Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors

Huo,Lei; Wang,Xia; Allen,Pamela  K.; Wang,Longyun; Liao,Yuping; Han,Zaide; Shen,Liangfang; Tu,Qingsong; Zhong,Meizuo; Zhuang,Yan; Li,Jing; Hong,Jidong

doi:10.3892/mco.2014.461

Predictors of long-term survival following postoperative radiochemotherapy for pathologically confirmed suprasellar germ cell tumors

Authors:
- Lei Huo
- Xia Wang
- Pamela K. Allen
- Longyun Wang
- Yuping Liao
- Zaide Han
- Liangfang Shen
- Qingsong Tu
- Meizuo Zhong
- Yan Zhuang
- Jing Li
- Jidong Hong
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Affiliations: Department of Neurosurgery, Xiangya Hospital, Central South University, Institute of Skull Base Surgery and Neurooncology, Changsha, Hunan 410008, P.R. China, Department of Radiation Oncology, Xiangya Hospital, Central South University, Institute of Skull Base Surgery and Neurooncology, Changsha, Hunan 410008, P.R. China, Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA, Department of Radiology, Xiangya Hospital, Central South University, Institute of Skull Base Surgery and Neurooncology, Changsha, Hunan 410008, P.R. China
Published online on: November 20, 2014 https://doi.org/10.3892/mco.2014.461
Pages: 430-434

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Abstract

The aim of this study was to evaluate the predictors of long‑term survival following postoperative therapy for suprasellar germ cell tumors (GCTs). A total of 23 patients with pathologically confirmed suprasellar GCTs were reviewed between April, 1987 and October, 2008. The predictors were identified with a univariate Cox proportional hazards model and the results were used to group patients according to outcome. The overall survival (OS) and progression‑free survival (PFS) rates for the good- and poor‑prognosis two groups were estimated with Kaplan‑Meier analysis, with log‑rank tests used to assess differences between the groups. The OS rate for all patients was 82.6% at 5 and 72.9% at 10 years. Lesion size (2‑4 vs. >4 cm) and pathological type (pure germinoma vs. mixed GCT) were the only significant predictors of OS (P<0.05). The OS rate for the good‑prognosis group was 92.9% at both 5 and 10 years, whereas the corresponding rates for the poor‑prognosis group were 66.7 and 40.0%, respectively (P=0.020). The PFS rate for the good‑prognosis group was 92.9% at 5 and 85.7% at 10 years, whereas the corresponding PFS rates for the poor‑prognosis group were 44.4 and 33.3%, respectively (P=0.007). Lesion size and histology predicted outcome following postoperative therapy for suprasellar GCT. Therefore, pathological diagnosis is recommended whenever possible, as histology may dictate the choice of treatment.

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