Open Access

Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1

  • Authors:
    • Fei He
    • Chunmian Chen
    • Yangyang Wang
    • Shuen Wang
    • Shuangyan Lyu
    • Junqiang Jiao
    • Guoyong Huang
    • Jiangshun Yang
  • View Affiliations

  • Published online on: December 19, 2023     https://doi.org/10.3892/etm.2023.12358
  • Article Number: 71
  • Copyright : © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

Safranal is an active ingredient of saffron (Crocus sativus L.). Its neuroprotective role in ischemic stroke (IS) through reducing oxidative stress damage has been widely reported. However, the neurorestorative mechanisms of safranal are still in the preliminary stage of exploration. the present study is aimed to discuss the effects of safranal on the recovery of neural function after IS. A middle cerebral artery occlusion/reperfusion (MCAO/R) rat model and an oxygen‑glucose deprivation/reoxygenation (OGD/R) model in rat brain microvascular endothelial cells (RBMEC) were established to explore the effects of safranal on IS in vivo and in vitro. It was found that safranal dramatically reduced infarct size and Nissl's body loss in rats subjected to MCAO/R. Safranal also promoted neuron survival, stimulated neurogenesis, induced angiogenesis and increased SIRT1 expression in vivo and in vitro. Silencing of SIRT1 reversed the above effects of safranal on OGD/R‑induced RBMEC. The present study indicated that safranal was a promising compound to exert neurorestorative effect in IS via upregulating SIRT1 expression. These results offer insight into developing new mechanisms in the recovery of neural function after safranal treatment of IS.
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February-2024
Volume 27 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
He F, Chen C, Wang Y, Wang S, Lyu S, Jiao J, Huang G and Yang J: Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1. Exp Ther Med 27: 71, 2024
APA
He, F., Chen, C., Wang, Y., Wang, S., Lyu, S., Jiao, J. ... Yang, J. (2024). Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1. Experimental and Therapeutic Medicine, 27, 71. https://doi.org/10.3892/etm.2023.12358
MLA
He, F., Chen, C., Wang, Y., Wang, S., Lyu, S., Jiao, J., Huang, G., Yang, J."Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1". Experimental and Therapeutic Medicine 27.2 (2024): 71.
Chicago
He, F., Chen, C., Wang, Y., Wang, S., Lyu, S., Jiao, J., Huang, G., Yang, J."Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1". Experimental and Therapeutic Medicine 27, no. 2 (2024): 71. https://doi.org/10.3892/etm.2023.12358