Open Access

Role of STAT3 in cancer cell epithelial‑mesenchymal transition (Review)

  • Authors:
    • Guoan Zhang
    • Sen Hou
    • Shuyue Li
    • Yequan Wang
    • Wen Cui
  • View Affiliations

  • Published online on: March 13, 2024     https://doi.org/10.3892/ijo.2024.5636
  • Article Number: 48
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Since its discovery, the role of the transcription factor, signal transducer and activator of transcription 3 (STAT3), in both normal physiology and the pathology of numerous diseases, including cancer, has been extensively studied. STAT3 is aberrantly activated in different types of cancer, fulfilling a critical role in cancer progression. The biological process, epithelial‑mesenchymal transition (EMT), is indispensable for embryonic morphogenesis. During the development of cancer, EMT is hijacked to confer motility, tumor cell stemness, drug resistance and adaptation to changes in the microenvironment. The aim of the present review was to outline recent advances in knowledge of the role of STAT3 in EMT, which may contribute to the understanding of the function of STAT3 in EMT in various types of cancer. Delineating the underlying mechanisms associated with the STAT3‑EMT signaling axis may generate novel diagnostic and therapeutic options for cancer treatment.
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May-2024
Volume 64 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang G, Hou S, Li S, Wang Y and Cui W: Role of STAT3 in cancer cell epithelial‑mesenchymal transition (Review). Int J Oncol 64: 48, 2024
APA
Zhang, G., Hou, S., Li, S., Wang, Y., & Cui, W. (2024). Role of STAT3 in cancer cell epithelial‑mesenchymal transition (Review). International Journal of Oncology, 64, 48. https://doi.org/10.3892/ijo.2024.5636
MLA
Zhang, G., Hou, S., Li, S., Wang, Y., Cui, W."Role of STAT3 in cancer cell epithelial‑mesenchymal transition (Review)". International Journal of Oncology 64.5 (2024): 48.
Chicago
Zhang, G., Hou, S., Li, S., Wang, Y., Cui, W."Role of STAT3 in cancer cell epithelial‑mesenchymal transition (Review)". International Journal of Oncology 64, no. 5 (2024): 48. https://doi.org/10.3892/ijo.2024.5636