Open Access

Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)

  • Authors:
    • Ziqiang Wang
    • Yu Zhang
    • Kun Li
  • View Affiliations

  • Published online on: April 9, 2024     https://doi.org/10.3892/ijo.2024.5644
  • Article Number: 56
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

MicroRNAs (miRNAs) are noncoding small nucleic acids that contain ~22 nucleotides and are considered to promote the degradation or inhibit the translation of mRNA by targeting its 3'‑untranslated region. However, growing evidence has revealed that nuclear miRNAs, combined with gene promoters or enhancers, are able to directly mediate gene transcription. These miRNAs exert a critical influence on cancer progression by affecting cell growth, migration and invasion. In this review, the direct regulation of gene expression by nuclear miRNAs at the transcriptional level was discussed and summarized, and their mechanisms of action in cancers were highlighted with reference to the various body systems.
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May-2024
Volume 64 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Z, Zhang Y and Li K: Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review). Int J Oncol 64: 56, 2024
APA
Wang, Z., Zhang, Y., & Li, K. (2024). Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review). International Journal of Oncology, 64, 56. https://doi.org/10.3892/ijo.2024.5644
MLA
Wang, Z., Zhang, Y., Li, K."Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)". International Journal of Oncology 64.5 (2024): 56.
Chicago
Wang, Z., Zhang, Y., Li, K."Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)". International Journal of Oncology 64, no. 5 (2024): 56. https://doi.org/10.3892/ijo.2024.5644