BMP and activin receptor membrane bound inhibitor: BAMBI has multiple roles in gene expression and diseases (Review)
- Authors:
- Xiaochang Chen
- Jue Li
- Aoqi Xiang
- Hua Guan
- Peihong Su
- Lusha Zhang
- Dian Zhang
- Qi Yu
-
Affiliations: Shaanxi Key Laboratory of Ischemic Cardiovascular Diseases, Institute of Basic and Translational Medicine, Xi'an, Shaanxi 710021, P.R. China, Department of Basic Medicine, Xi'an Medical University, Xi'an, Shaanxi 710021, P.R. China, Shaanxi Key Laboratory of Ischemic Cardiovascular Diseases, Institute of Basic and Translational Medicine, Xi'an, Shaanxi 710021, P.R. China - Published online on: November 22, 2023 https://doi.org/10.3892/etm.2023.12316
- Article Number: 28
-
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massagué J and Niehrs C: Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature. 401:480–485. 1999.PubMed/NCBI View Article : Google Scholar | |
Degen WG, Weterman MA, van Groningen JJ, Cornelissen IM, Lemmers JP, Agterbos MA, Geurts van Kessel A, Swart GW and Bloemers HP: Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts. Int J Cancer. 65:460–465. 1996.PubMed/NCBI View Article : Google Scholar | |
Knight C, Simmons D, Gu TT, Gluhak-Heinrich J, Pavlin D, Zeichner-David M and MacDougall M: Cloning, characterization, and tissue expression pattern of mouse Nma/BAMBI during odontogenesis. J Dent Res. 80:1895–1902. 2001.PubMed/NCBI View Article : Google Scholar | |
Chen X, Zhao C, Xu Y, Huang K, Wang Y, Wang X, Zhou X, Pang W, Yang G and Yu T: Adipose-specific BMP and activin membrane-bound inhibitor (BAMBI) deletion promotes adipogenesis by accelerating ROS production. J Biol Chem. 296(100037)2021.PubMed/NCBI View Article : Google Scholar | |
Yao X, Yu T, Xi F, Xu Y, Ma L, Pan X, Chen S, Han M, Yin Y, Dai X, et al: BAMBI shuttling between cytosol and membrane is required for skeletal muscle development and regeneration. Biochem Biophys Res Commun. 509:125–132. 2019.PubMed/NCBI View Article : Google Scholar | |
Zhang Y, Guo Z, Du Z, Yao Z, Guo T, Cheng Y, Wang K, Ma X, Chen C, Kebreab E, et al: Effects of BAMBI on luteinized follicular granulosa cell proliferation and steroid hormone production in sheep. Mol Reprod Dev. 90:153–165. 2023.PubMed/NCBI View Article : Google Scholar | |
Yang Y, Guo C, Liao B, Cao J, Liang C and He X: BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury. Int J Mol Med. 39:423–429. 2017.PubMed/NCBI View Article : Google Scholar | |
Weber F, Treeck O, Mester P and Buechler C: Expression and function of BMP and activin membrane-bound inhibitor (BAMBI) in chronic liver diseases and hepatocellular carcinoma. Int J Mol Sci. 24(3473)2023.PubMed/NCBI View Article : Google Scholar | |
Pawlak JB and Blobe GC: TGF-β superfamily co-receptors in cancer. Dev Dyn. 251:137–163. 2022.PubMed/NCBI View Article : Google Scholar | |
Nickel J, Ten Dijke P and Mueller TD: TGF-β family co-receptor function and signaling. Acta Bioch Bioph Sin (Shanghai). 50:12–36. 2018.PubMed/NCBI View Article : Google Scholar | |
Kirsch T, Sebald W and Dreyer MK: Crystal structure of the BMP-2-BRIA ectodomain complex. Nat Struct Biol. 7:492–496. 2000.PubMed/NCBI View Article : Google Scholar | |
Luo W and Lin SC: Axin: A master scaffold for multiple signaling pathways. Neurosignals. 13:99–113. 2004.PubMed/NCBI View Article : Google Scholar | |
Bai L, Chang HM, Cheng JC, Klausen C, Chu G, Leung PCK and Yang G: SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells. Cell Signal. 37:52–61. 2017.PubMed/NCBI View Article : Google Scholar | |
Guillot N, Kollins D, Gilbert V, Xavier S, Chen J, Gentle M, Reddy A, Bottinger E, Jiang R, Rastaldi MP, et al: BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGFβ signaling. PLoS One. 7(e39406)2012.PubMed/NCBI View Article : Google Scholar | |
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y and Chen YG: Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem. 284:30097–30104. 2009.PubMed/NCBI View Article : Google Scholar | |
Paulsen M, Legewie S, Eils R, Karaulanov E and Niehrs C: Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development. Proc Natl Acad Sci USA. 108:10202–10207. 2011.PubMed/NCBI View Article : Google Scholar | |
Wu Y, Li Q, Zhou X, Yu J, Mu Y, Munker S, Xu C, Shen Z, Müllenbach R, Liu Y, et al: Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer. PLoS One. 7(e35684)2012.PubMed/NCBI View Article : Google Scholar | |
Shehata MM, Sallam AM, Naguib MG and El-Mesallamy HO: Overexpression of BAMBI and SMAD7 impacts prognosis of acute myeloid leukemia patients: A potential TERT non-canonical role. Cancer Biomark. 31:47–58. 2021.PubMed/NCBI View Article : Google Scholar | |
Sekiya T, Oda T, Matsuura K and Akiyama T: Transcriptional regulation of the TGF-beta pseudoreceptor BAMBI by TGF-beta signaling. Biochem Biophys Res Commun. 320:680–684. 2004.PubMed/NCBI View Article : Google Scholar | |
Kashani B, Zandi Z, Pourbagheri-Sigaroodi A, Bashash D and Ghaffari SH: The role of toll-like receptor 4 (TLR4) in cancer progression: A possible therapeutic target? J Cell Physiol. 236:4121–4137. 2021.PubMed/NCBI View Article : Google Scholar | |
Medzhitov R, Preston-Hurlburt P and Janeway CA Jr: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:394–397. 1997.PubMed/NCBI View Article : Google Scholar | |
Federico S, Pozzetti L, Papa A, Carullo G, Gemma S, Butini S, Campiani G and Relitti N: Modulation of the innate immune response by targeting toll-like receptors: A perspective on their agonists and antagonists. J Med Chem. 63:13466–13513. 2020.PubMed/NCBI View Article : Google Scholar | |
Koushki K, Shahbaz SK, Mashayekhi K, Sadeghi M, Zayeri ZD, Taba MY, Banach M, Al-Rasadi K, Johnston TP and Sahebkar A: Anti-inflammatory action of statins in cardiovascular disease: The role of inflammasome and toll-like receptor pathways. Clin Rev Allergy Immunol. 60:175–199. 2021.PubMed/NCBI View Article : Google Scholar | |
Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA and Schwabe RF: TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 13:1324–1332. 2007.PubMed/NCBI View Article : Google Scholar | |
Liu C, Chen X, Yang L, Kisseleva T, Brenner DA and Seki E: Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cells. J Biol Chem. 289:7082–7091. 2014.PubMed/NCBI View Article : Google Scholar | |
Tao L, Xue D, Shen D, Ma W, Zhang J, Wang X, Zhang W, Wu L, Pan K, Yang Y, et al: MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis. Arch Toxicol. 92:2935–2946. 2018.PubMed/NCBI View Article : Google Scholar | |
He Y, Ou Z, Chen X, Zu X, Liu L, Li Y, Cao Z, Chen M, Chen Z, Chen H, et al: LPS/TLR4 signaling enhances TGF-β response through downregulating BAMBI during prostatic hyperplasia. Sci Rep. 6(27051)2016.PubMed/NCBI View Article : Google Scholar | |
Wanninger J, Neumeier M, Bauer S, Weiss TS, Eisinger K, Walter R, Dorn C, Hellerbrand C, Schäffler A and Buechler C: Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes. FEBS Lett. 585:1338–1344. 2011.PubMed/NCBI View Article : Google Scholar | |
Dediulia T: Expression analysis and functional studies of Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor (BAMBI) in hepatocellular carcinoma (unpublished PhD thesis). Ruperto Carola University Heidelberg, Heidelberg, 2019. | |
Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Okada Y, Kurihara C, Irie R, Yokoyama H, et al: Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. Hepatology. 59:154–169. 2014.PubMed/NCBI View Article : Google Scholar | |
Tomita K, Teratani T, Suzuki T, Shimizu M, Sato H, Narimatsu K, Usui S, Furuhashi H, Kimura A, Nishiyama K, et al: Acyl-CoA: Cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells. J Hepatol. 61:98–106. 2014.PubMed/NCBI View Article : Google Scholar | |
Chen M, Liu J, Yang W and Ling W: Lipopolysaccharide mediates hepatic stellate cell activation by regulating autophagy and retinoic acid signaling. Autophagy. 13:1813–1827. 2017.PubMed/NCBI View Article : Google Scholar | |
MacDonald BT, Tamai K and He X: Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell. 17:9–26. 2009.PubMed/NCBI View Article : Google Scholar | |
Perugorria MJ, Olaizola P, Labiano I, Esparza-Baquer A, Marzioni M, Marin JJG, Bujanda L and Banales JM: Wnt-beta-catenin signalling in liver development, health and disease. Nat Rev Gastroenterol Hepatol. 16:121–136. 2019.PubMed/NCBI View Article : Google Scholar | |
Cong F, Schweizer L and Varmus H: Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. Development. 131:5103–5115. 2004.PubMed/NCBI View Article : Google Scholar | |
Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J and He X: A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature. 438:873–877. 2005.PubMed/NCBI View Article : Google Scholar | |
Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A and Niehrs C: Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 438:867–872. 2005.PubMed/NCBI View Article : Google Scholar | |
Schwarz-Romond T, Fiedler M, Shibata N, Butler PJ, Kikuchi A, Higuchi Y and Bienz M: The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization. Nat Struct Mol Biol. 14:484–492. 2007.PubMed/NCBI View Article : Google Scholar | |
Gao C and Chen YG: Dishevelled: The hub of Wnt signaling. Cell Signal. 22:717–727. 2010.PubMed/NCBI View Article : Google Scholar | |
Vlad A, Rohrs S, Klein-Hitpass L and Muller O: The first five years of the Wnt targetome. Cell Signal. 20:795–802. 2008.PubMed/NCBI View Article : Google Scholar | |
Lu HJ, Yan J, Jin PY, Zheng GH, Zhang HL, Bai M, Wu DM, Lu J and Zheng YL: Mechanism of MicroRNA-708 Targeting BAMBI in cell proliferation, migration, and apoptosis in mice with melanoma via the Wnt and TGF-β signaling pathways. Technol Cancer Res Treat. 17(1533034618756784)2018.PubMed/NCBI View Article : Google Scholar | |
Liu K, Song X, Ma H, Liu L, Wen X, Yu J, Wang L and Hu S: Knockdown of BAMBI inhibits β-catenin and transforming growth factor β to suppress metastasis of gastric cancer cells. Mol Med Rep. 10:874–880. 2014.PubMed/NCBI View Article : Google Scholar | |
Yuan H, Liu H, Liu Z, Zhu D, Amos CI, Fang S, Lee JE and Wei Q: Genetic variants in Hippo pathway genes YAP 1, TEAD 1 and TEAD 4 are associated with melanoma-specific survival. Int J Cancer. 137:638–645. 2015.PubMed/NCBI View Article : Google Scholar | |
Zhao HJ, Chang HM, Klausen C, Zhu H, Li Y and Leung PCK: Bone morphogenetic protein 2 induces the activation of WNT/β-catenin signaling and human trophoblast invasion through up-regulating BAMBI. Cell Signal. 67(109489)2020.PubMed/NCBI View Article : Google Scholar | |
Fritzmann J, Morkel M, Besser D, Budczies J, Kosel F, Brembeck FH, Stein U, Fichtner I, Schlag PM and Birchmeier W: A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology. 137:165–175. 2009.PubMed/NCBI View Article : Google Scholar | |
Sekiya T, Adachi S, Kohu K, Yamada T, Higuchi O, Furukawa Y, Nakamura Y, Nakamura T, Tashiro K, Kuhara S, et al: Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J Biol Chem. 279:6840–6846. 2004.PubMed/NCBI View Article : Google Scholar | |
Subramaniam N, Sherman MH, Rao R, Wilson C, Coulter S, Atkins AR, Evans RM, Liddle C and Downes M: Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/beta-catenin signaling. Cancer Prev Res (Phila). 5:553–561. 2012.PubMed/NCBI View Article : Google Scholar | |
Zhou L, Park J, Jang KY, Park HS, Wagle S, Yang KH, Lee KB, Park BH and Kim JR: The overexpression of BAMBI and its involvement in the growth and invasion of human osteosarcoma cells. Oncol Rep. 30:1315–1322. 2013.PubMed/NCBI View Article : Google Scholar | |
Piché ME, Tchernof A and Després JP: Obesity phenotypes, diabetes, and cardiovascular diseases. Circ Res. 126:1477–1500. 2020.PubMed/NCBI View Article : Google Scholar | |
Van Camp JK, De Freitas F, Zegers D, Beckers S, Verhulst SL, Van Hoorenbeeck K, Massa G, Verrijken A, Desager KN, Van Gaal LF and Van Hul W: Investigation of common and rare genetic variation in the BAMBI genomic region in light of human obesity. Endocrine. 52:277–286. 2016.PubMed/NCBI View Article : Google Scholar | |
Luo X, Hutley LJ, Webster JA, Kim YH, Liu DF, Newell FS, Widberg CH, Bachmann A, Turner N, Schmitz-Peiffer C, et al: Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors. Diabetes. 61:124–136. 2012.PubMed/NCBI View Article : Google Scholar | |
Mai Y, Zhang Z, Yang H, Dong P, Chu G, Yang G and Sun S: BMP and activin membrane-bound inhibitor (BAMBI) inhibits the adipogenesis of porcine preadipocytes through Wnt/β-catenin signaling pathway. Biochem Cell Biol. 92:172–182. 2014.PubMed/NCBI View Article : Google Scholar | |
Huang K, Shi X, Wang J, Yao Y, Peng Y, Chen X, Li X and Yang G: Upregulated microRNA-106a promotes porcine preadipocyte proliferation and differentiation by targeting different genes. Genes (Basel). 10(805)2019.PubMed/NCBI View Article : Google Scholar | |
Yang X, Ning Y, Mei C, Zhang W, Sun J, Wang S and Zan L: The role of BAMBI in regulating adipogenesis and myogenesis and the association between its polymorphisms and growth traits in cattle. Mol Biol Rep. 47:5963–5974. 2020.PubMed/NCBI View Article : Google Scholar | |
Polyzos SA, Kountouras J and Mantzoros CS: Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics. Metabolism. 92:82–97. 2019.PubMed/NCBI View Article : Google Scholar | |
Ferguson D and Finck BN: Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus. Nat Rev Endocrinol. 17:484–495. 2021.PubMed/NCBI View Article : Google Scholar | |
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K and Ramnarain D: Non-alcoholic fatty liver disease (NAFLD): A review of pathophysiology, clinical management and effects of weight loss. BMC Endocr Disord. 22(63)2022.PubMed/NCBI View Article : Google Scholar | |
Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J and Bugianesi E: Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 15:11–20. 2018.PubMed/NCBI View Article : Google Scholar | |
Dattaroy D, Seth RK, Sarkar S, Kimono D, Albadrani M, Chandrashekaran V, Hasson FA, Singh UP, Fan D, Nagarkatti M, et al: Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. Eur J Pharmacol. 841:33–48. 2018.PubMed/NCBI View Article : Google Scholar | |
Zhang Q, Shi XE, Song C, Sun S, Yang G and Li X: BAMBI Promotes C2C12 myogenic differentiation by enhancing Wnt/β-Catenin Signaling. Int J Mol Sci. 16:17734–17745. 2015.PubMed/NCBI View Article : Google Scholar | |
Loveland KL, Bakker M, Meehan T, Christy E, von Schönfeldt V, Drummond A and de Kretser D: Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells. Endocrinology. 144:4180–4186. 2003.PubMed/NCBI View Article : Google Scholar | |
Bai L, Chu G, Wang W, Xiang A and Yang G: BAMBI promotes porcine granulosa cell steroidogenesis involving TGF-β signaling. Theriogenology. 100:24–31. 2017.PubMed/NCBI View Article : Google Scholar | |
Bai L, Chu G, Mai Y, Zheng J, Wang W, Zhang Q and Yang G: Identification and expression analyses of BAMBI mediated by FSH in swine luteinizing granulosa cells. Theriogenology. 82:1094–1101. 2014.PubMed/NCBI View Article : Google Scholar | |
Baufeld A and Vanselow J: Increasing cell plating density mimics an early post-LH stage in cultured bovine granulosa cells. Cell Tissue Res. 354:869–880. 2013.PubMed/NCBI View Article : Google Scholar | |
Matsuda F, Inoue N, Manabe N and Ohkura S: Follicular growth and atresia in mammalian ovaries: Regulation by survival and death of granulosa cells. J Reprod Dev. 58:44–50. 2012.PubMed/NCBI View Article : Google Scholar | |
Ouellette Y, Price CA and Carriere PD: Follicular fluid concentration of transforming growth factor-beta1 is negatively correlated with estradiol and follicle size at the early stage of development of the first-wave cohort of bovine ovarian follicles. Domest Anim Endocrinol. 29:623–633. 2005.PubMed/NCBI View Article : Google Scholar | |
Prather RS, Lorson M, Ross JW, Whyte JJ and Walters E: Genetically engineered pig models for human diseases. Annu Rev Anim Biosci. 1:203–219. 2013.PubMed/NCBI View Article : Google Scholar | |
Perleberg C, Kind A and Schnieke A: Genetically engineered pigs as models for human disease. Dis Model Mech. 11(dmm030783)2018.PubMed/NCBI View Article : Google Scholar | |
Lunney JK, Van Goor A, Walker KE, Hailstock T, Franklin J and Dai C: Importance of the pig as a human biomedical model. Sci Transl Med. 13(eabd5758)2021.PubMed/NCBI View Article : Google Scholar | |
Hou N, Du X and Wu S: Advances in pig models of human diseases. Animal Model Exp Med. 5:141–152. 2022.PubMed/NCBI View Article : Google Scholar | |
Du Q, Fu YX, Shu AM, Lv X, Chen YP, Gao YY, Chen J, Wang W, Lv GH, Lu JF and Xu HQ: Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy. Life Sci. 272(118808)2021.PubMed/NCBI View Article : Google Scholar | |
Tesch GH: MCP-1/CCL2: A new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy. Am J Physiol Renal Physiol. 294:F697–F701. 2008.PubMed/NCBI View Article : Google Scholar | |
Liang D, Song Z, Liang W, Li Y and Liu S: Metformin inhibits TGF-beta 1-induced MCP-1 expression through BAMBI-mediated suppression of MEK/ERK1/2 signalling. Nephrology (Carlton). 24:481–488. 2019.PubMed/NCBI View Article : Google Scholar | |
Li J, Gui Y, Ren J, Liu X, Feng Y, Zeng Z, He W, Yang J and Dai C: Metformin protects against cisplatin-induced tubular cell apoptosis and acute kidney injury via AMPKα-regulated autophagy induction. Sci Rep. 6(23975)2016.PubMed/NCBI View Article : Google Scholar | |
Wang D, Chen X and Zhang R: BAMBI promotes macrophage proliferation and differentiation in gliomas. Mol Med Rep. 17:3960–3966. 2018.PubMed/NCBI View Article : Google Scholar | |
Sun SW, Chen L, Zhou M, Wu JH, Meng ZJ, Han HL, Miao SY, Zhu CC and Xiong XZ: BAMBI regulates macrophages inducing the differentiation of Treg through the TGF-β pathway in chronic obstructive pulmonary disease. Respir Res. 20(26)2019.PubMed/NCBI View Article : Google Scholar | |
Pils D, Wittinger M, Petz M, Gugerell A, Gregor W, Alfanz A, Horvat R, Braicu EI, Sehouli J, Zeillinger R, et al: BAMBI is overexpressed in ovarian cancer and co-translocates with Smads into the nucleus upon TGF-beta treatment. Gynecol Oncol. 117:189–197. 2010.PubMed/NCBI View Article : Google Scholar | |
Khin SS, Kitazawa R, Win N, Aye TT, Mori K, Kondo T and Kitazawa S: BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer. Int J Cancer. 125:328–338. 2009.PubMed/NCBI View Article : Google Scholar | |
Sasaki T, Sasahira T, Shimura H, Ikeda S and Kuniyasu H: Effect of Nma on growth inhibition by TGF-betaa in human gastric carcinoma cell lines. Oncol Rep. 11:1219–1223. 2004.PubMed/NCBI | |
Yuan CL, Liang R, Liu ZH, Li YQ, Luo XL, Ye JZ and Lin Y: Bone morphogenetic protein and activin membrane-bound inhibitor overexpression inhibits gastric tumor cell invasion via the transforming growth factor-β/epithelial-mesenchymal transition signaling pathway. Exp Ther Med. 15:5422–5430. 2018.PubMed/NCBI View Article : Google Scholar | |
Wang Z, Zhang Q, Sun Y and Shao F: Long Non-Coding RNA PVT1 Regulates BAMBI to promote tumor progression in non-small cell lung cancer by sponging miR-17-5p. Onco Targets Ther. 13:131–142. 2020.PubMed/NCBI View Article : Google Scholar | |
Grotewold L, Plum M, Dildrop R, Peters T and Rüther U: Bambi is coexpressed with Bmp-4 during mouse embryogenesis. Mech Dev. 100:327–330. 2001.PubMed/NCBI View Article : Google Scholar | |
Chen J, Bush JO, Ovitt CE, Lan Y and Jiang R: The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis. 45:482–486. 2007.PubMed/NCBI View Article : Google Scholar | |
Higashihori N, Song Y and Richman JM: Expression and regulation of the decoy bone morphogenetic protein receptor BAMBI in the developing avian face. Dev Dyn. 237:1500–1508. 2008.PubMed/NCBI View Article : Google Scholar | |
Gonzales CB, Simmons D and MacDougall M: Competing roles of TGFbeta and Nma/BAMBI in odontoblasts. J Dent Res. 89:597–602. 2010.PubMed/NCBI View Article : Google Scholar | |
Xavier S, Gilbert V, Rastaldi MP, Krick S, Kollins D, Reddy A, Bottinger E, Cohen CD and Schlondorff D: BAMBI is expressed in endothelial cells and is regulated by lysosomal/autolysosomal degradation. PLoS One. 5(e12995)2010.PubMed/NCBI View Article : Google Scholar |