Open Access

Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis

  • Authors:
    • Zhou Sun
    • Kejing Zhu
    • Guofu Liang
    • Fu Yan
    • Sheng Chao
    • Lei Jia
    • Yulin Niu
  • View Affiliations

  • Published online on: November 23, 2023     https://doi.org/10.3892/etm.2023.12318
  • Article Number: 30
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The effect of vitamin K on clinical outcomes in patients receiving kidney transplantation is contested according to previous studies. This meta‑analysis aimed to summarize the impact of vitamin K on all‑cause mortality, renal function, inflammation, and vascular/bone health in patients receiving kidney transplantation. EMBASE, PubMed, and Cochrane were searched for literature concerning the effect of vitamin K on clinical outcomes of patients receiving kidney transplantation until December 2022. Normal vitamin K status/vitamin K supplementation was considered as the experimental group; while vitamin K deficiency/no vitamin K supplementation was considered as the control group. All‑cause mortality, renal function indexes, C‑reactive protein (CRP), and vascular/bone health indexes were extracted and analyzed. A total of seven studies with 1,101 patients in the experimental group and 651 patients in the control group were included. All‑cause mortality was decreased in the experimental group vs. the control group [relative risk (95% confidence interval (CI)]: 0.72 (0.60‑0.86), P<0.001]. Regarding renal function indexes, the estimated glomerular filtration rate was increased in the experimental group vs. the control group [mean difference (95% CI): 9.87 (1.48‑18.26), P=0.021]; while creatinine and albumin remained unchanged between the two groups (both P>0.05). Moreover, CRP, systolic blood pressure, diastolic blood pressure, triglycerides, hemoglobin, calcium, and 25‑hydroxyvitamin D were unchanged between the two groups (all P>0.05). Publication bias was low, and the robustness assessed by sensitivity analysis was generally acceptable. Thus vitamin K exerted a potential implication in reducing all‑cause mortality and improving renal function in patients receiving kidney transplantation.
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January-2024
Volume 27 Issue 1

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Spandidos Publications style
Sun Z, Zhu K, Liang G, Yan F, Chao S, Jia L and Niu Y: Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis. Exp Ther Med 27: 30, 2024
APA
Sun, Z., Zhu, K., Liang, G., Yan, F., Chao, S., Jia, L., & Niu, Y. (2024). Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis. Experimental and Therapeutic Medicine, 27, 30. https://doi.org/10.3892/etm.2023.12318
MLA
Sun, Z., Zhu, K., Liang, G., Yan, F., Chao, S., Jia, L., Niu, Y."Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis". Experimental and Therapeutic Medicine 27.1 (2024): 30.
Chicago
Sun, Z., Zhu, K., Liang, G., Yan, F., Chao, S., Jia, L., Niu, Y."Effect of vitamin K on improving post‑kidney transplant outcomes: a meta‑analysis". Experimental and Therapeutic Medicine 27, no. 1 (2024): 30. https://doi.org/10.3892/etm.2023.12318