Open Access

Predictive values of novel high‑density lipoprotein‑related inflammatory indices in in‑stent restenosis among patients undergoing elective percutaneous coronary intervention

  • Authors:
    • Xuantong Guo
    • Ruihuan Shen
    • Peipei Lu
    • Lihong Ma
  • View Affiliations

  • Published online on: December 13, 2023     https://doi.org/10.3892/etm.2023.12350
  • Article Number: 62
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Inflammation and disorders in lipid metabolism play pivotal roles in the development and progression of in‑stent restenosis (ISR). The present study aimed to investigate the association between the high‑density lipoprotein (HDL)‑related inflammatory indices and the risk of developing ISR among patients undergoing elective percutaneous coronary intervention (PCI). A sum of 1,471 patients undergoing elective PCI were retrospectively included and classified by tertiles of HDL‑related inflammatory indices. The study endpoint was ISR. The multivariable Cox proportional hazards regression analysis with restricted cubic splines (RCS) was used to assess the associations. During a median follow‑up of 62.27 months, 251 (17.06%) patients experienced ISR. The incidence of ISR increased with the increasing white blood cell‑to‑HDL ratio (WHR) tertiles (log‑rank test, overall P=0.0082). After full adjustment, the highest tertile of WHR was significantly associated with a 1.603‑fold risk of ISR (hazard ratio, 1.603; 95% confidence interval, 1.152‑2.231; P=0.005) in contrast to the lowest tertile of the WHR. Results of RCS further indicated that the association between WHR and ISR was in a non‑linear and dose‑dependent manner (non‑linear P=0.034; P overall=0.019). The lymphocyte‑to‑HDL ratio (LHR) and neutrophil‑to‑HDL ratio (NHR) were also significantly and positively associated with the risk of ISR, of which the third tertiles were at increased risk of 41.2 and 44.7% after full adjustment, respectively. Overall, lipid metabolism disorders and inflammation were interconnected in the development of ISR; therefore, HDL‑related inflammatory indices, including WHR, LHR and NHR, might be potential predictors in the prognosis of elective PCI.
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February-2024
Volume 27 Issue 2

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Spandidos Publications style
Guo X, Shen R, Lu P and Ma L: Predictive values of novel high‑density lipoprotein‑related inflammatory indices in in‑stent restenosis among patients undergoing elective percutaneous coronary intervention. Exp Ther Med 27: 62, 2024
APA
Guo, X., Shen, R., Lu, P., & Ma, L. (2024). Predictive values of novel high‑density lipoprotein‑related inflammatory indices in in‑stent restenosis among patients undergoing elective percutaneous coronary intervention. Experimental and Therapeutic Medicine, 27, 62. https://doi.org/10.3892/etm.2023.12350
MLA
Guo, X., Shen, R., Lu, P., Ma, L."Predictive values of novel high‑density lipoprotein‑related inflammatory indices in in‑stent restenosis among patients undergoing elective percutaneous coronary intervention". Experimental and Therapeutic Medicine 27.2 (2024): 62.
Chicago
Guo, X., Shen, R., Lu, P., Ma, L."Predictive values of novel high‑density lipoprotein‑related inflammatory indices in in‑stent restenosis among patients undergoing elective percutaneous coronary intervention". Experimental and Therapeutic Medicine 27, no. 2 (2024): 62. https://doi.org/10.3892/etm.2023.12350