Study of the effectiveness of first‑line treatment in renal cell carcinoma

  • Authors:
    • Alejandro J. Sastre‑Heres
    • Miguel Alaguero Calero
    • Daniel Ruiz‑Sánchez
    • María Teresa Iglesias García
    • Miguel Angel Calleja Hernandez
    • Fernando Martínez Martínez
    • Jaime Peña‑Díaz
  • View Affiliations

  • Published online on: July 18, 2014     https://doi.org/10.3892/mco.2014.353
  • Pages: 1167-1171
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Abstract

The emergence of novel drugs corresponds with the determination of the effectiveness of the current treatments used in clinical practice. A retrospective observational study was conducted to evaluate the effectiveness of first‑line treatments and to test the influence of the prognostic factors established using the Memorial Sloan‑Kettering Cancer Center (MSKCC) and the analysis of Mekhail's study for two or more metastatic sites. The primary endpoints were median progression‑free survival (mPFS) and median overall survival (mOS) times. A total of 65 patients were enrolled and the mPFS and mOS of the patients treated with sunitinib (n=51) were 9.0 and 20.1 months, respectively, and for the patients treated with temsirolimus (n=14) these were 3.0 and 6.2 months, respectively. In the poor‑prognosis (PP) group, a difference of 1.2 months (P=0.049) was found in mPFS depending on the first‑line treatment. A difference of 4.1 months (P=0.023) was also found in mPFS when classified by histology (clear verses non‑clear cell) in the sunitinib‑treatment group. When stratified by the prognostic group, differences of >7 months (P<0.001) were found between the groups. Therefore, it was concluded that the effectiveness of the treatments was reduced compared to previous studies and differences were found in the PP group when classified by first‑line drug and histology. Additionally, the influence of prognostic factors on OS and the value of stratifying patients using these factors have been confirmed.
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November-December 2014
Volume 2 Issue 6

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Sastre‑Heres AJ, Alaguero Calero M, Ruiz‑Sánchez D, Iglesias García MT, Calleja Hernandez MA, Martínez Martínez F and Peña‑Díaz J: Study of the effectiveness of first‑line treatment in renal cell carcinoma. Mol Clin Oncol 2: 1167-1171, 2014
APA
Sastre‑Heres, A.J., Alaguero Calero, M., Ruiz‑Sánchez, D., Iglesias García, M.T., Calleja Hernandez, M.A., Martínez Martínez, F., & Peña‑Díaz, J. (2014). Study of the effectiveness of first‑line treatment in renal cell carcinoma. Molecular and Clinical Oncology, 2, 1167-1171. https://doi.org/10.3892/mco.2014.353
MLA
Sastre‑Heres, A. J., Alaguero Calero, M., Ruiz‑Sánchez, D., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martínez, F., Peña‑Díaz, J."Study of the effectiveness of first‑line treatment in renal cell carcinoma". Molecular and Clinical Oncology 2.6 (2014): 1167-1171.
Chicago
Sastre‑Heres, A. J., Alaguero Calero, M., Ruiz‑Sánchez, D., Iglesias García, M. T., Calleja Hernandez, M. A., Martínez Martínez, F., Peña‑Díaz, J."Study of the effectiveness of first‑line treatment in renal cell carcinoma". Molecular and Clinical Oncology 2, no. 6 (2014): 1167-1171. https://doi.org/10.3892/mco.2014.353