Open Access

Effect of ubiquitin protease system on DNA damage response in prostate cancer (Review)

  • Authors:
    • Yan Lin
    • Xiaofeng Jin
  • View Affiliations

  • Published online on: November 24, 2023     https://doi.org/10.3892/etm.2023.12321
  • Article Number: 33
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Genomic instability is an essential hallmark of cancer, and cellular DNA damage response (DDR) defects drive tumorigenesis by disrupting genomic stability. Several studies have identified abnormalities in DDR‑associated genes, and a dysfunctional ubiquitin‑proteasome system (UPS) is the most common molecular event in metastatic castration‑resistant prostate cancer (PCa). For example, mutations in Speckle‑type BTB/POZ protein‑Ser119 result in DDR downstream target activation deficiency. Skp2 excessive upregulation inhibits homologous recombination repair and promotes cell growth and migration. Abnormally high expression of a deubiquitination enzyme, ubiquitin‑specific protease 12, stabilizes E3 ligase MDM2, which further leads to p53 degradation, causing DDR interruption and genomic instability. In the present review, the basic pathways of DDR, UPS dysfunction, and its induced DDR alterations mediated by genomic instability, and especially the potential application of UPS and DDR alterations as biomarkers and therapeutic targets in PCa treatment, were described.
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January-2024
Volume 27 Issue 1

Print ISSN: 1792-0981
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Spandidos Publications style
Lin Y and Lin Y: Effect of ubiquitin protease system on DNA damage response in prostate cancer (Review). Exp Ther Med 27: 33, 2024
APA
Lin, Y., & Lin, Y. (2024). Effect of ubiquitin protease system on DNA damage response in prostate cancer (Review). Experimental and Therapeutic Medicine, 27, 33. https://doi.org/10.3892/etm.2023.12321
MLA
Lin, Y., Jin, X."Effect of ubiquitin protease system on DNA damage response in prostate cancer (Review)". Experimental and Therapeutic Medicine 27.1 (2024): 33.
Chicago
Lin, Y., Jin, X."Effect of ubiquitin protease system on DNA damage response in prostate cancer (Review)". Experimental and Therapeutic Medicine 27, no. 1 (2024): 33. https://doi.org/10.3892/etm.2023.12321