling pathway. Biomed Pharmacother. 122(109708)2020.PubMed/NCBI View Article : Google Scholar

Hochberg MC and Dougados M: Pharmacological therapy of osteoarthritis. Best Pract Res Clin Rheumatol. 15:583–593. 2001.PubMed/NCBI View Article : Google Scholar

Nelson AE, Allen KD, Golightly YM, Goode AP and Jordan JM: A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative. Semin Arthritis Rheum. 43:701–712. 2014.PubMed/NCBI View Article : Google Scholar

Bindu S, Mazumder S and Bandyopadhyay U: Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 180(114147)2020.PubMed/NCBI View Article : Google Scholar

Bacchi S, Palumbo P, Sponta A and Coppolino MF: Clinical pharmacology of non-steroidal anti-inflammatory drugs: A review. Antiinflamm Antiallergy Agents Med Chem. 11:52–64. 2012.PubMed/NCBI View Article : Google Scholar

Jones R: Nonsteroidal anti-inflammatory drug prescribing: Past, present, and future. Am J Med. 110 (Suppl):4S–7S. 2001.PubMed/NCBI View Article : Google Scholar

Puljak L, Marin A, Vrdoljak D, Markotic F, Utrobicic A and Tugwell P: Celecoxib for osteoarthritis. Cochrane Database Syst Rev. 5(CD009865)2017.PubMed/NCBI View Article : Google Scholar

Mastbergen SC, Bijlsma JW and Lafeber FP: Selective COX-2 inhibition is favorable to human early and late-stage osteoarthritic cartilage: A human in vitro study. Osteoarthritis Cartilage. 13:519–526. 2005.PubMed/NCBI View Article : Google Scholar

Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, Anderson WF, Zauber A, Hawk E and Bertagnolli M: Adenoma Prevention with Celecoxib (APC) Study Investigators. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med. 352:1071–1080. 2005.PubMed/NCBI View Article : Google Scholar

Elsawy NA, Ibrahiem AH, Younis GA, Meheissen MA and Abdel-Fattah YH: Clinical examination, ultrasound assessment and aspiration of knee effusion in primary knee osteoarthritis patients. J Orthop Surg Res. 18(422)2023.PubMed/NCBI View Article : Google Scholar

Henricsdotter C, Ellegaard K, Klokker L, Bartholdy C, Bandak E, Bartels EM, Bliddal H and Henriksen M: Changes in ultrasound assessed markers of inflammation following intra-articular steroid injection combined with exercise in knee osteoarthritis: Exploratory outcome from a randomized trial. Osteoarthritis Cartilage. 24:814–821. 2016.PubMed/NCBI View Article : Google Scholar

Wang SZ, Guo YD, Zhang XJ and Wang C: Intra-articular injection of compound betamethasone and hyaluronic acid for the treatment of moderate-severe knee osteoarthritis: A randomized controlled trial. Zhongguo Gu Shang. 34:424–428. 2021.PubMed/NCBI View Article : Google Scholar : (In Chinese).

Deyle GD, Allen CS, Allison SC, Gill NW, Hando BR, Petersen EJ, Dusenberry DI and Rhon DI: Physical therapy versus glucocorticoid injection for osteoarthritis of the knee. N Engl J Med. 382:1420–1429. 2020.PubMed/NCBI View Article : Google Scholar

Zhang Y, Ruan G, Zheng P, Huang S, Zhou X, Liu X, Hu W, Feng H, Lin Y, He J, et al: Efficacy and safety of GLucocorticoid injections into InfrapaTellar faT pad in patients with knee ostEoarthRitiS: Protocol for the GLITTERS randomized controlled trial. Trials. 24(6)2023.PubMed/NCBI View Article : Google Scholar

Jin L, Xu K, Liang Y, Du P, Wan S and Jiang C: Effect of hyaluronic acid on cytokines and immune cells change in patients of knee osteoarthritis. BMC Musculoskelet Disord. 23(812)2022.PubMed/NCBI View Article : Google Scholar

Georgiev T and Angelov AK: Modifiable risk factors in knee osteoarthritis: Treatment implications. Rheumatol Int. 39:1145–1157. 2019.PubMed/NCBI View Article : Google Scholar

Liao CD, Chen HC, Huang MH, Liou TH, Lin CL and Huang SW: Comparative efficacy of intra-articular injection, physical therapy, and combined treatments on pain, function, and sarcopenia indices in knee osteoarthritis: A network meta-analysis of randomized controlled trials. Int J Mol Sci. 24(6078)2023.PubMed/NCBI View Article : Google Scholar

Xie X, Zhang C and Tuan RS: Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther. 16(204)2014.PubMed/NCBI View Article : Google Scholar

Duymus TM, Mutlu S, Dernek B, Komur B, Aydogmus S and Kesiktas FN: Choice of intra-articular injection in treatment of knee osteoarthritis: Platelet-rich plasma, hyaluronic acid or ozone options. Knee Surg Sports Traumatol Arthrosc. 25:485–492. 2017.PubMed/NCBI View Article : Google Scholar

Taqi A, Gran S and Knaggs RD: Current use of analgesics and the risk of falls in people with knee osteoarthritis: A population-based cohort study using primary care and hospital records. Osteoarthr Cartil Open. 3(100165)2021.PubMed/NCBI View Article : Google Scholar

Sharma SK, Vij AS and Sharma M: Mechanisms and clinical uses of capsaicin. Eur J Pharmacol. 720:55–62. 2013.PubMed/NCBI View Article : Google Scholar

Liu J and Zang YJ: Comparative study between three analgesic agents for the pain management during extracorporeal shock wave lithotripsy. Urol J. 10:942–945. 2013.PubMed/NCBI

Guo J, Hu X, Wang J, Yu B, Li J, Chen J, Nie X, Zheng Z, Wang S and Qin Q: Safety and efficacy of compound methyl salicylate liniment for topical pain: A multicenter real-world study in China. Front Pharmacol. 13(1015941)2022.PubMed/NCBI View Article : Google Scholar

Riddle DL, Moxley G and Dumenci L: Response to comments in: Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study by Clockaerts et al. Ann Rheum Dis. 72(e12)2013.PubMed/NCBI View Article : Google Scholar

Sondergaard BC, Madsen SH, Segovia-Silvestre T, Paulsen SJ, Christiansen T, Pedersen C, Bay-Jensen AC and Karsdal MA: Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes. BMC Musculoskelet Disord. 11(62)2010.PubMed/NCBI View Article : Google Scholar

Armagan O, Serin DK, Calisir C, Dokumacioglu A, Ozgen M, Oner S and Alatas O: Inhalation therapy of calcitonin relieves osteoarthritis of the knee. J Korean Med Sci. 27:1405–1410. 2012.PubMed/NCBI View Article : Google Scholar

Tanaka H, Ueta Y, Yamashita U, Kannan H and Yamashita H: Biphasic changes in behavioral, endocrine, and sympathetic systems in adjuvant arthritis in Lewis rats. Brain Res Bull. 39:33–37. 1996.PubMed/NCBI View Article : Google Scholar

Sawitzke AD, Shi H, Finco MF, Dunlop DD, Harris CL, Singer NG, Bradley JD, Silver D, Jackson CG, Lane NE, et al: Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis. 69:1459–1464. 2010.PubMed/NCBI View Article : Google Scholar

Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JW, Dieppe P, Gunther K, Hauselmann H, Herrero-Beaumont G, Kaklamanis P, et al: EULAR Recommendations 2003: An evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 62:1145–1155. 2003.PubMed/NCBI View Article : Google Scholar

Bishnoi M, Jain A, Hurkat P and Jain SK: Chondroitin sulphate: A focus on osteoarthritis. Glycoconj J. 33:693–705. 2016.PubMed/NCBI View Article : Google Scholar

Fidelix TS, Macedo CR, Maxwell LJ and Fernandes Moça Trevisani V: Diacerein for osteoarthritis. Cochrane Database Syst Rev: CD005117, 2014.

Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE and Gossett C: Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomised, placebo-controlled clinical trial. Lancet. 357:251–256. 2001.PubMed/NCBI View Article : Google Scholar

Loeser RF, Goldring SR, Scanzello CR and Goldring MB: Osteoarthritis: A disease of the joint as an organ. Arthritis Rheum. 64:1697–1707. 2012.PubMed/NCBI View Article : Google Scholar

Sadowski T and Steinmeyer J: Effects of tetracyclines on the production of matrix metalloproteinases and plasminogen activators as well as of their natural inhibitors, tissue inhibitor of metalloproteinases-1 and plasminogen activator inhibitor-1. Inflamm Res. 50:175–182. 2001.PubMed/NCBI View Article : Google Scholar

Malemud CJ: Inhibition of MMPs and ADAM/ADAMTS. Biochem Pharmacol. 165:33–40. 2019.PubMed/NCBI View Article : Google Scholar

Rosenbaum CC, O'Mathúna DP, Chavez M and Shields K: Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern Ther Health Med. 16:32–40. 2010.PubMed/NCBI

Gui T, Luo L, Chhay B, Zhong L, Wei Y, Yao L, Yu W, Li J, Nelson CL, Tsourkas A, et al: Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy. Biomaterials. 283(121437)2022.PubMed/NCBI View Article : Google Scholar

Mathieu S, Soubrier M, Peirs C, Monfoulet LE, Boirie Y and Tournadre A: A Meta-analysis of the impact of nutritional supplementation on osteoarthritis symptoms. Nutrients. 14(1607)2022.PubMed/NCBI View Article : Google Scholar

Yao H, Xu J, Wang J, Zhang Y, Zheng N, Yue J, Mi J, Zheng L, Dai B, Huang W, et al: Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice. Bioact Mater. 6:1341–1352. 2021.PubMed/NCBI View Article : Google Scholar

Suantawee T, Tantavisut S, Adisakwattana S, Tanavalee A, Yuktanandana P, Anomasiri W, Deepaisarnsakul B and Honsawek S: Oxidative stress, vitamin e, and antioxidant capacity in knee osteoarthritis. J Clin Diagn Res. 7:1855–1859. 2013.PubMed/NCBI View Article : Google Scholar

Bhattacharya I, Saxena R and Gupta V: Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population. Ther Adv Musculoskelet Dis. 4:11–19. 2012.PubMed/NCBI View Article : Google Scholar

Karsdal MA, Tanko LB, Riis BJ, Sondergard BC, Henriksen K, Altman RD, Qvist P and Christiansen C: Calcitonin is involved in cartilage homeostasis: Is calcitonin a treatment for OA? Osteoarthritis Cartilage. 14:617–624. 2006.PubMed/NCBI View Article : Google Scholar

Saberianpour S, Abolbashari S, Modaghegh MHS, Karimian MS, Eid AH, Sathyapalan T and Sahebkar A: Therapeutic effects of statins on osteoarthritis: A review. J Cell Biochem. 123:1285–1297. 2022.PubMed/NCBI View Article : Google Scholar

Cook JL and Payne JT: Surgical treatment of osteoarthritis. Vet Clin North Am Small Anim Pract. 27:931–944. 1997.PubMed/NCBI View Article : Google Scholar

Gomoll AH, Filardo G, de Girolamo L, Espregueira-Mendes J, Marcacci M, Rodkey WG, Steadman JR, Zaffagnini S and Kon E: Surgical treatment for early osteoarthritis. Part I: Cartilage repair procedures. Knee Surg Sports Traumatol Arthrosc. 20:450–466. 2012.PubMed/NCBI View Article : Google Scholar

Krych AJ, Bert JM and Levy BA: Treatment of OA of the knee in the middle-aged athlete: The role of arthroscopy. Sports Med Arthrosc Rev. 21:23–30. 2013.PubMed/NCBI View Article : Google Scholar

Gobbi A, Lane JG and Dallo I: Editorial commentary: Cartilage restoration-what is currently available? Arthroscopy. 36:1625–1628. 2020.PubMed/NCBI View Article : Google Scholar

Yasunaga Y, Fujii J, Tanaka R, Yasuhara S, Yamasaki T, Adachi N and Ochi M: Rotational acetabular osteotomy. Clin Orthop Surg. 9:129–135. 2017.PubMed/NCBI View Article : Google Scholar

Li OL, Pritchett S, Giffin JR and Spouge ARI: High Tibial osteotomy: An update for radiologists. AJR Am J Roentgenol. 218:701–712. 2022.PubMed/NCBI View Article : Google Scholar

Han J, Zeng Z, Pei F and Zheng T: An implementation study of periarticular knee osteotomy in the treatment of knee osteoarthritis. Am J Transl Res. 13:4771–4779. 2021.PubMed/NCBI

Liao CD, Huang SW, Huang YY and Lin CL: Effects of Sarcopenic obesity and its confounders on knee range of motion outcome after total knee replacement in older adults with knee osteoarthritis: A retrospective study. Nutrients. 13(3717)2021.PubMed/NCBI View Article : Google Scholar

Liu CY, Li CD, Wang L, Ren S, Yu FB, Li JG, Ma JX and Ma XL: Function scores of different surgeries in the treatment of knee osteoarthritis: A PRISMA-compliant systematic review and network-meta analysis. Medicine (Baltimore). 97(e10828)2018.PubMed/NCBI View Article : Google Scholar

Xue YY, Shi JN, Zhang K, Zhang HH and Yan SH: The effects of total knee arthroplasty on knee proprioception of patients with knee osteoarthritis: A meta-analysis. J Orthop Surg Res. 17(258)2022.PubMed/NCBI View Article : Google Scholar

He M, Zhong X, Li Z, Shen K and Zeng W: Progress in the treatment of knee osteoarthritis with high Tibial osteotomy: A systematic review. Syst Rev. 10(56)2021.PubMed/NCBI View Article : Google Scholar

Dell'Isola A, Allan R, Smith SL, Marreiros SS and Steultjens M: Identification of clinical phenotypes in knee osteoarthritis: A systematic review of the literature. BMC Musculoskelet Disord. 17(425)2016.PubMed/NCBI View Article : Google Scholar

Lin M, Li X, Liang W, Liu J, Guo J, Zheng J and Liu X: Needle-knife therapy improves the clinical symptoms of knee osteoarthritis by inhibiting the expression of inflammatory cytokines. Exp Ther Med. 7:835–842. 2014.PubMed/NCBI View Article : Google Scholar

Du X, Liu ZY, Tao XX, Mei YL, Zhou DQ, Cheng K, Gao SL, Shi HY, Song C and Zhang XM: Research progress on the pathogenesis of knee osteoarthritis. Orthop Surg: Jul 12, 2023 doi: 10.1111/os.13809 (Epub ahead of print).

Dai W, Cheng J, Yan W, Cao C, Zhao F, Li Q, Hu X, Wang J and Ao Y: Enhanced osteochondral repair with hyaline cartilage formation using an extracellular matrix-inspired natural scaffold. Sci Bull (Beijing): Aug 1, 2023 doi: 10.1016/j.scib.2023.07.050 (Epub ahead of print).

Li C, Liu Y, Weng T, Yang M, Wang X and Chai W: Fabrication of injectable Kartogenin-conjugated composite hydrogel with a sustained drug release for cartilage repair. Pharmaceutics. 15(1949)2023.PubMed/NCBI View Article : Google Scholar

Deng C, Chen Y, Zhao X, Yu L, Xiao Y, Li H, Zhang Y, Ai K, Zhou D, Bai X, et al: Apoptotic neutrophil membrane-camouflaged liposomes for dually targeting synovial macrophages and fibroblasts to attenuate osteoarthritis. ACS Appl Mater Interfaces: Jul 31, 2023 doi: 10.1021/acsami.3c05861 (Epub ahead of print).

Liu R, Liu Z, Chen H, He S, Wang S, Dai J and Li X: Ginkgolide K delays the progression of osteoarthritis by regulating YAP to promote the formation of cartilage extracellular matrix. Phytother Res: Aug 1, 2023 doi: 10.1002/ptr.7953 (Epub ahead of print).

Kuppa SS, Kim HK, Kang JY, Lee SC, Yang HY, Sankaranarayanan J and Seon JK: Polynucleotides suppress inflammation and stimulate matrix synthesis in an in vitro Cell-based osteoarthritis model. Int J Mol Sci. 24(12282)2023.PubMed/NCBI View Article : Google Scholar

Chen S, Meng C, He Y, Xu H, Qu Y, Wang Y, Fan Y, Huang X and You H: An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects. Int Immunopharmacol. 123(110726)2023.PubMed/NCBI View Article : Google Scholar

Wang X, Cai Y, Wu C, Liang J, Tang K, Lin Z, Chen L, Lu Y and Wang Q: Conversion of senescent cartilage into a pro-chondrogenic microenvironment with antibody-functionalized copper sulfate nanoparticles for efficient osteoarthritis therapy. J Nanobiotechnology. 21(258)2023.PubMed/NCBI View Article : Google Scholar