Open Access

Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice

  • Authors:
    • Ding-Wen Cheng
    • Yiwen Xu
    • Tao Chen
    • Shu-Qing Zhen
    • Wei Meng
    • Hai-Li Zhu
    • Ling Liu
    • Min Xie
    • Fangshou Zhen
  • View Affiliations

  • Published online on: December 1, 2023     https://doi.org/10.3892/etm.2023.12332
  • Article Number: 44
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Chronic pain reduces the quality of life and ability to function of individuals suffering from it, making it a common public health problem. Neuroinflammation which is mediated by the Nod‑like receptor family pyrin domain‑containing 3 (NLRP3) inflammasome activation in the spinal cord participates and modulates chronic pain. A chronic inflammatory pain mouse model was created in the current study by intraplantar injection of complete Freund's adjuvant (CFA) into C57BL/6J left foot of mice. Following CFA injection, the mice had enhanced pain sensitivities, decreased motor function, increased spinal inflammation and activated spinal astrocytes. Emodin (10 mg/kg) was administered intraperitoneally into the mice for 3 days. As a result, there were fewer spontaneous flinches, higher mechanical threshold values and greater latency to fall. Additionally, in the spinal cord, emodin administration reduced leukocyte infiltration level, downregulated protein level of IL‑1β, lowered histone deacetylase (HDAC)6 and NLRP3 inflammasome activity and suppressed astrocytic activation. Emodin also binds to HDAC6 via four electrovalent bonds. In summary, emodin treatment blocked the HDAC6/NLRP3 inflammasome signaling, suppresses spinal inflammation and alleviates chronic inflammatory pain.
View Figures
View References

Related Articles

Journal Cover

January-2024
Volume 27 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cheng D, Xu Y, Chen T, Zhen S, Meng W, Zhu H, Liu L, Xie M and Zhen F: Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice. Exp Ther Med 27: 44, 2024
APA
Cheng, D., Xu, Y., Chen, T., Zhen, S., Meng, W., Zhu, H. ... Zhen, F. (2024). Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice. Experimental and Therapeutic Medicine, 27, 44. https://doi.org/10.3892/etm.2023.12332
MLA
Cheng, D., Xu, Y., Chen, T., Zhen, S., Meng, W., Zhu, H., Liu, L., Xie, M., Zhen, F."Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice". Experimental and Therapeutic Medicine 27.1 (2024): 44.
Chicago
Cheng, D., Xu, Y., Chen, T., Zhen, S., Meng, W., Zhu, H., Liu, L., Xie, M., Zhen, F."Emodin inhibits HDAC6 mediated NLRP3 signaling and relieves chronic inflammatory pain in mice". Experimental and Therapeutic Medicine 27, no. 1 (2024): 44. https://doi.org/10.3892/etm.2023.12332